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Plays a role in the deadenylation of mRNAs in the cytoplasm. Additionally we are shipping CNOT6L Antibodies (12) and CNOT6L Proteins (3) and many more products for this protein.
Structural analysis shows that all inhibitors occupy the substrate and magnesium-binding sites of CNOT6L, suggesting that inhibitors compete with both substrate and divalent magnesium ions for overlapping binding sites.
Data show that CNOT6L protein-interleukin 8 (IL-8 (show IL8 ELISA Kits)) is a signaling axis in myogenesis.
Cnot6L, a validated target of miR (show MLXIP ELISA Kits)-146a, affects the stability of Zeb1 (show ZEB1 ELISA Kits) mRNA.
Results identified CNOT6 (show CNOT6 ELISA Kits)/CNOT6L as a key regulator of insulin-like growth factor-binding protein 5 (show IGFBP5 ELISA Kits), which mediates cell cycle arrest and senescence via a p53 (show TP53 ELISA Kits)-dependent pathway.
show that the nuclease (show DCLRE1C ELISA Kits) domain of CNOT6L exhibits full Mg(2 (show MUC7 ELISA Kits)+)-dependent deadenylase activity with strict poly(A) RNA substrate specificity.
CCR4b may be involved in various cellular events that include cell proliferation.
Plays a role in the deadenylation of mRNAs in the cytoplasm. Has 3'-5' poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. May be involved in the deadenylation-dependent degradation of mRNAs through the 3'-UTR AU-rich element-mediated mechanism. Involved in deadenylation- dependent degradation of CDKN1B mRNA (By similarity).
CCR4-NOT transcription complex subunit 6-like
, carbon catabolite repressor protein 4 homolog B