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CD274 Molecule Proteins (CD274)

Involved in the costimulatory signal essential for T- cell proliferation and IFNG production in a PDCD1-independent manner. Additionally we are shipping PD-L1 Antibodies (263) and PD-L1 Kits (28) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
CD274 60533 Q9EP73
CD274 29126 Q9NZQ7
CD274 499342  
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Top PD-L1 Proteins at antibodies-online.com

Showing 10 out of 61 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Human Cells Human Fc Tag 100 μg Log in to see 16 Days
$250.80
Details
HOST_Human Cells Mouse His tag,Fc Tag 100 μg Log in to see 16 Days
$250.80
Details
HOST_Human Cells Rat Fc Tag 100 μg Log in to see 16 Days
$272.80
Details
HOST_Human Cells Cynomolgus Fc Tag 100 μg Log in to see 16 Days
$272.80
Details
HOST_HEK-293 Cells Human Strep Tag 25 μg Log in to see 5 Days
$286.00
Details
HOST_HEK-293 Cells Mouse Fc Tag 200 μg Log in to see 2 to 3 Days
$297.00
Details
HOST_Human Cells Rat His tag 100 μg Log in to see 16 Days
$272.80
Details
HOST_Human Cells Cynomolgus His tag 100 μg Log in to see 16 Days
$272.80
Details
HOST_Human Cells Dog Fc Tag 100 μg Log in to see 16 Days
$272.80
Details
HOST_HEK-293 Cells Cynomolgus Fc Tag 100 μg Log in to see 2 to 3 Days
$275.00
Details

CD274 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine) , , , , ,
, , , , , ,
Human , , , , , , , , ,
, , , , , , , , , , , ,
Rat (Rattus)
,

Top referenced PD-L1 Proteins

  1. Mouse (Murine) PD-L1 Protein expressed in Human Cells - ABIN2007141 : Trabattoni, Saresella, Biasin, Boasso, Piacentini, Ferrante, Dong, Maserati, Shearer, Chen, Clerici: B7-H1 is up-regulated in HIV infection and is a novel surrogate marker of disease progression. in Blood 2003 (PubMed)
    Show all 5 references for ABIN2007141

  2. Human PD-L1 Protein expressed in Human Cells - ABIN2002035 : Dong, Zhu, Tamada, Chen: B7-H1, a third member of the B7 family, co-stimulates T-cell proliferation and interleukin-10 secretion. in Nature medicine 1999 (PubMed)
    Show all 4 references for ABIN2002035

  3. Rat (Rattus) PD-L1 Protein expressed in Human Cells - ABIN2009641 : Dong, Strome, Salomao, Tamura, Hirano, Flies, Roche, Lu, Zhu, Tamada, Lennon, Celis, Chen: Tumor-associated B7-H1 promotes T-cell apoptosis: a potential mechanism of immune evasion. in Nature medicine 2002 (PubMed)
    Show all 4 references for ABIN2009641

  4. Dog (Canine) PD-L1 Protein expressed in Human Cells - ABIN2008991 : Tamura, Ogata, Dong, Chen: Immunology of B7-H1 and its roles in human diseases. in International journal of hematology 2003 (PubMed)
    Show all 4 references for ABIN2008991

  5. Cynomolgus PD-L1 Protein expressed in HEK-293 Cells - ABIN2181633 : Freeman, Long, Iwai, Bourque, Chernova, Nishimura, Fitz, Malenkovich, Okazaki, Byrne, Horton, Fouser, Carter, Ling, Bowman, Carreno, Collins, Wood, Honjo: Engagement of the PD-1 immunoinhibitory receptor by a novel B7 family member leads to negative regulation of lymphocyte activation. in The Journal of experimental medicine 2000 (PubMed)
    Show all 2 references for ABIN2181633

  6. Cynomolgus PD-L1 Protein expressed in Human Cells - ABIN2010048 : Holets, Hunt, Petroff: Trophoblast CD274 (B7-H1) is differentially expressed across gestation: influence of oxygen concentration. in Biology of reproduction 2006 (PubMed)

More Proteins for CD274 Molecule (CD274) Interaction Partners

Mouse (Murine) CD274 Molecule (CD274) interaction partners

  1. Blockade of TGFbeta (show TGFB1 Proteins) downregulated PD-1 (show PDCD1 Proteins) and PD-L1 expression and precipitated graft rejection.

  2. Loss of Cdk5 (show CDK5 Proteins) results in persistent expression of the PD-L1 transcriptional repressors, the interferon (show IFNA Proteins) regulatory factors IRF2 (show IRF2 Proteins) and IRF2BP2, which likely leads to reduced PD-L1 expression on tumors.

  3. The endogenous PD-1 (show PDCD1 Proteins)/PD-L pathway does not limit acute experimental foreign antigen-induced circulating immune complex glomerulonephritis.

  4. addition to inhibiting T cells, hepatic stellate cells (HSCs) concurrently inhibit B cells via PD-L1; this direct B cell-inhibitory activity of HSCs should contribute to the mechanism by which HSCs maintain the liver's immune homeostasis

  5. The results demonstrated that blockade of PD-1 (show PDCD1 Proteins)/B7H1 pathway could promote mouse NK cells to kill the GL261GSCs, and the PD-1 (show PDCD1 Proteins)-inhibited NK cells could be a feasible immune therapeutic approach against Glioblastoma multiforme.

