Use your antibodies-online credentials, if available.
No Products on your Comparison List.
Your basket is empty.
Find out more
The CD3 complex mediates signal transduction.. Additionally we are shipping CD3 Antigen, epsilon Polypeptide Antibodies (2) and many more products for this protein.
Showing 3 out of 5 products:
The data show that CD3epsilon chain couples to Cbl via simultaneous binding of both proteins to Numb, thus mediating TCR degradation
IL-17 (show IL17A Proteins)-producing CD3(bright) gammadelta T cells responded promptly and strongly to pneumococcal infection and during skin inflammation.
these results suggest that CD3zeta can be degraded by two pathways: SLAP/c-Cbl, which targets internalized cell surface CD3zeta dependent on TCR signaling, and LAPTM5, which targets intracellular CD3zeta independent of TCR signaling.
these results indicate that membrane association of the CD3epsilon signaling domain is required for optimal thymocyte development and peripheral T cell function.
These results suggest that proteasome-mediated degradation is involved in hypophosphorylated LAT (show LAT Proteins) and PLCgamma1 (show PLCG1 Proteins) in Dow2-induced anergic T cells. The novel CD3-specific Ab, Dow2, may provide us with a unique tool for inducing immunosuppression
that Nck (show NCK1 Proteins) recruitment to the TCR is fundamental to mount an efficient T cell response in vivo, and that the Nck (show NCK1 Proteins)-CD3epsilon interaction may represent a target for pharmacological modulation of the immune response.
Structure of murine CD3epsilon complexed with the mitogenic anti-CD3epsilon antibody 2C11 enabled structural comparisons of antibody-liganded and unliganded forms of CD3epsilon revealing that antibody binding does not induce any substantial rearrangements within CD3epsilon.
CFTR (show CFTR Proteins) dysfunction in T cells can lead directly to aberrant immune responses in CD3+ lymphocytes
analysis of the transgenic integration site in immunodeficient tgepsilon26 human CD3epsilon transgenic mice
Polymorphisms of the CD3varepsilon ectodomain exist in mice,some of which lead to amino acid substitutions which cause structural changes and affect anti-CD3 antibody binding.
The CD3 complex mediates signal transduction.
T-cell surface antigen T3/Leu-4 epsilon chain
, T-cell surface glycoprotein CD3 epsilon chain