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The protein encoded by CD276 belongs to the immunoglobulin superfamily, and thought to participate in the regulation of T-cell-mediated immune response. Additionally we are shipping CD276 Antibodies (218) and CD276 Kits (11) and many more products for this protein.
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Human CD276 Protein expressed in Human Cells - ABIN2004060
Suh, Gajewska, Okada, Gronski, Bertram, Dawicki, Duncan, Bukczynski, Plyte, Elia, Wakeham, Itie, Chung, Da Costa, Arya, Horan, Campbell, Gaida, Ohashi, Watts, Yoshinaga, Bray, Jordana, Mak: The B7 family member B7-H3 preferentially down-regulates T helper type 1-mediated immune responses. in Nature immunology 2003
Anterior pituitary gland progenitor cells containing 4Ig-B7-H3 (CD276) may play a critical role in the immunoendocrine network.
Data show that B7-H3 protein is over-expressed in cerulein-induced acute pancreatitis, and anti-B7-H3 monoclonal antibody can attenuate the inflammation and alleviate the injury of pancreas and lung tissues.
Ablation of B7-H3 but Not B7-H4 (show VTCN1 Proteins) Results in Highly Increased Tumor Burden in a Murine Model of Spontaneous Prostate Cancer
Murine B7-H3 is a positive co-stimulatory molecule in the regulation of T cell-mediated immune responses.
B7-H3 inhibits T cell proliferation. FG loop of the IgV domain plays a critical role in this function. B7-H3 crystallized as an unusual dimer arising from the exchange of the G strands in the IgV domains of partner molecules
The study investigates the role of B7-H3 in pancreatic cancer progression and shows that this protein promotes cancer cell migration and invasiveness in vitro and in vivo.
Graft prolongation achieved by CTLA4 (show CTLA4 Proteins) Ig was shortened both by B7-H3 blockade and the absence of recipient B7-H3.
Macrophage-tumor cell interaction-induced membrane-bound B7-H3 represents a novel immune escape mechanism which links the pro-inflammatory response to immune tolerance in the tumor milieu.
Exogenous administration of B7-H3 strongly amplifies the inflammatory response, exacerbates blood-brain barrier disruption, and aggravates the clinical disease status in Streptococcus pneumoniae-infected C3H/HeN (show RPS6 Proteins) wild-type mice.
Tumour-associated B7-H3 directly augments CD8 (show CD8A Proteins)(+) T-cell effector function, possibly by ligation of TLT-2 (show TREML2 Proteins) on tumour-infiltrating CD8 (show CD8A Proteins)(+) T cells at the local tumour site.
B7-H3 serves as a negative regulator of T cell activation and function
Elevated B7-H3 expression is significantly associated with poor survival in cancer patients. (Meta-analysis)
The results provide novel insights into the function of B7-H3 in cancer, and suggest that targeting of B7-H3 may be a novel alternative to improve current anticancer therapies.
Suggesting that B7-H3 and Tregs may act cooperatively in tumor immune evasion, leading to poor outcomes for NSCLC patients.
B7-H3 is one of the most strongly expressed B7-family molecules in AML (show RUNX1 Proteins) and merits further investigation.
findings demonstrate that activation-induced B7-H3 expression on synovial monocytes has the potential to inhibit Th1 (show TH1L Proteins)-mediated immune responses and immunomodulatory roles affecting RA pathogenesis.
B7H3 promotes cell migration and invasion through the Jak2 (show JAK2 Proteins)/Stat3 (show STAT3 Proteins)/MMP9 (show MMP9 Proteins) signaling pathway in colorectal cancer
B7-H1 (show CD274 Proteins) and B7-H3 are independent predictors of poorer survival in patients with non-small cell lung cancer.
B7-H3 may play an important role in asthma exacerbation and was a useful clinical biomarker to evaluate asthma exacerbation.
found that the N-glycans of B7-H3 from Ca9 (show CA9 Proteins)-22 oral cancer cells contain the terminal alpha-galactose and are more diverse with higher fucosylation and better interaction with DC-SIGN (show CD209 Proteins) and Langerin (show CD207 Proteins) on immune cells than that from normal cells
Study shows that B7-H3 promotes mantle cell lymphoma progression and its knockdown significantly enhances the chemosensitivity.
The protein encoded by this gene belongs to the immunoglobulin superfamily, and thought to participate in the regulation of T-cell-mediated immune response. Studies show that while the transcript of this gene is ubiquitously expressed in normal tissues and solid tumors, the protein is preferentially expressed only in tumor tissues. Additionally, it was observed that the 3' UTR of this transcript contains a target site for miR29 microRNA, and there is an inverse correlation between the expression of this protein and miR29 levels, suggesting regulation of expression of this gene product by miR29. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
, CD276 antigen-like
, CD276 antigen homolog
, CD276 antigen
, B7 homolog 3
, costimulatory molecule