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Involved in the costimulatory signal essential for T- cell proliferation and IFNG production in a PDCD1-independent manner. Additionally we are shipping PD-L1 Proteins (71) and PD-L1 Kits (27) and many more products for this protein.
Showing 10 out of 328 products:
Human Monoclonal PD-L1 Primary Antibody for FACS, IHC (p) - ABIN1449244
Mandavilli: Hormone in the hot seat. in Nature medicine 2006
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Human Polyclonal PD-L1 Primary Antibody for IF, IHC (p) - ABIN500467
Chentoufi, Kritzer, Tran, Dasgupta, Lim, Yu, Afifi, Jiang, Carpenter, Osorio, Hsiang, Nesburn, Wechsler, BenMohamed: The herpes simplex virus 1 latency-associated transcript promotes functional exhaustion of virus-specific CD8+ T cells in latently infected trigeminal ganglia: a novel immune evasion mechanism. in Journal of virology 2011
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Human Polyclonal PD-L1 Primary Antibody for EIA, WB - ABIN401427
Holling, Schooten, van Den Elsen: Function and regulation of MHC class II molecules in T-lymphocytes: of mice and men. in Human immunology 2004
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Human Monoclonal PD-L1 Primary Antibody for IHC (p), ELISA - ABIN1995635
Soliman, Khalil, Antonia: PD-L1 expression is increased in a subset of basal type breast cancer cells. in PLoS ONE 2014
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Human Polyclonal PD-L1 Primary Antibody for IHC, ELISA - ABIN185339
Thompson, Gillett, Cheville, Lohse, Dong, Webster, Krejci, Lobo, Sengupta, Chen, Zincke, Blute, Strome, Leibovich, Kwon: Costimulatory B7-H1 in renal cell carcinoma patients: Indicator of tumor aggressiveness and potential therapeutic target. in Proceedings of the National Academy of Sciences of the United States of America 2004
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Human Monoclonal PD-L1 Primary Antibody for FACS - ABIN2853592
del Rio, Rodriguez-Barbosa, Kremmer, Förster: CD103- and CD103+ bronchial lymph node dendritic cells are specialized in presenting and cross-presenting innocuous antigen to CD4+ and CD8+ T cells. in Journal of immunology (Baltimore, Md. : 1950) 2007
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Mouse (Murine) Monoclonal PD-L1 Primary Antibody for FACS - ABIN317020
Kanai, Totsuka, Uraushihara, Makita, Nakamura, Koganei, Fukushima, Akiba, Yagita, Okumura, Machida, Iwai, Azuma, Chen, Watanabe: Blockade of B7-H1 suppresses the development of chronic intestinal inflammation. in Journal of immunology (Baltimore, Md. : 1950) 2003
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Human Monoclonal PD-L1 Primary Antibody for FACS - ABIN1449174
Iwai, Okazaki, Nishimura, Kawasaki, Yagita, Honjo: Microanatomical localization of PD-1 in human tonsils. in Immunology letters 2002
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PD-1 (show PDCD1 Antibodies)/PD-L1 plays a crucial role in maintaining immune tolerance induced by UVB-iDCs, as well as in actively controlling effector T cells specific to alloantigens.
Data show that Qiyusanlong decoction (QYSL) can moderately inhibit the growth of the transplanted tumor by decreasing programmed death 1 (show PDCD1 Antibodies) and programmed death ligand 1 (PD-1 (show PDCD1 Antibodies)/PD-L1) level.
Expression of PD-L1 is correlated with the severity of periodontitis in the mouse model of experimental periodontitis.
Blockade of TGFbeta (show TGFB1 Antibodies) downregulated PD-1 (show PDCD1 Antibodies) and PD-L1 expression and precipitated graft rejection.
Loss of Cdk5 (show CDK5 Antibodies) results in persistent expression of the PD-L1 transcriptional repressors, the interferon (show IFNA Antibodies) regulatory factors IRF2 (show IRF2 Antibodies) and IRF2BP2 (show IRF2BP2 Antibodies), which likely leads to reduced PD-L1 expression on tumors.
