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Involved in the costimulatory signal essential for T- cell proliferation and IFNG production in a PDCD1-independent manner. Additionally we are shipping PD-L1 Proteins (64) and PD-L1 Kits (25) and many more products for this protein.
Showing 10 out of 320 products:
Human Monoclonal PD-L1 Primary Antibody for FACS, IHC (p) - ABIN1449244
Mandavilli: Hormone in the hot seat. in Nature medicine 2006
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Human Polyclonal PD-L1 Primary Antibody for IF, IHC (p) - ABIN500467
Chentoufi, Kritzer, Tran, Dasgupta, Lim, Yu, Afifi, Jiang, Carpenter, Osorio, Hsiang, Nesburn, Wechsler, BenMohamed: The herpes simplex virus 1 latency-associated transcript promotes functional exhaustion of virus-specific CD8+ T cells in latently infected trigeminal ganglia: a novel immune evasion mechanism. in Journal of virology 2011
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Human Polyclonal PD-L1 Primary Antibody for EIA, WB - ABIN401427
Holling, Schooten, van Den Elsen: Function and regulation of MHC class II molecules in T-lymphocytes: of mice and men. in Human immunology 2004
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Human Monoclonal PD-L1 Primary Antibody for IHC (p), ELISA - ABIN1995635
Soliman, Khalil, Antonia: PD-L1 expression is increased in a subset of basal type breast cancer cells. in PLoS ONE 2014
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Human Polyclonal PD-L1 Primary Antibody for IHC, ELISA - ABIN185339
Thompson, Gillett, Cheville, Lohse, Dong, Webster, Krejci, Lobo, Sengupta, Chen, Zincke, Blute, Strome, Leibovich, Kwon: Costimulatory B7-H1 in renal cell carcinoma patients: Indicator of tumor aggressiveness and potential therapeutic target. in Proceedings of the National Academy of Sciences of the United States of America 2004
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Human Monoclonal PD-L1 Primary Antibody for FACS - ABIN2853592
del Rio, Rodriguez-Barbosa, Kremmer, Förster: CD103- and CD103+ bronchial lymph node dendritic cells are specialized in presenting and cross-presenting innocuous antigen to CD4+ and CD8+ T cells. in Journal of immunology (Baltimore, Md. : 1950) 2007
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Mouse (Murine) Monoclonal PD-L1 Primary Antibody for FACS - ABIN317020
Kanai, Totsuka, Uraushihara, Makita, Nakamura, Koganei, Fukushima, Akiba, Yagita, Okumura, Machida, Iwai, Azuma, Chen, Watanabe: Blockade of B7-H1 suppresses the development of chronic intestinal inflammation. in Journal of immunology (Baltimore, Md. : 1950) 2003
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Human Monoclonal PD-L1 Primary Antibody for FACS - ABIN1449174
Iwai, Okazaki, Nishimura, Kawasaki, Yagita, Honjo: Microanatomical localization of PD-1 in human tonsils. in Immunology letters 2002
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Data show that Qiyusanlong decoction (QYSL) can moderately inhibit the growth of the transplanted tumor by decreasing programmed death 1 (show PDCD1 Antibodies) and programmed death ligand 1 (PD-1 (show PDCD1 Antibodies)/PD-L1) level.
Expression of PD-L1 is correlated with the severity of periodontitis in the mouse model of experimental periodontitis.
Blockade of TGFbeta (show TGFB1 Antibodies) downregulated PD-1 (show PDCD1 Antibodies) and PD-L1 expression and precipitated graft rejection.
Loss of Cdk5 (show CDK5 Antibodies) results in persistent expression of the PD-L1 transcriptional repressors, the interferon (show IFNA Antibodies) regulatory factors IRF2 (show IRF2 Antibodies) and IRF2BP2 (show IRF2BP2 Antibodies), which likely leads to reduced PD-L1 expression on tumors.
The endogenous PD-1 (show PDCD1 Antibodies)/PD-L pathway does not limit acute experimental foreign antigen-induced circulating immune complex glomerulonephritis.
addition to inhibiting T cells, hepatic stellate cells (HSCs) concurrently inhibit B cells via PD-L1; this direct B cell-inhibitory activity of HSCs should contribute to the mechanism by which HSCs maintain the liver's immune homeostasis
The results demonstrated that blockade of PD-1 (show PDCD1 Antibodies)/B7H1 pathway could promote mouse NK cells to kill the GL261GSCs, and the PD-1 (show PDCD1 Antibodies)-inhibited NK cells could be a feasible immune therapeutic approach against Glioblastoma multiforme.
