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CD320 encodes the transcobalamin receptor that is expressed at the cell surface. Additionally we are shipping CD320 Proteins (20) and CD320 Kits (6) and many more products for this protein.
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Severe cobalamin depletion in the central nervous system (CNS) after birth in TCblR knockouts indicates that TCblR is the only receptor responsible for cobalamin uptake in the CNS
In vivo, endogenous PCSK9 (show PCSK9 Antibodies) regulates VLDLR (show VLDLR Antibodies) protein levels and triglyceride accumulation in adipose tissue.
Diabetic rats showed severe hyperlipidemia on d 21 and 28, with a dramatic decline in VLDL-R (show VLDLR Antibodies) protein in skeletal muscle (>90%), heart (approximately 50%) and a loss of adipose tissues itself.
Reelin (show RELN Antibodies) binds several receptors, including the VLDL receptor (show VLDLR Antibodies) in cultured hippocampus neurons.
VLDL and LDL lowering by gene transfer of the VLDL receptor (show VLDLR Antibodies) combined with a low-fat diet regimen induces regression and reduces macrophage content in advanced atherosclerotic lesions in LDL receptor (show LDLR Antibodies)-deficient mice
These data demonstrate a cell-autonomous function of ApoER2 (show LRP8 Antibodies), and most likely VLDLR (show VLDLR Antibodies) and Dab1 (show DAB1 Antibodies), in postnatal migration of neuroblasts in the forebrain, which is suggested to depend on ligands other than Reelin (show RELN Antibodies).
The high affinity of apoE4 to the LDLR (show LDLR Antibodies) enhances VLDL sequestration on the hepatocyte surface but delays their internalization.
Data show that thrombospondin-1 (THBS-1 (show THBS1 Antibodies)) is a novel physiological ligand for ApoER2 (show LRP8 Antibodies) and VLDLR (show VLDLR Antibodies), and that lack of THBS-1 (show THBS1 Antibodies) results in anatomical abnormalities of the RMS and leads to a reduction of postnatal neuronal precursors entering the OB.
Although not significant when corrected for multiple testing, eight single nucleotide polymorphisms (SNPs) in two genes, transcobalamin II (TCN2 (show TCN2 Antibodies)) and the transcobalamin II (show TCN2 Antibodies)-receptor (TCblR), were found to influence several clinical traits of cobalamin deficiency.
The soluble transcobalamin receptor is present in cerebrospinal fluid and correlates to dementia-related biomarkers tau proteins and amyloid-beta.
Transcobalamin II (TCN2 (show TCN2 Antibodies) 67A>G and TCN2 (show TCN2 Antibodies) 776C>G) and transcobalamin II (show TCN2 Antibodies) receptor (TCblR 1104C>T) polymorphisms in Korean patients with idiopathic recurrent spontaneous abortion
Data indicate that only the extracellular region (aa 32-229) of TCblR/CD320 is needed for transcobalamin-cobalamin (TC-Cbl (show CBL Antibodies)) binding.
Proliferating cancer cells express measurable levels of TCII (show TCN2 Antibodies) and TCII (show TCN2 Antibodies)-R.
TCblr SNP were associated with omphalocele suggests that disruption of methylation reactions, in which folate, vitamin B12 (show NDUFB3 Antibodies), and homocysteine play critical parts, may be a risk factor for omphalocele.
Our data suggest that variation in TCblR plays a role in neural tube defect risk and that these variants may modulate cobalamin metabolism.
the cell cycle associated expression of TCblR appears to be tightly regulated in synchrony with the proliferative phase of the cell cycle.
Analysis of TCblR/CD320, the gene for the receptor for cellular uptake of transcobalamin-bound cobalamin, identified a homozygous single codon deletion, c.262_264GAG (p.E88del), resulting in the loss of a glutamic acid residue.
Confocal microscopy of tonsil sections revealed co-localization of CD320 with CD19 (show CD19 Antibodies) and CD38 but not with CD3 (show CD3 Antibodies) indicating that germinal center B cells expressed CD320 in addition to follicular dendritic cells.
This gene encodes the transcobalamin receptor that is expressed at the cell surface. It mediates the cellular uptake of transcobalamin bound cobalamin (vitamin B12), and is involved in B-cell proliferation and immunoglobulin secretion. Mutations in this gene are associated with methylmalonic aciduria. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
, putative VLDL lipoprotein receptor
, transcobalamin receptor
, 8D6 antigen
, CD320 antigen
, FDC-signaling molecule 8D6