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Involved in the costimulatory signal essential for T- cell proliferation and IFNG production in a PDCD1-independent manner. Additionally we are shipping PD-L1 Antibodies (300) and PD-L1 Kits (25) and many more products for this protein.
Showing 10 out of 64 products:
Mouse (Murine) PD-L1 Protein expressed in Human Cells - ABIN2007141
Trabattoni, Saresella, Biasin, Boasso, Piacentini, Ferrante, Dong, Maserati, Shearer, Chen, Clerici: B7-H1 is up-regulated in HIV infection and is a novel surrogate marker of disease progression. in Blood 2003
Show all 5 references for ABIN2007141
Human PD-L1 Protein expressed in Human Cells - ABIN2002035
Dong, Zhu, Tamada, Chen: B7-H1, a third member of the B7 family, co-stimulates T-cell proliferation and interleukin-10 secretion. in Nature medicine 1999
Show all 4 references for ABIN2002035
Rat (Rattus) PD-L1 Protein expressed in Human Cells - ABIN2009641
Dong, Strome, Salomao, Tamura, Hirano, Flies, Roche, Lu, Zhu, Tamada, Lennon, Celis, Chen: Tumor-associated B7-H1 promotes T-cell apoptosis: a potential mechanism of immune evasion. in Nature medicine 2002
Show all 4 references for ABIN2009641
Rat (Rattus) PD-L1 Protein expressed in Human Cells - ABIN2009643
Tamura, Ogata, Dong, Chen: Immunology of B7-H1 and its roles in human diseases. in International journal of hematology 2003
Show all 4 references for ABIN2009643
Cynomolgus PD-L1 Protein expressed in HEK-293 Cells - ABIN2181631
Freeman, Long, Iwai, Bourque, Chernova, Nishimura, Fitz, Malenkovich, Okazaki, Byrne, Horton, Fouser, Carter, Ling, Bowman, Carreno, Collins, Wood, Honjo: Engagement of the PD-1 immunoinhibitory receptor by a novel B7 family member leads to negative regulation of lymphocyte activation. in The Journal of experimental medicine 2000
Show all 2 references for ABIN2181631
Cynomolgus PD-L1 Protein expressed in Human Cells - ABIN2010048
Holets, Hunt, Petroff: Trophoblast CD274 (B7-H1) is differentially expressed across gestation: influence of oxygen concentration. in Biology of reproduction 2006
Data show that Qiyusanlong decoction (QYSL) can moderately inhibit the growth of the transplanted tumor by decreasing programmed death 1 (show PDCD1 Proteins) and programmed death ligand 1 (PD-1 (show PDCD1 Proteins)/PD-L1) level.
Expression of PD-L1 is correlated with the severity of periodontitis in the mouse model of experimental periodontitis.
Blockade of TGFbeta (show TGFB1 Proteins) downregulated PD-1 (show PDCD1 Proteins) and PD-L1 expression and precipitated graft rejection.
Loss of Cdk5 (show CDK5 Proteins) results in persistent expression of the PD-L1 transcriptional repressors, the interferon (show IFNA Proteins) regulatory factors IRF2 (show IRF2 Proteins) and IRF2BP2, which likely leads to reduced PD-L1 expression on tumors.
The endogenous PD-1 (show PDCD1 Proteins)/PD-L pathway does not limit acute experimental foreign antigen-induced circulating immune complex glomerulonephritis.
addition to inhibiting T cells, hepatic stellate cells (HSCs) concurrently inhibit B cells via PD-L1; this direct B cell-inhibitory activity of HSCs should contribute to the mechanism by which HSCs maintain the liver's immune homeostasis
The results demonstrated that blockade of PD-1 (show PDCD1 Proteins)/B7H1 pathway could promote mouse NK cells to kill the GL261GSCs, and the PD-1 (show PDCD1 Proteins)-inhibited NK cells could be a feasible immune therapeutic approach against Glioblastoma multiforme.
These findings provide evidence for a novel immune escape mechanism during acute retroviral infection based on PD-L1 expression levels on virus infected target cells
These results suggest a novel and specific role for PspA (show SFTPA1 Proteins) in modulating immune responses against S. pneumoniae by regulating PD-L1 expression.
Upregulation of PD-1 (show PDCD1 Proteins) and PD-L1 was associated with marked increases in GADD153 (show DDIT3 Proteins) during myocardial ischemic reperfusion injury.
Detailed evidence on the frequency of PD-L1 expression in surgically resected small cell lung cancer.
Programmed cell death protein 1 (PD1 (show PDCD1 Proteins)) and programmed death-ligand 1 (PDL1) status by immunohistochemistry was not associated with outcomes. The use of immune checkpoint blockade in tumors with higher mutational load was associated with improved OS. Our results suggest that the evaluation of tumor genomes may be predictive of immunotherapy benefit
This study provides important evidence on the prognostic value of the PD-L1 expression in resected SCLC patients.
Study demonstrates that PD-1 (show PDCD1 Proteins)(+) TIMC and intratumoral PD-L1(+) expression did not significantly impact tumor aggressiveness or clinical outcome in non-ccRCC specimens.
Immune surveillance is an important mechanism in prevention of cancer development and inhibition of growth of tumors and metastasis. Checkpoint pathways prevent immune response through multiple methods including CTLA-4 (show CTLA4 Proteins) and PD-1 (show PDCD1 Proteins)/PD-L1 pathways.A variety of immune checkpoint inhibitors (PD-1 (show PDCD1 Proteins)/PD-L1 and CTLA-4 (show CTLA4 Proteins) inhibitors) have been studied in recurrent and metastatic head and neck cancers with encouraging efficacy
n combination with anti-PD-1 (show PDCD1 Proteins)/PD-L1, the CTLA-4 (show CTLA4 Proteins)-expanded T cells are prevented from being functionally inhibited when they enter into the tumor microenvironment.
The CTLA-4 (show CTLA4 Proteins) receptor was one of the first checkpoint inhibitors to be targeted with limited exploration and efficacy in sarcoma.The PD-1 (show PDCD1 Proteins)/PD-L1 immunologic checkpoint pathway has demonstrated efficacy in many malignancies; studies are ongoing in sarcoma.
High CD274 expression is associated with gliomas.
We provide first evidence that expression of the therapy target PD-L1 is not only highly prevalent in primary prostate cancer cells but is also an independent indicator of BCR (show BCR Proteins), suggesting a biologic relevance in primary tumors.
High PD-L1 expression is Correlated with Non-Small Cell Lung Cancer.
role of programmed death ligand-1 (PD-L1) during porcine circovirus type 2 (PCV2) infection and porcine circovirus associated diseases (PCVAD) development
These data suggest that overexpression of PD-L1 and PD-L2 (show PDCD1LG2 Proteins) mRNA is one mechanism by which immunosupression of postweaning multisystemic wasting syndrome pigs occurs.
Retinal PLD1 expression is enhanced in radial fibers of Muller cells with age. This finding suggests that PLD1 plays an important role in signal transduction of glial cells and neuronal cells in the retina.
A porcine PD-L1 molecule was cloned using RACE (rapid amplification of cDNA ends) technology and sequenced (GenBank # AY837780); it showed high sequence homology with human PD-L1.
This study provides novel information for the understanding of signalling through PD-L1.
Involved in the costimulatory signal essential for T- cell proliferation and IFNG production in a PDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation by blocking cell cycle progression and cytokine production.
, CD274 antigen
, programmed cell death 1 ligand 1
, programmed cell death ligand 1
, B7 homolog 1
, PDCD1 ligand 1
, programmed death ligand 1