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CD109 encodes a member of the alpha2-macroglobulin/complement superfamily. Additionally we are shipping CD109 Kits (15) and CD109 Proteins (5) and many more products for this protein.
Showing 10 out of 86 products:
Human Polyclonal CD109 Primary Antibody for EIA, WB - ABIN951153
Nie, Zhou, Fu, Wang, Ma: The allele frequencies of HPA 1-16 determined by PCR-SSP in Chinese Cantonese donors. in Transfusion medicine (Oxford, England) 2010
Show all 4 references for ABIN951153
Human Monoclonal CD109 Primary Antibody for BR, FACS - ABIN2662945
Solomon, Sharma, Chan, Morrison, Finberg: CD109 represents a novel branch of the alpha2-macroglobulin/complement gene family. in Gene 2004
Show all 3 references for ABIN2662945
GP96 (show HSP90B1 Antibodies) serves as an essential chaperone for the cell-surface protein (show CD28 Antibodies) glycoprotein A repetitions predominant (GARP (show LRRC32 Antibodies)), which is a docking receptor for latent membrane-associated TGF-beta (show TGFB1 Antibodies) (mLTGF-beta).
CD109 decreases extracellular matrix production and fibrotic responses during hypoxic wound healing
CD109 is present in serum as a soluble form, and suggest its potential as a novel tumor marker in patients with cancers that express CD109.
CD109 might be an important regulator of osteoclastogenesis.
findings demonstrate that CD109 overexpression in the epidermis reduces inflammation and granulation tissue area and improves collagen organization in vivo.
Induction of both Th17-producing cells and Tregs is caused preferentially by Tregs expressing the latent TGF-beta1 (show TGFB1 Antibodies)/GARP (show LRRC32 Antibodies) complex on their cell surface rather than by secreted latent TGF-beta1 (show TGFB1 Antibodies).
CD109 overexpression ameliorates skin fibrosis in a mouse model of bleomycin-induced scleroderma.
CD109 regulates differentiation of keratinocytes via a signaling pathway involving Stat3 (show STAT3 Antibodies).
Expression levels of CD109 was reduced significantly in psoriasis. Lower expression of CD109 and TGF-beta (show TGFB1 Antibodies) RI was highly correlated with higher expression of Smad7 (show SMAD7 Antibodies) and Ki67 (show MKI67 Antibodies), suggesting that CD109 may induce the pathogenesis of psoriasis through Smad7 (show SMAD7 Antibodies)-mediated degradation of TGF-beta (show TGFB1 Antibodies) RI.
sCD109 can bind TGF-beta (show TGFB1 Antibodies), inhibit TGF-beta (show TGFB1 Antibodies) binding to its receptors and decrease TGF-beta (show TGFB1 Antibodies) signalling and TGF-beta (show TGFB1 Antibodies)-induced cellular responses.
These findings indicate that CD109 is an exosomal protein and that the C-terminal region of CD109 is required for its presence in the exosome.
CD109 may be a potential pathology marker for gallbladder squamous cell/adenosquamous carcinomas.
CD109 is specifically expressed in endothelial cells of cutaneous cavernous haemangioma.
The results suggest that circulating endothelial cells express CD109 and represent a rare population of circulating tumor endothelial cells, that play a potentially useful prognostic role in patients with glioblastoma.
CD109 overexpression was significantly associated with surgical stage, distant metastasis, and poor prognosis in myxofibrosarcoma.
Three glioblastoma cell lines, SK-MG-1, U251MG and MG178, were tested and CD109 overexpression attenuated TGF-beta1 (show TGFB1 Antibodies) signaling and enhanced EGF (show EGF Antibodies) signaling in SK-MG-1, but not in U251MG or MG178.
CD109 is highly expressed in TNBC and is a potential biomarker for the initiation, progression, and differentiation of breast cancer tumors.
CD109 plays a critical role in non-small-cell lung cancer (NSCLC) progression, and is overexpressed in advanced NSCLC
This gene encodes a member of the alpha2-macroglobulin/complement superfamily. The encoded GPI-linked glycoprotein is found on the cell surface of platelets, activated T-cells, and endothelial cells. The protein binds to and negatively regulates signaling of transforming growth factor beta (TGF-beta). Multiple transcript variants encoding different isoforms have been found for this gene.
, CD109 antigen-like
, GPI-anchored alpha 2 macroglobulin-related protein
, GPI-anchored alpha-2 macroglobulin-related protein
, Gov platelet alloantigens
, 150 kDa TGF-beta-1-binding protein
, C3 and PZP-like alpha-2-macroglobulin domain-containing protein 7
, CD109 antigen
, activated T-cell marker CD109
, platelet-specific Gov antigen