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Ubiquitous transcription factor required for a diverse set of processes. Additionally we are shipping CNOT8 Proteins (5) and many more products for this protein.
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Pharmacological inhibition of FGF signaling or a mutation in the fgf3 (show FGF3 Antibodies) gene can compensate the gain of caudal (show CAD Antibodies) hypothalamic dopaminergic neurons in cnot8m1061 mutants, indicating a role for Fgf3 (show FGF3 Antibodies) in control of development of this dopaminergic population
These results indicate that Caf1 (show CHAF1B Antibodies) and Ccr4 (show CCR4 Antibodies) cooperate in mRNA deadenylation and suggest that the enzyme activities of Caf1 (show CHAF1B Antibodies) and Ccr4 (show CCR4 Antibodies) are regulated via allosteric interactions within the nuclease (show DCLRE1C Antibodies) module.
CNOT7 (show CNOT7 Antibodies)/hCAF1 is involved in ICAM-1 (show ICAM1 Antibodies) and IL-8 (show IL8 Antibodies) regulation by TTP (show ADAMTS13 Antibodies) in HPMEC.
show that SMG7 binds directly to POP2, a catalytic subunit of the CCR4 (show CCR4 Antibodies)-NOT deadenylase complex, and elicits deadenylation-dependent decapping and 5'-to-3' decay of NMD targets
The anti-proliferative activity of BTG/TOB (show TDO2 Antibodies) proteins is mediated via the Caf1a (show CHAF1B Antibodies) (CNOT7 (show CNOT7 Antibodies)) and Caf1b (show CHAF1A Antibodies) (CNOT8) deadenylase subunits of the Ccr4 (show CCR4 Antibodies)-not complex.
The NOT1 MIF4G domain binds CAF1 through a pre-formed interface and leaves the CAF1 catalytic site fully accessible to RNA substrates.
N-terminus played a role in modulating hCaf1 activity, stability and aggregation
Together, these results indicate that Tob (show TDO2 Antibodies) mediates the recruitment of Caf1 (show CHAF1B Antibodies) to the target of CPEB3 (show CPEB3 Antibodies) and elicits deadenylation and decay of the mRNA.
MK2 (show KCNA2 Antibodies) phosphorylation reduces the ability of TTP (show ADAMTS13 Antibodies) to promote deadenylation by inhibiting the recruitment of CAF1 (show CHAF1B Antibodies) deadenylase in a mechanism that does not involve sequestration of TTP (show ADAMTS13 Antibodies) by 14-3-3 (show YWHAQ Antibodies).
Tob (show TDO2 Antibodies) interactions with Caf1 (show CHAF1B Antibodies) and a C-terminal domain of PABPC1 (show PABPC1 Antibodies)
CCR4 (show CCR4 Antibodies)-NOT is the deadenylase that removes poly(A) from messages destabilized by miRNAs in human cells.
study reports that a complex of BTG4 and CAF1 safeguards metaphase II arrest in mammalian eggs by deadenylating maternal mRNAs
Ubiquitous transcription factor required for a diverse set of processes. The CCR4-NOT complex functions as general transcription regulation complex (By similarity).
CCR4-NOT transcription complex subunit 8
, CCR4-NOT transcription complex, subunit 8
, ccr4-not transcription complex subunit 8
, CAF1-like protein
, CCR4-associated factor 8
, PGK promoter directed over production