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CD244 Molecule, Natural Killer Cell Receptor 2B4 Proteins (CD244)

CD244 encodes a cell surface receptor expressed on natural killer (NK) cells (and some T cells) that mediate non-major histocompatibility complex (MHC) restricted killing. Additionally we are shipping CD244 Antibodies (127) and CD244 Kits (8) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
CD244 51744 Q9BZW8
CD244 64025 Q9JLM2
CD244 18106 Q07763
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Top CD244 Proteins at antibodies-online.com

Showing 10 out of 23 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_HEK-293 Cells Human His tag 100 μg Log in to see 16 to 41 Days
$346.50
Details
HOST_Human Cells Human Fc Tag 100 μg Log in to see 16 Days
$382.80
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 49 to 54 Days
$6,041.49
Details
HOST_Escherichia coli (E. coli) Human His tag 50 μg Log in to see 7 to 8 Days
$319.00
Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 49 to 54 Days
$4,244.78
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_HEK-293 Human His tag 50 μg Log in to see 2 to 3 Days
$630.00
Details
HOST_Escherichia coli (E. coli) Rat His tag,T7 tag 100 μg Log in to see 11 to 13 Days
$785.40
Details
HOST_Wheat germ Human GST tag 2 μg Log in to see 9 Days
$333.33
Details

CD244 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , , , , ,
, , ,
Rat (Rattus) ,
,
Mouse (Murine) ,
,

Top referenced CD244 Proteins

  1. Human CD244 Protein expressed in Human Cells - ABIN2001951 : Lee, Forman, McNerney, Stepp, Kuppireddi, Guzior, Latchman, Sayegh, Yagita, Park, Oh, Wülfing, Schatzle, Mathew, Sharpe, Kumar: Requirement of homotypic NK-cell interactions through 2B4(CD244)/CD48 in the generation of NK effector functions. in Blood 2006 (PubMed)
    Show all 6 references for ABIN2001951

  2. Human CD244 Protein expressed in HEK-293 Cells - ABIN2180730 : Nakajima, Cella, Langen, Friedlein, Colonna: Activating interactions in human NK cell recognition: the role of 2B4-CD48. in European journal of immunology 1999 (PubMed)
    Show all 4 references for ABIN2180730

More Proteins for CD244 Molecule, Natural Killer Cell Receptor 2B4 (CD244) Interaction Partners

Human CD244 Molecule, Natural Killer Cell Receptor 2B4 (CD244) interaction partners

  1. SLAMF4 gene and surface protein expression was down-regulated in CD8 (show CD8A Proteins)+ T cells from SLE patients compared with that in cells obtained from healthy donors. SLAMF4+ effector memory cells produced more granzyme B and perforin (show PRF1 Proteins) than SLAMF4- cells.

  2. GSK-3 undergoes inhibitory phosphorylation at regulatory serine residues by the engagement of NKG2D (show KLRK1 Proteins) and 2B4, either individually or in combination.

  3. Cytomegalovirus-Induced Expression of CD244 after Liver Transplantation Is Associated with CD8 (show CD8A Proteins)+ T Cell Hyporesponsiveness to Alloantigen

  4. CD8 (show CD8A Proteins)(+) T cells require 2B4 for Epstein-Barr virus-specific immune control, because 2B4 blockade after CD8 (show CD8A Proteins)(+) T-cell depletion did not further aggravate symptoms of the infection.

  5. CD244 expression/signaling in tuberculosis correlates with high levels of a long noncoding RNA (lncRNA)-BC050410 [named as lncRNA-AS-GSTT1(1 (show GSTT1 Proteins)-72) or lncRNA-CD244] in the CD244(+)CD8 (show CD8A Proteins)(+) T-cell subpopulation.

  6. show that in addition to NKG2D (show KLRK1 Proteins), human CEACAM1 (show CEACAM1 Proteins) can inhibit NK-cell activation via NKp30 (show NCR3 Proteins) or 2B4

  7. this study investigates the structural requirements for the recruitment of the human-activating NK-cell receptors NKG2D (show KLRK1 Proteins) and 2B4 to detergent-resistant membrane fractions in the murine BA/F3 cell line and in the human NK-cell line NKL (show GLIS2 Proteins).

