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Cd2ap encodes a scaffolding molecule that regulates the actin cytoskeleton. Additionally we are shipping CD2-Associated Protein Antibodies (46) and CD2-Associated Protein Kits (3) and many more products for this protein.
Showing 7 out of 7 products:
Tank1 (show TNKS Proteins)/Tank2 (show TNKS2 Proteins) inhibition aggravates kidney injury in the absence of CD2AP.
data suggest that CD2AP acts as a negative regulator of ICAM-1 (show ICAM1 Proteins) clustering, which limits the formation of ICAM-1 (show ICAM1 Proteins) adhesion complexes to prevent uncontrolled neutrophil adhesion and transcellular transmigration.
CD2AP expression in renal tubules may histologically associate with tissue hypoxia and reflected recovery from CsA-mediated renal injury in nephrotic syndrome patients.
data thus reveal a Golgi-traversing pathway for exosomal release of the cargo protein GPRC5B (show GPRC5B Proteins) in which CD2AP facilitates the entry and LMAN2 (show LMAN2 Proteins) impedes the exit of the flux, respectively.
Silencing Cindr in nephrocytes led to dramatic nephrocyte functional impairment and shortened life span, as well as collapse of nephrocyte lacunar channels and effacement of nephrocyte slit diaphragms. These phenotypes could be rescued by expression of a wild-type human CD2AP gene, but not a mutant allele derived from a patient with CD2AP-associated NS.
Study found a novel association of CD2AP with plasma homocysteine in participants with African ancestry and found a new variant in the candidate gene CBS (show CBS Proteins) associated with homocysteine
CD2AP rs9349407 polymorphism contributes to Alzheimer's disease susceptibility.
discovered novel interaction candidates for CD2AP and characterized subtle yet significant differences in the recognition preferences of its three SH3 domains for c-CBL (show CBL Proteins), ALIX (show PDCD6IP Proteins), and RIN3 (show RIN3 Proteins)
we present the first demonstration that the purified SH3 domains of the CD2AP/Cin85 (show SH3KBP1 Proteins) protein family are able to directly bind the p53 (show TP53 Proteins) protein, and to discriminate between the two polymorphic variants P72R
CD2-Associated Protein affects Abeta (show APP Proteins) levels and Abeta42/Abeta40 ratio in vitro
CD2AP gene variants may contribute to susceptibility to end-stage renal disease in patients with type 1 diabetes.
Bin1 (show BIN1 Proteins) and CD2AP keep APP (show APP Proteins) and BACE1 (show BACE Proteins) apart in early endosomes by distinct mechanisms in axon and dendrites. Individuals carrying variants of either factor would slowly accumulate Abeta (show APP Proteins) in neurons increasing the risk for late-onset AD.
CD2AP forms a complex with GGA2 (show GGA2 Proteins), a clathrin adaptor, which sorts Glut4 (show SLC2A4 Proteins) to GSVs, suggesting a role for CD2AP in this process.
CD2AP is the first signaling molecule associated with adult sensory axonal collateral sprouting
CD2AP has role in mediating blood-brain barrier integrity and cerebrovascular roles of CD2AP could contribute to its effects on Alzheimer's disease risk.
only the SH3 domains of CD2AP are necessary to enhance the E3 ligase activity of Cbl-3 (show CBLC Proteins)/c toward Ret51 (show RET Proteins)
CD2AP is not involved in the regulation of type I IFNs in plasmacytoid dendritic cells. Its major function is on the actin cytoskeleton, affecting migration to local lymph nodes under conditions of inflammation.
CD2AP deficiency results in the excretion of intact albumin (show ALB Proteins) in knockout mice.
the formation of lamellipodia is mediated by a complex of cortactin (show CTTN Proteins), CD2AP, and actin capping protein (show TMOD4 Proteins)
This gene encodes a scaffolding molecule that regulates the actin cytoskeleton. The protein directly interacts with filamentous actin and a variety of cell membrane proteins through multiple actin binding sites, SH3 domains, and a proline-rich region containing binding sites for SH3 domains. The cytoplasmic protein localizes to membrane ruffles, lipid rafts, and the leading edges of cells. It is implicated in dynamic actin remodeling and membrane trafficking that occurs during receptor endocytosis and cytokinesis. Haploinsufficiency of this gene is implicated in susceptibility to glomerular disease.
, Cas ligand with multiple Src homology 3 (SH3) domains
, adapter protein CMS
, cas ligand with multiple SH3 domains
, hypothetical protein
, SH3 domain-containing adapter protein
, SH3 domain-containing adaptor protein METS-1
, mesenchyme to epithelium transition protein, SH3 domains
, mesenchyme-to-epithelium transition protein with SH3 domains 1