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Involved in the costimulatory signal essential for T- cell proliferation and IFNG production in a PDCD1-independent manner. Additionally we are shipping PD-L1 Antibodies (344) and PD-L1 Kits (45) and many more products for this protein.
Showing 10 out of 79 products:
Dog (Canine) PD-L1 Protein expressed in Human Cells - ABIN2008991
Trabattoni, Saresella, Biasin, Boasso, Piacentini, Ferrante, Dong, Maserati, Shearer, Chen, Clerici: B7-H1 is up-regulated in HIV infection and is a novel surrogate marker of disease progression. in Blood 2003
Show all 4 references for 2008991
Rat (Rattus) PD-L1 Protein expressed in Human Cells - ABIN2009643
Dong, Zhu, Tamada, Chen: B7-H1, a third member of the B7 family, co-stimulates T-cell proliferation and interleukin-10 secretion. in Nature medicine 1999
Show all 4 references for 2009643
Mouse (Murine) PD-L1 Protein expressed in Human Cells - ABIN2007139
Dong, Strome, Salomao, Tamura, Hirano, Flies, Roche, Lu, Zhu, Tamada, Lennon, Celis, Chen: Tumor-associated B7-H1 promotes T-cell apoptosis: a potential mechanism of immune evasion. in Nature medicine 2002
Show all 4 references for 2007139
Rat (Rattus) PD-L1 Protein expressed in Human Cells - ABIN2009641
Tamura, Ogata, Dong, Chen: Immunology of B7-H1 and its roles in human diseases. in International journal of hematology 2003
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Mouse (Murine) PD-L1 Protein expressed in Escherichia coli (E. coli) - ABIN1098649
Li, Deng, He, Liu, Wang, Young, Meng, Du, Huang, Chen, Chen, Martin, Forman, Zeng: Loss of B7-H1 expression by recipient parenchymal cells leads to expansion of infiltrating donor CD8+ T cells and persistence of graft-versus-host disease. in Journal of immunology (Baltimore, Md. : 1950) 2012
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Cynomolgus PD-L1 Protein expressed in HEK-293 Cells - ABIN2181633
Freeman, Long, Iwai, Bourque, Chernova, Nishimura, Fitz, Malenkovich, Okazaki, Byrne, Horton, Fouser, Carter, Ling, Bowman, Carreno, Collins, Wood, Honjo: Engagement of the PD-1 immunoinhibitory receptor by a novel B7 family member leads to negative regulation of lymphocyte activation. in The Journal of experimental medicine 2000
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Cynomolgus PD-L1 Protein expressed in Human Cells - ABIN2010048
Holets, Hunt, Petroff: Trophoblast CD274 (B7-H1) is differentially expressed across gestation: influence of oxygen concentration. in Biology of reproduction 2006
These results indicate that the outcome of PD-L1-mediated signaling in CD8 (show CD8A Proteins)+ T cells depends on the presence or absence of CD4 (show CD4 Proteins)+ T cells, the nature of the interacting receptor expressed by CD8 (show CD8A Proteins)+ T cells, and the tissue environment in which the signaling occurs.
CD169 (show SIGLEC1 Proteins)(+) macrophages are important contributors to the IFN-I response and thereby influence antiviral activity, CD8 (show CD8A Proteins)(+) T-cell exhaustion and immunopathology.
findings identify a previously unrecognized role of PD-L1 as an endogenous pain inhibitor and a neuromodulator.
reduced cytotoxicity as a key mechanism by which tumor PD-L1 suppresses antitumor immunity and demonstrate that tumor PD-L1 is not just a marker of suppressed antitumor immunity.
Apigenin inhibits IFN-gamma-induced (show SAMHD1 Proteins) PD-L1 expression by breast cancer cells, potentially rendering BC cells that lack constitutive PD-L1 expression more susceptible to T cellmediated anti-tumor immune responses.
results reveal a novel CD40 (show CD40 Proteins)-dependent regulation of PD-L1 trafficking induced upon TLR3 (show TLR3 Proteins) signaling that dictates its inhibitory activity.