  8. Study of SAP (show APCS Proteins) expression is specific but may have insufficient sensitivity for screening XLP1 as a single tool; however, combination with 2B4 functional assay allows identification of all cases

  9. Blockade of 2B4/CD48 (show CD48 Proteins) interaction resulted in improvement in function via perforin (show PRF1 Proteins) expression and degranulation as measured by CD107a (show LAMP1 Proteins) surface mobilization on HTLV-1 specific CD8 (show CD8A Proteins)+ T cells.

  10. In patients suffering from X-linked lymphoproliferative disease (XLP1), SAP (show APCS Proteins) is nonfunctional, not only abolishing the activating function of 2B4, but rendering this receptor inhibitory.

Mouse (Murine) CD244 Molecule, Natural Killer Cell Receptor 2B4 (CD244) interaction partners

  1. 2B4 dampens T-independent B cell responses.

  2. DCs from CD244(-/-) mice elicited increased NK cell activation in vitro. These data add CD244 to a growing list of immuno-modulatory receptors found on DCs.

  3. Data show that enforced expression of inhibitor of differentiation protein Id3 (show ID3 Proteins) specifically increased the persistence of Cd244 protein 2B4(+) virus-specific CD8 (show CD8A Proteins)(+) T cells.

  4. Molecular dynamic simulation explains unbinding and unfolding of CD48 (show CD48 Proteins)-2B4 protein complexes.

  5. Signaling via SLAMF4 controls expansion of cytotoxic CD8alphabeta(+) IELs, which regulate the reversible depletion of lamina propria phagocytes and inflammation in the small intestine.

  6. CD244 (2B4) has a regulatory effect on mast cells and eosinophils in murine allergic inflammation.

  7. NKG2D (show KLRK1 Proteins) ligation relieves 2B4-mediated NK-cell self-tolerance in mice.

  8. blockade of CD28 (show CD28 Proteins) signals in the presence of preserved CTLA-4 (show CTLA4 Proteins) signals results in the unique up-regulation of 2B4 on primary CD8 (show CD8A Proteins)(+) effectors, and that this 2B4 expression plays a critical functional role in controlling antigen-specific T8 cell responses

  9. In the absence of SAP (show APCS Proteins), signaling through the SLAM (show SLAMF1 Proteins) family members Ly108 (show SLAMF6 Proteins) and 2B4 resulted in increased recruitment of the SHP-1 (show PTPN6 Proteins) phosphatase, associated with altered SHP-1 (show PTPN6 Proteins) localization and decreased activation of Src (show SRC Proteins) kinases at the synapse.

  10. Ox-LDL significantly promoted the interaction of natural killer cells and dendritic cells via CD48 (show CD48 Proteins)-2B4 contact-dependent mechanisms.

CD244 Protein Profile

Protein Summary

This gene encodes a cell surface receptor expressed on natural killer (NK) cells (and some T cells) that mediate non-major histocompatibility complex (MHC) restricted killing. The interaction between NK-cell and target cells via this receptor is thought to modulate NK-cell cytolytic activity. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with CD244

  • CD244 molecule, natural killer cell receptor 2B4 (CD244)
  • Cd244 molecule, natural killer cell receptor 2B4 (Cd244)
  • CD244 natural killer cell receptor 2B4 (Cd244)
  • 2B4 protein
  • C9.1 protein
  • CD244 protein
  • F730046O15Rik protein
  • Ly90 protein
  • NAIL protein
  • NKR2B4 protein
  • Nmrk protein
  • SLAMF4 protein

Protein level used designations for CD244

CD244 molecule, natural killer cell receptor 2B4 , natural killer cell receptor 2B4 , NK cell activation inducing ligand NAIL , NK cell activation-inducing ligand , NK cell type I receptor protein 2B4 , SLAM family member 4 , h2B4 , signaling lymphocytic activation molecule 4 , CD244 natural killer cell receptor 2B4 , NKR2B4 , non MHC restricted killing associated , non-MHC restricted killing associated , transmembrane NK cell receptor 2B4 , NK cell receptor 2B4

GENE ID SPECIES
488644 Canis lupus familiaris
513468 Bos taurus
100594419 Nomascus leucogenys
51744 Homo sapiens
64025 Rattus norvegicus
18106 Mus musculus
Selected quality suppliers for CD244 Proteins (CD244)
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