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Mediates B-cell B-cell interactions. Additionally we are shipping CD22 Antibodies (667) and CD22 Kits (23) and many more products for this protein.
Showing 10 out of 28 products:
Human CD22 Protein expressed in HEK-293 Cells - ABIN2180726
Hatta, Tsuchiya, Matsushita, Shiota, Hagiwara, Tokunaga: Identification of the gene variations in human CD22. in Immunogenetics 1999
Show all 3 references for ABIN2180726
Mouse (Murine) CD22 Protein expressed in Human Cells - ABIN2008736
Nitschke: CD22 and Siglec-G: B-cell inhibitory receptors with distinct functions. in Immunological reviews 2009
Show all 2 references for ABIN2008736
Cynomolgus CD22 Protein expressed in Human Cells - ABIN2010039
Tedder, Poe, Haas: CD22: a multifunctional receptor that regulates B lymphocyte survival and signal transduction. in Advances in immunology 2005
Show all 2 references for ABIN2010039
This combined approach suggests that the inhibitory function of CD22 is influenced by its nanoscale organization and is ensured by its fast diffusion enabling a "global BCR (show BCR Proteins) surveillance" at the plasma membrane.
results demonstrate that loss of high affinity CD22 ligands on GC B (show NPR2 Proteins)-cells occurs in both mice and humans through alternative mechanisms, unmasking CD22 relative to naive and memory B-cells
A noncatalytic role for CD45 (show PTPRC Proteins) in regulating tonic, but not antigen-mediated, B-cell antigen receptor (BCR (show BCR Proteins)) signaling through modulation of the function of the inhibitory coreceptor CD22, was identified.
CD22 is recruited to the immunological synapse by sialic acid ligands on the Ag-bearing cells, producing a tolerogenic signal involving Lyn (show LYN Proteins) and the proapoptotic factor BIM (show BCL2L11 Proteins) that promotes deletion of the B cell and failure of mice to develop Abs to the Ag upon subsequent challenge.
These data assign a key role to CCL22 (show CCL22 Proteins) in Treg recruitment in the protection of NOD mice against type 1 diabetes following the treatment with G-CSF (show CSF3 Proteins).
Thus, CD22 plays an essential role in controlling West Nile virus infection by governing cell migration and CD8 (show CD8A Proteins)(+) T cell responses.
that neither B cells nor CD22 are critical for the immediate antiinflammatory activity of IVIgs in mouse models of rheumatoid arthritis and ITP (show ITPA Proteins).
Increased red cell turnover in a line of CD22-deficient mice is caused by Gpi1c: a model for hereditary haemolytic anaemia.
novel expression pattern and tissue eosinophilia-regulating function for the "B cell-specific" inhibitory molecule CD22 on GI eosinophils.
As a receptor for sIgM, CD22 induces a negative feedback loop for B-cell activation (show BLNK Proteins)/
Siglec-1 (show SIGLEC1 Proteins) and Siglec-2 are potential biomarkers in autoimmune disease. (Review)
We aimed to screen exons 9-14 of the CD22 gene, which is a mutational hot spot region in B-precursor acute lymphoblastic leukemia (pre-B ALL) patients. Nine variants, of which two novel, were found. Novel variants were in introns 10 and 13. Gly745Asp (rs10406069) variant was missense and Cys790Arg (rs79438722) variant was silent.
Anti-CD22-magnetic nanoparticles-doxorubicin inhibited the proliferation of Raji cells, significantly increased the uptake of doxorubicin, and induced apoptosis.
MicroRNA-19a and CD22 Comprise a Feedback Loop for B Cell Response in Sepsis.
These results suggest that the in vivo mechanism of non-ligand-blocking epratuzumab may, in part, involve the unmasking of CD22 to facilitate the trans-interaction of B cells with vascular endothelium.
By using integrative genomics and analysing the relationships of COPD (show ARCN1 Proteins) phenotypes with SNPs and gene expression in lung tissue, we identified CST3 (show CST3 Proteins) and CD22 as potential causal genes for airflow obstruction.
study detected the expression of CD22 and CD72 (show CD72 Proteins) on B cells of myasthenia gravis, compared to multiple sclerosis patient controls and healthy controls y
In the absence of functional CD22, B cells have a "hyperactivated" phenotype, CD22 dysfunction could contribute to the pathogenesis of autoimmune diseases. (Review)
The finding that CD22 is expressed on lung cancer cells is significant in revealing a heretofore unknown mechanism of tumorigenesis and metastasis
Mediates B-cell B-cell interactions. May be involved in the localization of B-cells in lymphoid tissues. Binds sialylated glycoproteins\; one of which is CD45. Preferentially binds to alpha-2,6-linked sialic acid. The sialic acid recognition site can be masked by cis interactions with sialic acids on the same cell surface. Upon ligand induced tyrosine phosphorylation in the immune response seems to be involved in regulation of B-cell antigen receptor signaling. Plays a role in positive regulation through interaction with Src family tyrosine kinases and may also act as an inhibitory receptor by recruiting cytoplasmic phosphatases via their SH2 domains that block signal transduction through dephosphorylation of signaling molecules.
B-cell receptor CD22
, B-lymphocyte cell adhesion molecule
, T-cell surface antigen Leu-14
, sialic acid-binding Ig-like lectin 2
, CD22 antigen
, sialic acid binding Ig-like lectin 2
, Sialic acid-binding Ig-like lectin 2