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May play a role in angiogenesis or vascular function.. Additionally we are shipping CD248 Proteins (7) and CD248 Kits (2) and many more products for this protein.
Showing 10 out of 86 products:
Human Polyclonal CD248 Primary Antibody for IF, IHC (p) - ABIN500885
Christian, Ahorn, Koehler, Eisenhaber, Rodi, Garin-Chesa, Park, Rettig, Lenter: Molecular cloning and characterization of endosialin, a C-type lectin-like cell surface receptor of tumor endothelium. in The Journal of biological chemistry 2001
Show all 4 references for ABIN500885
Human Polyclonal CD248 Primary Antibody for IHC, ELISA - ABIN1003256
Nanda, St Croix: Tumor endothelial markers: new targets for cancer therapy. in Current opinion in oncology 2003
Show all 4 references for ABIN1003256
Human Polyclonal CD248 Primary Antibody for IHC, ELISA - ABIN1003255
Rettig, Garin-Chesa, Healey, Su, Jaffe, Old: Identification of endosialin, a cell surface glycoprotein of vascular endothelial cells in human cancer. in Proceedings of the National Academy of Sciences of the United States of America 1992
Show all 4 references for ABIN1003255
Human Polyclonal CD248 Primary Antibody for EIA, IHC (p) - ABIN500887
Nanda, Karim, Peng, Liu, Qiu, Gan, Vogelstein, St Croix, Kinzler, Huso: Tumor endothelial marker 1 (Tem1) functions in the growth and progression of abdominal tumors. in Proceedings of the National Academy of Sciences of the United States of America 2006
Show all 4 references for ABIN500887
suggest that CD248 stromal cells have a pathogenic role in renal fibrosis
We conclude that CD248 is required for PDGFRbeta-dependant capillary sprouting but not splitting angiogenesis, and identify a new role for CD248 expressed on pericytes in the early stages of physiological angiogenesis during muscle remodelling.
Tem1-TT vaccination elicited CD8+ and/or CD4+ T cell responses against immunodominant TEM1 protein sequences. Prophylactic immunization of animals with Tem1-TT prevented or delayed tumor formation in several tumor models.
Expression of CD248 was seen in osteoblasts, but not osteoclasts. CD248(-/-) mouse tibiae had higher bone mass and superior mechanical properties compared to WT mice. Primary osteoblasts from CD248(-/-) mice induced increased bone mineralization
The multiple pathways regulated by the cytoplasmic domain of CD248 highlight its potential as a therapeutic target to treat cancer.
our observations suggest that Tem1 is expressed throughout embryonic and adult development in several types of mesenchymal cells closely related to blood vessels.
Tem1 have significant implications for the mechanisms underlying tumor invasiveness and for models that evaluate this process
In the embryo when analysed by confocal microscopy endosialin on vessels does not colocalise with endothelial cells expressing CD31 (show PECAM1 Antibodies), rather, endosialin is restricted to closely associated perivascular cells that also express the pericyte marker NG2 (show Vcan Antibodies).
CD248 expression helps define a subset of lymphoid tissue stromal cells which play a role in remodelling during tissue development, infection and repair
TEM1 expression in cancer-associated fibroblasts is correlated with a poor prognosis in patients with gastric cancer
MORAb-004 reduced CD248 on pericytes, impaired tumor microvasculature maturation and ultimately suppressed tumor development.
The authors show that endosialin, a C-type lectin (show MBL2 Antibodies), expressed in the liver exclusively by HSC (show FUT1 Antibodies) and portal fibroblasts, is upregulated in liver fibrosis in mouse and man.
The genes CD248, Ephb1 (show EPHB1 Antibodies) and P2RY2 (show P2RY2 Antibodies) were detected as the top overexpressed in GC biopsies.
new monoclonal antibodies described in this paper are domain-specific and represent important reagents for the study of functional contributions of extracellular endosialin domains
[review] CD248 is a C-type lectin (show MBL2 Antibodies)-like domain-containing cell surface glycoprotein (show GJA8 Antibodies) that is expressed by stromal cells of proliferating tissues during embryogenesis and postnatally in tumors and inflammatory lesions.
CD248 defines a subset of stromal cells, including but not limited to some myofibroblasts, linked to albuminuria and tubulointerstitial damage during tissue remodeling in CKD.
endosialin can be detected in advanced sarcoma
Endosialin expression may be involved in the progression of rectal cancers.
Results provide evidence for a TEM-1-dependent signal pathway that controls proliferation of pericytes.
May play a role in angiogenesis or vascular function.
CD164 sialomucin-like 1
, CD248 antigen, endosialin
, tumor endothelial marker 1