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Plays a role as inhibitor of T-cells proliferation induced by CD3. Additionally we are shipping CD101 Antibodies (94) and many more products for this protein.
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CD101 inhibits the expansion of colitogenic T cells.
Further support is provided for the hypothesis that Cd101 is insulin (show INS Proteins)-dependent diabetes susceptibility region 10 (Idd10); haplotype and expression analyses of novel Idd10 congenic strains are coupled to the development of a CD101 knockout mouse.
of the eight genes found in the Idd10 region, the CD101 gene was selected as a candidate for Idd10 based on its function in humans and its polymorphism in the NOD strain of mice
Cd101, but not Fcgr1 (show FCGR1A Proteins), is responsible for the Idd10 effect
In patients with intestinal bowel disease, a reduced CD101 expression on peripheral and intestinal monocytes and CD4 (show CD4 Proteins)-positive Tcells correlated with enhanced IL-17 (show IL17A Proteins) production and disease activity.
Low expression of CD39 (show ENTPD1 Proteins)(+) /CD45RA(+) on regulatory T cells (Treg ) cells in type 1 diabetic children in contrast to high expression of CD101(+) /CD129 (show IL9R Proteins)(+) on Treg cells in children with coeliac disease.
Single Nucleotide Polymorphism in CD101 gene may be associated with pancreatic cancer.
Results suggest a possible role for CD101 expression and function in the control of certain manifestations of rheumatoid arthritis pathology.
Plays a role as inhibitor of T-cells proliferation induced by CD3. Inhibits expression of IL2RA on activated T-cells and secretion of IL2. Inhibits tyrosine kinases that are required for IL2 production and cellular proliferation. Inhibits phospholipase C-gamma-1/PLCG1 phosphorylation and subsequent CD3- induced changes in intracellular free calcium. Prevents nuclear translocation of nuclear factor of activated T-cell to the nucleus. Plays a role in the inhibition of T-cell proliferation via IL10 secretion by cutaneous dendritic cells (By similarity).
, immunoglobulin superfamily, member 2
, immunoglobulin superfamily member 2-like
, EWI immunoglobulin subfamily member EWI-101
, glu-Trp-Ile EWI motif-containing protein 101
, immunoglobulin superfamily member 2
, leukocyte surface protein
, cell surface glycoprotein V7