  6. These findings provide evidence for a novel immune escape mechanism during acute retroviral infection based on PD-L1 expression levels on virus infected target cells

  7. These results suggest a novel and specific role for PspA (show SFTPA1 Proteins) in modulating immune responses against S. pneumoniae by regulating PD-L1 expression.

  8. Upregulation of PD-1 (show PDCD1 Proteins) and PD-L1 was associated with marked increases in GADD153 (show DDIT3 Proteins) during myocardial ischemic reperfusion injury.

  9. Breg cells can suppress through the PD-1 (show PDCD1 Proteins)/PD-L1 pathway in limiting the differentiation and function of TFH cells

  10. Programmed death 1 (show PDCD1 Proteins)/programmed death ligand 1 pathway likely plays a crucial role in the mechanisms underlying spontaneous tolerization of B cells responding to ABO (show ABO Proteins)-blood group (show DARC Proteins) antigens in liver transplantation.

Human CD274 Molecule (CD274) interaction partners

  1. PD-L1 expression and HLA class I antigen (show MICA Proteins) expression by ICC cells was observed in 8 and 11, respectively, of the 27 tumors analyzed.

  2. Higher CD8 (show CD8A Proteins)+ lymphocyte infiltration was related to lower PD-L1 expression and higher FOXP3 (show FOXP3 Proteins)+ tumor-infiltrating lymphocyte infiltration in breast cancer

  3. Genetic amplification of the PD-L1 gene was correlated with Non-Small Cell Lung Cancer.

  4. High CD274 expression is correlated with glioblastoma.

  5. IL-27 (show IL27 Proteins) induced IDO (show IDO1 Proteins) or PD-L1 expression in monocytes and in human PC3 (show PCSK1 Proteins) prostate and A549 lung cancer cells

  6. PD-L1 expression in neutrophils is elevated in patients with systemic lupus erythematosus.

  7. Immune checkpoint inhibitors, particularly those targeting PD-1 (show PDCD1 Proteins) and PD-L1 are clinically active for the treatment of lung cancer and represent an exciting step forward in lung cancer therapy.

  8. Data show that the serum soluble programmed death-ligand 1 (sPD (show HOXD13 Proteins)-L1) level is a valuable biomarker for predicting treatment response and an independent prognostic factor for progression free survival (PFS).

  9. PD-L1 copy number gain is present in approximately five percent of non-small cell lung cancer with a slight preference to squamous cell carcinoma.

  10. PD-L1 expression is frequently discordant between surgical resected and matched biopsy specimens and thus may be potentially misleading in defining the sensitivity to treatment with PD-L1 targeted therapy.

Pig (Porcine) CD274 Molecule (CD274) interaction partners

  1. role of programmed death ligand-1 (PD-L1) during porcine circovirus type 2 (PCV2) infection and porcine circovirus associated diseases (PCVAD) development

  2. These data suggest that overexpression of PD-L1 and PD-L2 (show PDCD1LG2 Proteins) mRNA is one mechanism by which immunosupression of postweaning multisystemic wasting syndrome pigs occurs.

  3. Retinal PLD1 expression is enhanced in radial fibers of Muller cells with age. This finding suggests that PLD1 plays an important role in signal transduction of glial cells and neuronal cells in the retina.

  4. A porcine PD-L1 molecule was cloned using RACE (rapid amplification of cDNA ends) technology and sequenced (GenBank # AY837780); it showed high sequence homology with human PD-L1.

Cow (Bovine) CD274 Molecule (CD274) interaction partners

  1. This study provides novel information for the understanding of signalling through PD-L1.

PD-L1 (CD274) Protein Profile

Protein Summary

Involved in the costimulatory signal essential for T- cell proliferation and IFNG production in a PDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation by blocking cell cycle progression and cytokine production.

Gene names and symbols associated with CD274 Molecule Proteins (CD274)

  • CD274 molecule (CD274)
  • CD274 molecule (LOC100357106)
  • CD274 antigen (Cd274)
  • CD274 molecule (Cd274)
  • programmed cell death 1 ligand 2 (PDCD1LG2)
  • A530045L16Rik protein
  • B7-H protein
  • B7H1 protein
  • PD-L1 protein
  • PDCD1L1 protein
  • PDCD1LG1 protein
  • PDL1 protein
  • RGD1566211 protein

Protein level used designations for CD274 Molecule Proteins (CD274)

CD274 molecule , CD274 antigen , programmed cell death 1 ligand 1 , programmed cell death ligand 1 , B7 homolog 1 , PDCD1 ligand 1 , programmed death ligand 1

GENE ID SPECIES
427224 Gallus gallus
464981 Pan troglodytes
716043 Macaca mulatta
100126721 Papio anubis
100357106 Oryctolagus cuniculus
60533 Mus musculus
29126 Homo sapiens
499342 Rattus norvegicus
100722088 Cavia porcellus
574058 Sus scrofa
484186 Canis lupus familiaris
533834 Bos taurus
427225 Gallus gallus
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