The endogenous PD-1 (show PDCD1 Antibodies)/PD-L pathway does not limit acute experimental foreign antigen-induced circulating immune complex glomerulonephritis.
addition to inhibiting T cells, hepatic stellate cells (HSCs) concurrently inhibit B cells via PD-L1; this direct B cell-inhibitory activity of HSCs should contribute to the mechanism by which HSCs maintain the liver's immune homeostasis
The results demonstrated that blockade of PD-1 (show PDCD1 Antibodies)/B7H1 pathway could promote mouse NK cells to kill the GL261GSCs, and the PD-1 (show PDCD1 Antibodies)-inhibited NK cells could be a feasible immune therapeutic approach against Glioblastoma multiforme.
These findings provide evidence for a novel immune escape mechanism during acute retroviral infection based on PD-L1 expression levels on virus infected target cells
These results suggest a novel and specific role for PspA (show SFTPA1 Antibodies) in modulating immune responses against S. pneumoniae by regulating PD-L1 expression.
The B7-H1 and B7-DC (show PDCD1LG2 Antibodies) staining was located in areas of the tissue that were identified.
PD-L1 expression was not prognostic in the overall cohort. PD-L1 expression in primary tumor and matched nodal specimens were highly concordant. The observed survival benefit in N2 disease requires confirmation
our study is the first and largest study to demonstrate overexpression of a targetable checkpoint protein, PD-L1 in metaplastic breast carcinoma
We found that high PD-L1 expression was a poor prognostic factor in the smokers with lung adenocarcinomaor the patients with wild-type EGFR (show EGFR Antibodies), whereas it was not the case in those who never smoked or those with EGFR (show EGFR Antibodies) mutation, implying the importance of adenocarcinoma driver mutations and etiology.
this study shows that serum PD-L1 may reflect sepsis disease severity, and serve as an independent prognostic factor for 28-days mortality
in a population of patients with non-small-cell lung cancer, the pattern of PD-L1 expression was heterogeneous, represented by two distinct cell types: the tumor cell (higher frequency) and IICs (lowest frequency). Positive PD-L1 expression was observed in 37.9% of tumor cells and in IICs of 24.3% of tumors.
The mRNA expression of PD-L1 in primary nephrectomy specimens revealed no significant association with unfavourable clinical parameters. Interestingly, though, a positive correlation with patient survival was found (HR=0,59, p=0,006).
Case Report: Metastatic lymphoepithelioma-like hepatocellular carcinoma is associated with PD-L1 expression.
expression of MDM2 (show MDM2 Antibodies), somatostatin (show SST Antibodies) receptor 2A, and PD-L1 in follicular dendritic cell sarcoma
In triple-negative breast cancer, stromal PD-L1 expression was associated with better disease-free survival.
role of programmed death ligand-1 (PD-L1) during porcine circovirus type 2 (PCV2) infection and porcine circovirus associated diseases (PCVAD) development
These data suggest that overexpression of PD-L1 and PD-L2 (show PDCD1LG2 Antibodies) mRNA is one mechanism by which immunosupression of postweaning multisystemic wasting syndrome pigs occurs.
Retinal PLD1 expression is enhanced in radial fibers of Muller cells with age. This finding suggests that PLD1 plays an important role in signal transduction of glial cells and neuronal cells in the retina.
A porcine PD-L1 molecule was cloned using RACE (rapid amplification of cDNA ends) technology and sequenced (GenBank # AY837780); it showed high sequence homology with human PD-L1.
This study provides novel information for the understanding of signalling through PD-L1.
Involved in the costimulatory signal essential for T- cell proliferation and IFNG production in a PDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation by blocking cell cycle progression and cytokine production.
, CD274 antigen
, programmed cell death 1 ligand 1
, programmed cell death ligand 1
, B7 homolog 1
, PDCD1 ligand 1
, programmed death ligand 1