IL-6 (show IL6 Proteins) and PD-L1 blockade combination inhibits hepatocellular carcinoma cancer development in a mouse model.
PD-1 (show PDCD1 Proteins)/PD-L1 plays a crucial role in maintaining immune tolerance induced by UVB-iDCs, as well as in actively controlling effector T cells specific to alloantigens.
Data show that Qiyusanlong decoction (QYSL) can moderately inhibit the growth of the transplanted tumor by decreasing programmed death 1 (show PDCD1 Proteins) and programmed death ligand 1 (PD-1 (show PDCD1 Proteins)/PD-L1) level.
Expression of PD-L1 is correlated with the severity of periodontitis in the mouse model of experimental periodontitis.
In cutaneous diffuse large b-cell lymphoma, a considerable proportion of CD33 (show CD33 Proteins)(+) myeloid-derived suppressor cells (MDSCs) with PD-L1 coexpression was admixed. Tumor cells expressed CD33 (show CD33 Proteins) to variable degrees (2% to 60%). We propose that PD-L1(+) tumor cells and PD-L1(+) MDSCs shield the tumor against PD-1 (show PDCD1 Proteins)(+) tumor-infiltrating lymphocytes, consequently leading to inhibition and diminution of tumor-infiltrating lymphocytes.
Studied PD-L1 expression in melanoma subtypes.
PD-L1 expression was detected in the vast majority of tumor samples, while inflammatory cell compartments showed a higher degree of variation
PD-L1 was expressed on anaplastic thyroid cancer tumor cells in most samples and showed mainly membranous staining.
TGF-beta1 (show TGFB1 Proteins) induced EMT (show ITK Proteins) and surface expression of PD-L1 in TE5, TE6 and TE11 cell lines.
coronary artery disease macrophages respond to nutrient excess by activating the immunoinhibitory PD-1 (show PDCD1 Proteins)/PD-L1 checkpoint, leading to impaired T cell immunity.
High PD-L1 expression is associated with metastasis in esophageal adenocarcinomas.
PD-L1 expression status may be a new predictor of recurrence for stage III colorectal cancer patients.
For anti-CTLA4 (show CTLA4 Proteins) therapy, there were no data retrievable on clinical efficacy. Although data on clinical efficacy of checkpoint inhibitors in metastatic bladder cancer are currently limited, the efficacy of these drugs might depend mainly on the metastatic volume and immune system integrity. Patients with PD-L1 positive tumors and non-visceral metastases seem to derive the highest benefit from therapy.
Meta-analysis demonstrated that PD-L1 expression in TIICs might serve as a new biomarker for prognosticating the survival of cancer patients.
role of programmed death ligand-1 (PD-L1) during porcine circovirus type 2 (PCV2) infection and porcine circovirus associated diseases (PCVAD) development
These data suggest that overexpression of PD-L1 and PD-L2 (show PDCD1LG2 Proteins) mRNA is one mechanism by which immunosupression of postweaning multisystemic wasting syndrome pigs occurs.
Retinal PLD1 expression is enhanced in radial fibers of Muller cells with age. This finding suggests that PLD1 plays an important role in signal transduction of glial cells and neuronal cells in the retina.
A porcine PD-L1 molecule was cloned using RACE (rapid amplification of cDNA ends) technology and sequenced (GenBank # AY837780); it showed high sequence homology with human PD-L1.
This study provides novel information for the understanding of signalling through PD-L1.
Involved in the costimulatory signal essential for T- cell proliferation and IFNG production in a PDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation by blocking cell cycle progression and cytokine production.
, CD274 antigen
, programmed cell death 1 ligand 1
, programmed cell death ligand 1
, B7 homolog 1
, PDCD1 ligand 1
, programmed death ligand 1