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The protein encoded by CD276 belongs to the immunoglobulin superfamily, and thought to participate in the regulation of T-cell-mediated immune response. Additionally we are shipping CD276 Antibodies (214) and CD276 Proteins (25) and many more products for this protein.
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Anterior pituitary gland progenitor cells containing 4Ig-B7-H3 (CD276) may play a critical role in the immunoendocrine network.
Data show that B7-H3 protein is over-expressed in cerulein-induced acute pancreatitis, and anti-B7-H3 monoclonal antibody can attenuate the inflammation and alleviate the injury of pancreas and lung tissues.
Ablation of B7-H3 but Not B7-H4 (show VTCN1 ELISA Kits) Results in Highly Increased Tumor Burden in a Murine Model of Spontaneous Prostate Cancer
Murine B7-H3 is a positive co-stimulatory molecule in the regulation of T cell-mediated immune responses.
B7-H3 inhibits T cell proliferation. FG loop of the IgV domain plays a critical role in this function. B7-H3 crystallized as an unusual dimer arising from the exchange of the G strands in the IgV domains of partner molecules
The study investigates the role of B7-H3 in pancreatic cancer progression and shows that this protein promotes cancer cell migration and invasiveness in vitro and in vivo.
Graft prolongation achieved by CTLA4 (show CTLA4 ELISA Kits) Ig was shortened both by B7-H3 blockade and the absence of recipient B7-H3.
Macrophage-tumor cell interaction-induced membrane-bound B7-H3 represents a novel immune escape mechanism which links the pro-inflammatory response to immune tolerance in the tumor milieu.
Exogenous administration of B7-H3 strongly amplifies the inflammatory response, exacerbates blood-brain barrier disruption, and aggravates the clinical disease status in Streptococcus pneumoniae-infected C3H/HeN (show RPS6 ELISA Kits) wild-type mice.
Tumour-associated B7-H3 directly augments CD8 (show CD8A ELISA Kits)(+) T-cell effector function, possibly by ligation of TLT-2 (show TREML2 ELISA Kits) on tumour-infiltrating CD8 (show CD8A ELISA Kits)(+) T cells at the local tumour site.
B7-H3 serves as a negative regulator of T cell activation and function
B7-H3 and B7-H4 (show VTCN1 ELISA Kits) are involved in esophageal squamous cell carcinoma (ESCC) progression and development and their coexpression could be valuable prognostic indicators.
Upregulated sB7-H3 expression in MPEs is correlated with TNM (show ODZ1 ELISA Kits) stage of NSCLC and may serve as a potential biomarker for NSCLC-derived MPEs
High expression of B7-H3 is associated with Colorectal cancer.
Elevated B7-H3 expression is significantly associated with poor survival in cancer patients. (Meta-analysis)
The results provide novel insights into the function of B7-H3 in cancer, and suggest that targeting of B7-H3 may be a novel alternative to improve current anticancer therapies.
Suggesting that B7-H3 and Tregs may act cooperatively in tumor immune evasion, leading to poor outcomes for NSCLC patients.
B7-H3 is one of the most strongly expressed B7-family molecules in AML (show RUNX1 ELISA Kits) and merits further investigation.
findings demonstrate that activation-induced B7-H3 expression on synovial monocytes has the potential to inhibit Th1 (show TH1L ELISA Kits)-mediated immune responses and immunomodulatory roles affecting RA pathogenesis.
B7H3 promotes cell migration and invasion through the Jak2 (show JAK2 ELISA Kits)/Stat3 (show STAT3 ELISA Kits)/MMP9 (show MMP9 ELISA Kits) signaling pathway in colorectal cancer
B7-H1 (show CD274 ELISA Kits) and B7-H3 are independent predictors of poorer survival in patients with non-small cell lung cancer.
The protein encoded by this gene belongs to the immunoglobulin superfamily, and thought to participate in the regulation of T-cell-mediated immune response. Studies show that while the transcript of this gene is ubiquitously expressed in normal tissues and solid tumors, the protein is preferentially expressed only in tumor tissues. Additionally, it was observed that the 3' UTR of this transcript contains a target site for miR29 microRNA, and there is an inverse correlation between the expression of this protein and miR29 levels, suggesting regulation of expression of this gene product by miR29. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
, CD276 antigen-like
, CD276 antigen homolog
, CD276 antigen
, B7 homolog 3
, costimulatory molecule