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Ubiquitous transcription factor required for a diverse set of processes. Additionally we are shipping CNOT8 Antibodies (82) and CNOT8 Kits (7) and many more products for this protein.
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Pharmacological inhibition of FGF signaling or a mutation in the fgf3 (show FGF3 Proteins) gene can compensate the gain of caudal hypothalamic dopaminergic neurons in cnot8m1061 mutants, indicating a role for Fgf3 (show FGF3 Proteins) in control of development of this dopaminergic population
These results indicate that Caf1 (show CHAF1B Proteins) and Ccr4 (show CCR4 Proteins) cooperate in mRNA deadenylation and suggest that the enzyme activities of Caf1 (show CHAF1B Proteins) and Ccr4 (show CCR4 Proteins) are regulated via allosteric interactions within the nuclease (show DCLRE1C Proteins) module.
CNOT7 (show CNOT7 Proteins)/hCAF1 is involved in ICAM-1 (show ICAM1 Proteins) and IL-8 (show IL8 Proteins) regulation by TTP (show ADAMTS13 Proteins) in HPMEC.
show that SMG7 binds directly to POP2, a catalytic subunit of the CCR4 (show CCR4 Proteins)-NOT deadenylase complex, and elicits deadenylation-dependent decapping and 5'-to-3' decay of NMD targets
The anti-proliferative activity of BTG/TOB (show TDO2 Proteins) proteins is mediated via the Caf1a (show CHAF1B Proteins) (CNOT7 (show CNOT7 Proteins)) and Caf1b (show CHAF1A Proteins) (CNOT8) deadenylase subunits of the Ccr4 (show CCR4 Proteins)-not complex.
The NOT1 MIF4G domain binds CAF1 through a pre-formed interface and leaves the CAF1 catalytic site fully accessible to RNA substrates.
N-terminus played a role in modulating hCaf1 activity, stability and aggregation
Together, these results indicate that Tob (show TDO2 Proteins) mediates the recruitment of Caf1 (show CHAF1B Proteins) to the target of CPEB3 (show CPEB3 Proteins) and elicits deadenylation and decay of the mRNA.
MK2 (show KCNA2 Proteins) phosphorylation reduces the ability of TTP (show ADAMTS13 Proteins) to promote deadenylation by inhibiting the recruitment of CAF1 (show CHAF1B Proteins) deadenylase in a mechanism that does not involve sequestration of TTP (show ADAMTS13 Proteins) by 14-3-3 (show YWHAQ Proteins).
Tob (show TDO2 Proteins) interactions with Caf1 (show CHAF1B Proteins) and a C-terminal domain of PABPC1 (show PABPC1 Proteins)
CCR4 (show CCR4 Proteins)-NOT is the deadenylase that removes poly(A) from messages destabilized by miRNAs in human cells.
Ubiquitous transcription factor required for a diverse set of processes. The CCR4-NOT complex functions as general transcription regulation complex (By similarity).
CCR4-NOT transcription complex subunit 8
, CCR4-NOT transcription complex, subunit 8
, ccr4-not transcription complex subunit 8
, CAF1-like protein
, CCR4-associated factor 8
, PGK promoter directed over production