These findings provide evidence for a novel immune escape mechanism during acute retroviral infection based on PD-L1 expression levels on virus infected target cells
These results suggest a novel and specific role for PspA (show SFTPA1 Antibodies) in modulating immune responses against S. pneumoniae by regulating PD-L1 expression.
Upregulation of PD-1 (show PDCD1 Antibodies) and PD-L1 was associated with marked increases in GADD153 (show DDIT3 Antibodies) during myocardial ischemic reperfusion injury.
CXCL12 (show CXCL12 Antibodies) mRNA level significantly correlated with markers indicating tumour hypoxia in hepatocellular carcinoma. PD-L1 expression was significantly increased in tumours with a high number of tumour-infiltrating lymphocytes. In Cox (show COX8A Antibodies) proportional hazard analyses, high PD-L1 expression and loss of nuclear CXCL12 (show CXCL12 Antibodies) expression showed significant prognostic value in terms of overall survival.
Report immunohistochemical detection of PD-L1 in non-small cell lung cancers and head and neck squamous cell carcinomas.
an IL-27 (show IL27 Antibodies)/Stat3 (show STAT3 Antibodies) axis induces expression of programmed cell death 1 (show PDCD1 Antibodies) ligands (PD-L1/2) on infiltrating macrophages in lymphoma
PD-L1 expression was the only significant independent predictor for longeroverall survival in patients with advanced stage (III/IV) extranodal natural killer/T cell lymphoma
Based on the PD-L1 receptor PD-1 (show PDCD1 Antibodies) expression on tumor-infiltrating cytotoxic cells, our data supported that expression of PD-L1 on TAM (show CCNA1 Antibodies) promoted apoptosis of T cells via interaction with PD-1 (show PDCD1 Antibodies) on CD8 (show CD8A Antibodies)(+)T cells.
PD-L1-positive staining was associated with the depth of invasion, differentiation, and poor prognosis of patients with gastric cancer. PD-L1 staining was significantly correlated with hypoechoic tumor, peripheral invasion, wall thickness, and cancer location in ultrasonography images.
There was no significant association between sPD (show HOXD13 Antibodies)-L1 level and progression-free survival on the first-line treatment of metastatic GC. CONCLUSIONS: High serum levels of sPD (show HOXD13 Antibodies)-L1 correlated with worse overall survival on the first-line chemotherapy in metastatic GC patients
Positive PD-L1 expression was significantly associated with poor disease free survival in salivary gland carcinoma.
The PD-1 (show PDCD1 Antibodies)/PD-L1 checkpoint blockade, which targets regulatory pathways in T cells to overcome immune resistance, is correlated to PD-L1 expression pattern and the presence of tumor-infiltrating lymphocytes (TILs). Meanwhile, immunogenic mutation loads show significant response to checkpoint blockade, which is probably due to PD-1 (show PDCD1 Antibodies)/L1 status and TIL (show TLR1 Antibodies) content
Among 12 SNPs investigated, PD-L1 rs4143815C>G, rs822336G>C, and rs822337T>A were significantly associated with worse survival outcomes in multivariate analyses in early stage non-small cell lung cancer.
role of programmed death ligand-1 (PD-L1) during porcine circovirus type 2 (PCV2) infection and porcine circovirus associated diseases (PCVAD) development
These data suggest that overexpression of PD-L1 and PD-L2 (show PDCD1LG2 Antibodies) mRNA is one mechanism by which immunosupression of postweaning multisystemic wasting syndrome pigs occurs.
Retinal PLD1 expression is enhanced in radial fibers of Muller cells with age. This finding suggests that PLD1 plays an important role in signal transduction of glial cells and neuronal cells in the retina.
A porcine PD-L1 molecule was cloned using RACE (rapid amplification of cDNA ends) technology and sequenced (GenBank # AY837780); it showed high sequence homology with human PD-L1.
This study provides novel information for the understanding of signalling through PD-L1.
Involved in the costimulatory signal essential for T- cell proliferation and IFNG production in a PDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation by blocking cell cycle progression and cytokine production.
, CD274 antigen
, programmed cell death 1 ligand 1
, programmed cell death ligand 1
, B7 homolog 1
, PDCD1 ligand 1
, programmed death ligand 1