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CD209 Molecule Proteins (CD209)

CD209 encodes a transmembrane receptor and is often referred to as DC-SIGN because of its expression on the surface of dendritic cells and macrophages. Additionally we are shipping CD209 Molecule Antibodies (281) and CD209 Molecule Kits (7) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
Rat CD209 CD209 288379  
CD209 30835 Q9NNX6
Mouse CD209 CD209 170786 Q91ZX1
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Top CD209 Molecule Proteins at antibodies-online.com

Showing 10 out of 13 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Human Cells Human Fc Tag 100 μg Log in to see 16 Days
$382.80
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 49 to 54 Days
$6,041.49
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Primates His tag   1 mg Log in to see 56 to 66 Days
$2,795.83
Details
Yeast REACT_Green monkey His tag   1 mg Log in to see 56 to 66 Days
$2,867.33
Details
Yeast Macaca nemestrina His tag   1 mg Log in to see 56 to 66 Days
$2,867.33
Details
Yeast Macaca mulatta His tag   1 mg Log in to see 56 to 66 Days
$2,938.83
Details
Yeast Pongo pygmaeus His tag   1 mg Log in to see 56 to 66 Days
$2,938.83
Details
Yeast Pan troglodytes His tag   1 mg Log in to see 56 to 66 Days
$3,010.33
Details

CD209 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , , ,
, , ,

Top referenced CD209 Molecule Proteins

  1. Human CD209 Protein expressed in Human Cells - ABIN2002324 : Geijtenbeek, Torensma, van Vliet, van Duijnhoven, Adema, van Kooyk, Figdor: Identification of DC-SIGN, a novel dendritic cell-specific ICAM-3 receptor that supports primary immune responses. in Cell 2000 (PubMed)
    Show all 5 references for ABIN2002324

More Proteins for CD209 Molecule (CD209) Interaction Partners

Cow (Bovine) CD209 Molecule (CD209) interaction partners

  1. The development and use of CD209 to characterize the phenotype of CD209 expressing cells in bovine blood using flow cytometry is reported.

  2. a DC-SIGN-like molecule expressed specifically by bovine DC. This molecule may play an important role in the infection of bovine (DC) cells with M. bovis.

Pig (Porcine) CD209 Molecule (CD209) interaction partners

  1. The cloning and characterization of the cDNA and gene encoding porcine DC-SIGN (pDC (show PDC Proteins)-SIGN)is reported. The results will help better understand the biological role(s) of DC-SIGN family in innate immunity during the evolutionary process.

Zebrafish CD209 Molecule (CD209) interaction partners

  1. identification and functional characterization of DC-SIGN/CD209 molecule in zebrafish

Human CD209 Molecule (CD209) interaction partners

  1. CD209 gene -871A/G is associated with decreased susceptibility to pulmonary tuberculosis (PT) overall; -336A/G polymorphism is associated with increased susceptibility in Asians and -139G/A polymorphism is not associated with susceptibility to PT

  2. The high-mannose N-linked glycan at N154 of Japanese encephalitis virus E glycoprotein was shown to be crucial for binding to DC-SIGN and subsequent internalization.

  3. Preliminary study suggests that OAS (show SMOC1 Proteins) gene cluster and CD209 gene polymorphisms influence the risk of developing clinical symptoms in Chikungunya virus-infected patients.

  4. DC-SIGN can promote the maturation and activation of dendritic cells on recognition of hepatitis B virus, but wild type virus can escape recognition by DC-SIGN to a certain extent with the help of demannosylated modification.

  5. Colorectal mucus can bind the C-type lectin (show MBL2 Proteins) DC-SIGN and block HIV-1 trans-infection of both CCR5 and CXCR4 (show CXCR4 Proteins) using HIV-1 strains.

  6. Engagement of sIg (show PICALM Proteins) in FL cells or normal B cells by anti-Ig led to endocytosis in vitro as expected, but DC-SIGN, even when cross-linked, did not lead to significant endocytosis of sIg (show PICALM Proteins)

  7. M2 macrophages induced a DC-SIGN-dependent adhesion of highly mannosylated IgM(+) FL B cells and triggered BCR (show BCR Proteins)-associated kinase activation.

  8. DC-SIGN-induced ISGF3 (show STAT1 Proteins) by fucose-based PAMPs has an essential role in driving IL-27 (show IL27 Proteins) and subsequent TFH polarization, which might be harnessed for vaccination design

  9. selective engagement of dendritic cell-SIGN resulting in intracellular persistence in myeloid dendritic cells; however TLR2 activation can overcome autophagy evasion and pathogen persistence in dendritic cells

  10. High-resolution crystal structures of the SIGN-R1 carbohydrate recognition domain show 2 binding sites allowing SIGNR1 (show CD209B Proteins) to simultaneously bind both immune glycoproteins and microbial polysaccharide components.

Rhesus Monkey CD209 Molecule (CD209) interaction partners

  1. DC-SIGN+ cells showed a clear differential distribution in the decidua in the first 2 weeks of pregnancy, being found only adjacent to the implantation site

  2. DC-SIGN expression in mesenteric lymph nodes is significantly downregulated in simian immunodeficiency virus-infected pig-tailed macaques.

