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Involved in the costimulatory signal essential for T- cell proliferation and IFNG production in a PDCD1-independent manner. Additionally we are shipping PD-L1 Antibodies (263) and PD-L1 Kits (28) and many more products for this protein.
Showing 10 out of 61 products:
Mouse (Murine) PD-L1 Protein expressed in Human Cells - ABIN2007141
Trabattoni, Saresella, Biasin, Boasso, Piacentini, Ferrante, Dong, Maserati, Shearer, Chen, Clerici: B7-H1 is up-regulated in HIV infection and is a novel surrogate marker of disease progression. in Blood 2003
Show all 5 references for ABIN2007141
Human PD-L1 Protein expressed in Human Cells - ABIN2002035
Dong, Zhu, Tamada, Chen: B7-H1, a third member of the B7 family, co-stimulates T-cell proliferation and interleukin-10 secretion. in Nature medicine 1999
Show all 4 references for ABIN2002035
Rat (Rattus) PD-L1 Protein expressed in Human Cells - ABIN2009641
Dong, Strome, Salomao, Tamura, Hirano, Flies, Roche, Lu, Zhu, Tamada, Lennon, Celis, Chen: Tumor-associated B7-H1 promotes T-cell apoptosis: a potential mechanism of immune evasion. in Nature medicine 2002
Show all 4 references for ABIN2009641
Dog (Canine) PD-L1 Protein expressed in Human Cells - ABIN2008991
Tamura, Ogata, Dong, Chen: Immunology of B7-H1 and its roles in human diseases. in International journal of hematology 2003
Show all 4 references for ABIN2008991
Cynomolgus PD-L1 Protein expressed in HEK-293 Cells - ABIN2181633
Freeman, Long, Iwai, Bourque, Chernova, Nishimura, Fitz, Malenkovich, Okazaki, Byrne, Horton, Fouser, Carter, Ling, Bowman, Carreno, Collins, Wood, Honjo: Engagement of the PD-1 immunoinhibitory receptor by a novel B7 family member leads to negative regulation of lymphocyte activation. in The Journal of experimental medicine 2000
Show all 2 references for ABIN2181633
Cynomolgus PD-L1 Protein expressed in Human Cells - ABIN2010048
Holets, Hunt, Petroff: Trophoblast CD274 (B7-H1) is differentially expressed across gestation: influence of oxygen concentration. in Biology of reproduction 2006
Blockade of TGFbeta (show TGFB1 Proteins) downregulated PD-1 (show PDCD1 Proteins) and PD-L1 expression and precipitated graft rejection.
Loss of Cdk5 (show CDK5 Proteins) results in persistent expression of the PD-L1 transcriptional repressors, the interferon (show IFNA Proteins) regulatory factors IRF2 (show IRF2 Proteins) and IRF2BP2, which likely leads to reduced PD-L1 expression on tumors.
The endogenous PD-1 (show PDCD1 Proteins)/PD-L pathway does not limit acute experimental foreign antigen-induced circulating immune complex glomerulonephritis.
addition to inhibiting T cells, hepatic stellate cells (HSCs) concurrently inhibit B cells via PD-L1; this direct B cell-inhibitory activity of HSCs should contribute to the mechanism by which HSCs maintain the liver's immune homeostasis
The results demonstrated that blockade of PD-1 (show PDCD1 Proteins)/B7H1 pathway could promote mouse NK cells to kill the GL261GSCs, and the PD-1 (show PDCD1 Proteins)-inhibited NK cells could be a feasible immune therapeutic approach against Glioblastoma multiforme.
These findings provide evidence for a novel immune escape mechanism during acute retroviral infection based on PD-L1 expression levels on virus infected target cells
These results suggest a novel and specific role for PspA (show SFTPA1 Proteins) in modulating immune responses against S. pneumoniae by regulating PD-L1 expression.
Upregulation of PD-1 (show PDCD1 Proteins) and PD-L1 was associated with marked increases in GADD153 (show DDIT3 Proteins) during myocardial ischemic reperfusion injury.
Breg cells can suppress through the PD-1 (show PDCD1 Proteins)/PD-L1 pathway in limiting the differentiation and function of TFH cells
Programmed death 1 (show PDCD1 Proteins)/programmed death ligand 1 pathway likely plays a crucial role in the mechanisms underlying spontaneous tolerization of B cells responding to ABO (show ABO Proteins)-blood group (show DARC Proteins) antigens in liver transplantation.
PD-L1 expression and HLA class I antigen (show MICA Proteins) expression by ICC cells was observed in 8 and 11, respectively, of the 27 tumors analyzed.
Higher CD8 (show CD8A Proteins)+ lymphocyte infiltration was related to lower PD-L1 expression and higher FOXP3 (show FOXP3 Proteins)+ tumor-infiltrating lymphocyte infiltration in breast cancer
Genetic amplification of the PD-L1 gene was correlated with Non-Small Cell Lung Cancer.
High CD274 expression is correlated with glioblastoma.
IL-27 (show IL27 Proteins) induced IDO (show IDO1 Proteins) or PD-L1 expression in monocytes and in human PC3 (show PCSK1 Proteins) prostate and A549 lung cancer cells
PD-L1 expression in neutrophils is elevated in patients with systemic lupus erythematosus.
Immune checkpoint inhibitors, particularly those targeting PD-1 (show PDCD1 Proteins) and PD-L1 are clinically active for the treatment of lung cancer and represent an exciting step forward in lung cancer therapy.
Data show that the serum soluble programmed death-ligand 1 (sPD (show HOXD13 Proteins)-L1) level is a valuable biomarker for predicting treatment response and an independent prognostic factor for progression free survival (PFS).
PD-L1 copy number gain is present in approximately five percent of non-small cell lung cancer with a slight preference to squamous cell carcinoma.
PD-L1 expression is frequently discordant between surgical resected and matched biopsy specimens and thus may be potentially misleading in defining the sensitivity to treatment with PD-L1 targeted therapy.
role of programmed death ligand-1 (PD-L1) during porcine circovirus type 2 (PCV2) infection and porcine circovirus associated diseases (PCVAD) development
These data suggest that overexpression of PD-L1 and PD-L2 (show PDCD1LG2 Proteins) mRNA is one mechanism by which immunosupression of postweaning multisystemic wasting syndrome pigs occurs.
Retinal PLD1 expression is enhanced in radial fibers of Muller cells with age. This finding suggests that PLD1 plays an important role in signal transduction of glial cells and neuronal cells in the retina.
A porcine PD-L1 molecule was cloned using RACE (rapid amplification of cDNA ends) technology and sequenced (GenBank # AY837780); it showed high sequence homology with human PD-L1.
This study provides novel information for the understanding of signalling through PD-L1.
Involved in the costimulatory signal essential for T- cell proliferation and IFNG production in a PDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation by blocking cell cycle progression and cytokine production.
, CD274 antigen
, programmed cell death 1 ligand 1
, programmed cell death ligand 1
, B7 homolog 1
, PDCD1 ligand 1
, programmed death ligand 1