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Putative adhesion molecule of myelomonocytic-derived cells that mediates sialic-acid dependent binding to cells. Additionally we are shipping CD33 Antibodies (612) and CD33 Proteins (30) and many more products for this protein.
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Lectin galactoside-binding soluble 3 binding protein (LGALS3BP (show LGALS3BP ELISA Kits)) is a tumor-associated immunomodulatory ligand for CD33-related Siglecs.
CD33-related Siglec-E recognizes the intact neuron and has neuroprotective function by preventing phagocytosis.
SOCS3 (show SOCS3 ELISA Kits) inhibited the CD33-induced block on cytokine-induced proliferation. SOCS3 (show SOCS3 ELISA Kits) and its target protein CD33 are degraded concomitantly concomitantly.
CD33-expressing microglia play a central role in the development of leukoencephalopathy in Nasu-Hakola disease brains
There is substantial evidence that rs3865444 (CD33) function is related to AD pathways and pathology, but our data does not support an interaction with rs670139 (MS4A4E) that impacts AD risk.
this study investigated the contribution of the immunoregulatory receptor CD33 to a uniquely human postreproductive disease, Alzheimer's dementia.
the CD33 rs3865444 polymorphism is associated with Alzheimer's disease susceptibility in Chinese, European, and North American populations.
CD33 and MS4A cluster variants are associated with LOAD susceptibility in East Asian populations.
Among those with one or more APOE (show APOE ELISA Kits) epsilon4 alleles, having one or more copies of the CD33 C (risk) allele may further increase the risk of cognitive decline
decreased TREM2 (show TREM2 ELISA Kits) expression with CD33 suppression and elevated cortical TREM2 (show TREM2 ELISA Kits) mRNA expression with amyloid pathology
we propose a model wherein a modest effect on RNA splicing is sufficient to mediate the CD33 association with AD risk and suggest the potential for an anti-CD33 antibody as an AD-relevant pharmacologic agent.
Studies indicate that anti-CD19 (show CD19 ELISA Kits) and anti-CD33 bispecific antibodies showed anticancer activity.
Its single-nucleotide polymorphism rs3865444 in the CD33 gene as being associated with the reduced risk of developing Alzheimer's disease.
Putative adhesion molecule of myelomonocytic-derived cells that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. Induces apoptosis in acute myeloid leukemia (in vitro).
CD33 antigen (gp67)
, myeloid cell surface antigen CD33
, sialic acid-binding Ig-like lectin 3
, sialic acid binding Ig-like lectin 3