Mouse (Murine) CD209 Molecule (CD209) interaction partners

  1. results suggested that podocytes in lupus nephritis can exert dendritic cell-like function through their expression of DC-SIGN, which may be involved in immune and inflammatory responses of renal tissues

  2. High-resolution crystal structures of the SIGN-R1 carbohydrate recognition domain show 2 binding sites allowing SIGNR1 (show CD209B Proteins) to simultaneously bind both immune glycoproteins and microbial polysaccharide components.

  3. Data suggest that serum amyloid P (SAP (show APCS Proteins)) activates CD209 DC-SIGN to regulate the innate immune system differently from C-reactive protein (CRP (show CRP Proteins)), and that DC-SIGN is a target for antifibrotics.

  4. Intestinal enterocytes regulate tissue-associated immune compartments under the control of DC-SIGN in inflammatory bowel disease.

  5. In vivo T cell activation induces the formation of CD209(+) PDL-2 (show PDCD1LG2 Proteins)(+) dendritic cells.

  6. CD209a expression on dendritic cells is critical for the development of pathogenic Th17 cell responses in murine schistosomiasis.

  7. CD209a is activated in macrophages by LECT2 (show LECT2 Proteins).

  8. The neck region of the C-type lectin DC-SIGN regulates its surface spatiotemporal organization and virus-binding capacity on antigen-presenting cells

  9. interactions between the CRD (show CRX Proteins) of DC-SIGN and the extracellular matrix and/or cis (show CISH Proteins) interactions with transmembrane scaffolding protein(s) play an essential role in organizing these microdomains

  10. analysis of activated apoptotic cells induce dendritic cell maturation via engagement of Toll-like receptor 4 (TLR4 (show TLR4 Proteins)), dendritic cell-specific intercellular adhesion molecule 3 (ICAM-3 (show ICAM3 Proteins))-grabbing nonintegrin (DC-SIGN), and beta2 integrins

CD209 Molecule (CD209) Protein Profile

Protein Summary

This gene encodes a transmembrane receptor and is often referred to as DC-SIGN because of its expression on the surface of dendritic cells and macrophages. The encoded protein is involved in the innate immune system and recognizes numerous evolutionarily divergent pathogens ranging from parasites to viruses with a large impact on public health. The protein is organized into three distinct domains: an N-terminal transmembrane domain, a tandem-repeat neck domain and C-type lectin carbohydrate recognition domain. The extracellular region consisting of the C-type lectin and neck domains has a dual function as a pathogen recognition receptor and a cell adhesion receptor by binding carbohydrate ligands on the surface of microbes and endogenous cells. The neck region is important for homo-oligomerization which allows the receptor to bind multivalent ligands with high avidity. Variations in the number of 23 amino acid repeats in the neck domain of this protein are rare but have a significant impact on ligand binding ability. This gene is closely related in terms of both sequence and function to a neighboring gene (GeneID 10332\; often referred to as L-SIGN). DC-SIGN and L-SIGN differ in their ligand-binding properties and distribution. Alternative splicing results in multiple variants.

Gene names and symbols associated with CD209 Molecule Proteins (CD209)

  • CD209 molecule (CD209)
  • CD209 antigen (Cd209)
  • CD209-like protein (cd209)
  • CD209 molecule (cd209)
  • CD209 (dc-sign)
  • CD209a antigen (Cd209a)
  • CD209c molecule (Cd209c)
  • Cd209 protein
  • CDSIGN protein
  • CIRE protein
  • CLEC4L protein
  • CLEC4M protein
  • DC-SIGN protein
  • DC-SIGN1 protein
  • Dcsign protein
  • si:ch211-224h1.3 protein
  • SIGN-R1 protein
  • SIGNR5 protein

Protein level used designations for CD209 Molecule Proteins (CD209)

CD209 antigen , CD209-like protein , C-type lectin domain family 4, member M , DC-SIGN protein , CD209 , C-type lectin domain family 4 member L , C-type lectin domain family 4, member L , HIV gpl20-binding protein , dendritic cell-specific ICAM-3-grabbing non-integrin 1 , dendritic cell-specific intracellular adhesion molecules (ICAM)-3 grabbing non-integrin , DC-SIGN1 , dendritic cell-specific ICAM-3 grabbing non-integrin , putative mannose-binding C-type lectin , CD209 antigen-like protein A , dendritic cell-specific ICAM-3-grabbing non-integrin , CD209 antigen-like protein C , CD209c antigen

GENE ID SPECIES
100460708 Pongo abelii
288379 Rattus norvegicus
100136662 Oncorhynchus mykiss
485000 Canis lupus familiaris
513266 Bos taurus
100170134 Sus scrofa
100334918 Danio rerio
100462978 Felis catus
100529184 Oryzias latipes
30835 Homo sapiens
450160 Pan troglodytes
574211 Macaca mulatta
170786 Mus musculus
688951 Rattus norvegicus
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