CD3 Antigen, epsilon Polypeptide Proteins (CD3E)

The CD3 complex mediates signal transduction.. Additionally we are shipping and many more products for this protein.

list all proteins Gene Name GeneID UniProt
Mouse CD3E CD3E 12501 P22646
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More Proteins for CD3 Antigen, epsilon Polypeptide (CD3E) Interaction Partners

Mouse (Murine) CD3 Antigen, epsilon Polypeptide (CD3E) interaction partners

  1. The data show that CD3epsilon chain couples to Cbl via simultaneous binding of both proteins to Numb, thus mediating TCR degradation

  2. IL-17 (show IL17A Proteins)-producing CD3(bright) gammadelta T cells responded promptly and strongly to pneumococcal infection and during skin inflammation.

  3. these results suggest that CD3zeta can be degraded by two pathways: SLAP/c-Cbl, which targets internalized cell surface CD3zeta dependent on TCR signaling, and LAPTM5, which targets intracellular CD3zeta independent of TCR signaling.

  4. these results indicate that membrane association of the CD3epsilon signaling domain is required for optimal thymocyte development and peripheral T cell function.

  5. These results suggest that proteasome-mediated degradation is involved in hypophosphorylated LAT (show LAT Proteins) and PLCgamma1 (show PLCG1 Proteins) in Dow2-induced anergic T cells. The novel CD3-specific Ab, Dow2, may provide us with a unique tool for inducing immunosuppression

  6. that Nck (show NCK1 Proteins) recruitment to the TCR is fundamental to mount an efficient T cell response in vivo, and that the Nck (show NCK1 Proteins)-CD3epsilon interaction may represent a target for pharmacological modulation of the immune response.

  7. Structure of murine CD3epsilon complexed with the mitogenic anti-CD3epsilon antibody 2C11 enabled structural comparisons of antibody-liganded and unliganded forms of CD3epsilon revealing that antibody binding does not induce any substantial rearrangements within CD3epsilon.

  8. CFTR (show CFTR Proteins) dysfunction in T cells can lead directly to aberrant immune responses in CD3+ lymphocytes

  9. analysis of the transgenic integration site in immunodeficient tgepsilon26 human CD3epsilon transgenic mice

  10. Polymorphisms of the CD3varepsilon ectodomain exist in mice,some of which lead to amino acid substitutions which cause structural changes and affect anti-CD3 antibody binding.

CD3 Antigen, epsilon Polypeptide (CD3E) Protein Profile

Protein Summary

The CD3 complex mediates signal transduction.

Gene names and symbols associated with CD3E

  • CD3 antigen, epsilon polypeptide (Cd3e)
  • AI504783 protein
  • CD3 protein
  • CD3epsilon protein
  • T3e protein

Protein level used designations for CD3E

T-cell surface antigen T3/Leu-4 epsilon chain , T-cell surface glycoprotein CD3 epsilon chain

12501 Mus musculus
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