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The protein encoded by CD276 belongs to the immunoglobulin superfamily, and thought to participate in the regulation of T-cell-mediated immune response. Additionally we are shipping CD276 Proteins (25) and CD276 Kits (11) and many more products for this protein.
Showing 10 out of 213 products:
Human Monoclonal CD276 Primary Antibody for FACS - ABIN2663289
Ford, McVicar: TREM and TREM-like receptors in inflammation and disease. in Current opinion in immunology 2009
Show all 8 references for ABIN2663289
Mouse (Murine) Monoclonal CD276 Primary Antibody for FACS - ABIN2663287
Sun, Richards, Prasad, Mai, Rudensky, Dong: Characterization of mouse and human B7-H3 genes. in Journal of immunology (Baltimore, Md. : 1950) 2002
Show all 3 references for ABIN2663287
Human Monoclonal CD276 Primary Antibody for FACS - ABIN317048
Sun, Vale, Leung, Kanwar, Gupta, Krissansen: Mouse B7-H3 induces antitumor immunity. in Gene therapy 2003
Show all 3 references for ABIN317048
Human Monoclonal CD276 Primary Antibody for FACS - ABIN317045
Chapoval, Ni, Lau, Wilcox, Flies, Liu, Dong, Sica, Zhu, Tamada, Chen: B7-H3: a costimulatory molecule for T cell activation and IFN-gamma production. in Nature immunology 2001
Show all 3 references for ABIN317045
Human Monoclonal CD276 Primary Antibody for FACS, IHC - ABIN969018
Gerhard, Wagner, Feingold, Shenmen, Grouse, Schuler, Klein, Old, Rasooly, Good, Guyer, Peck, Derge, Lipman, Collins, Jang, Sherry, Feolo, Misquitta, Lee, Rotmistrovsky, Greenhut, Schaefer, Buetow et al.: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). ... in Genome research 2004
Show all 2 references for ABIN969018
Human Monoclonal CD276 Primary Antibody for EIA, FACS - ABIN1106180
Zhang, Dong, Xu, Yu, Zhang: B7-H3: another molecule marker for Mo-DCs? in Cellular & molecular immunology 2005
Human Polyclonal CD276 Primary Antibody for IP, ELISA - ABIN1998403
Loos, Hedderich, Friess, Kleeff: B7-h3 and its role in antitumor immunity. in Clinical & developmental immunology 2010
Anterior pituitary gland progenitor cells containing 4Ig-B7-H3 (CD276) may play a critical role in the immunoendocrine network.
Data show that B7-H3 protein is over-expressed in cerulein-induced acute pancreatitis, and anti-B7-H3 monoclonal antibody can attenuate the inflammation and alleviate the injury of pancreas and lung tissues.
Ablation of B7-H3 but Not B7-H4 (show VTCN1 Antibodies) Results in Highly Increased Tumor Burden in a Murine Model of Spontaneous Prostate Cancer
Murine B7-H3 is a positive co-stimulatory molecule in the regulation of T cell-mediated immune responses.
B7-H3 inhibits T cell proliferation. FG loop of the IgV domain plays a critical role in this function. B7-H3 crystallized as an unusual dimer arising from the exchange of the G strands in the IgV domains of partner molecules
The study investigates the role of B7-H3 in pancreatic cancer progression and shows that this protein promotes cancer cell migration and invasiveness in vitro and in vivo.
Graft prolongation achieved by CTLA4 (show CTLA4 Antibodies) Ig was shortened both by B7-H3 blockade and the absence of recipient B7-H3.
Macrophage-tumor cell interaction-induced membrane-bound B7-H3 represents a novel immune escape mechanism which links the pro-inflammatory response to immune tolerance in the tumor milieu.
Exogenous administration of B7-H3 strongly amplifies the inflammatory response, exacerbates blood-brain barrier disruption, and aggravates the clinical disease status in Streptococcus pneumoniae-infected C3H/HeN (show RPS6 Antibodies) wild-type mice.
Tumour-associated B7-H3 directly augments CD8 (show CD8A Antibodies)(+) T-cell effector function, possibly by ligation of TLT-2 (show TREML2 Antibodies) on tumour-infiltrating CD8 (show CD8A Antibodies)(+) T cells at the local tumour site.
B7-H3 serves as a negative regulator of T cell activation and function
The results provide novel insights into the function of B7-H3 in cancer, and suggest that targeting of B7-H3 may be a novel alternative to improve current anticancer therapies.
Suggesting that B7-H3 and Tregs may act cooperatively in tumor immune evasion, leading to poor outcomes for NSCLC patients.
B7-H3 is one of the most strongly expressed B7-family molecules in AML (show RUNX1 Antibodies) and merits further investigation.
findings demonstrate that activation-induced B7-H3 expression on synovial monocytes has the potential to inhibit Th1 (show TH1L Antibodies)-mediated immune responses and immunomodulatory roles affecting RA pathogenesis.
B7H3 promotes cell migration and invasion through the Jak2 (show JAK2 Antibodies)/Stat3 (show STAT3 Antibodies)/MMP9 (show MMP9 Antibodies) signaling pathway in colorectal cancer
B7-H1 (show CD274 Antibodies) and B7-H3 are independent predictors of poorer survival in patients with non-small cell lung cancer.
B7-H3 may play an important role in asthma exacerbation and was a useful clinical biomarker to evaluate asthma exacerbation.
found that the N-glycans of B7-H3 from Ca9 (show CA9 Antibodies)-22 oral cancer cells contain the terminal alpha-galactose and are more diverse with higher fucosylation and better interaction with DC-SIGN (show CD209 Antibodies) and Langerin (show CD207 Antibodies) on immune cells than that from normal cells
Study shows that B7-H3 promotes mantle cell lymphoma progression and its knockdown significantly enhances the chemosensitivity.
These results demonstrated that B7-H3 expression in acute leukemia predicts an unfavorable outcome.
The protein encoded by this gene belongs to the immunoglobulin superfamily, and thought to participate in the regulation of T-cell-mediated immune response. Studies show that while the transcript of this gene is ubiquitously expressed in normal tissues and solid tumors, the protein is preferentially expressed only in tumor tissues. Additionally, it was observed that the 3' UTR of this transcript contains a target site for miR29 microRNA, and there is an inverse correlation between the expression of this protein and miR29 levels, suggesting regulation of expression of this gene product by miR29. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
, CD276 antigen-like
, CD276 antigen homolog
, CD276 antigen
, B7 homolog 3
, costimulatory molecule