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Putative adhesion molecule of myelomonocytic-derived cells that mediates sialic-acid dependent binding to cells. Additionally we are shipping CD33 Kits (35) and CD33 Proteins (32) and many more products for this protein.
Showing 10 out of 622 products:
Human Polyclonal CD33 Primary Antibody for EIA, IHC (p) - ABIN357141
Yousef, Ordon, Foussias, Diamandis: Genomic organization of the siglec gene locus on chromosome 19q13.4 and cloning of two new siglec pseudogenes. in Gene 2002
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Human Polyclonal CD33 Primary Antibody for FACS, IF (p) - ABIN676958
Shi, Jiang, Li, Shan, Li, An, Yang, Xu: Sodium selenite alters microtubule assembly and induces apoptosis in vitro and in vivo. in Journal of hematology & oncology 2013
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Human Monoclonal CD33 Primary Antibody for FACS, IP - ABIN319734
Favaloro, Bradstock, Kabral, Grimsley, Zowtyj, Zola et al.: Further characterization of human myeloid antigens (gp160,95; gp150; gp67): investigation of epitopic heterogeneity and non-haemopoietic distribution using panels of monoclonal antibodies belonging ... in British journal of haematology 1988
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Human Monoclonal CD33 Primary Antibody for FACS, IHC - ABIN1724813
Schubert, Kellner, Stein, Kügler, Schwenkert, Saul, Mentz, Singer, Stockmeyer, Hillen, Mackensen, Fey: A single-chain triplebody with specificity for CD19 and CD33 mediates effective lysis of mixed lineage leukemia cells by dual targeting. in mAbs 2011
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Mouse (Murine) Polyclonal CD33 Primary Antibody for FACS, IF (p) - ABIN687607
Shan, Bu, Zhang, Zhang, Ding, Chang, Dai, Shen, Ma: LukS-PV, a component of Panton-Valentine leukocidin, exerts potent activity against acute myeloid leukemia in vitro and in vivo. in The international journal of biochemistry & cell biology 2015
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Human Monoclonal CD33 Primary Antibody for FACS - ABIN118633
Favaloro, Bradstock, Kabral, Grimsley, Berndt: Characterization of monoclonal antibodies to the human myeloid-differentiation antigen, 'gp67' (CD-33). in Disease markers 1988
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Human Monoclonal CD33 Primary Antibody for FACS, IHC (fro) - ABIN111914
Peiper, Ashmun, Look: Molecular cloning, expression, and chromosomal localization of a human gene encoding the CD33 myeloid differentiation antigen. in Blood 1988
Lectin galactoside-binding soluble 3 binding protein (LGALS3BP (show LGALS3BP Antibodies)) is a tumor-associated immunomodulatory ligand for CD33-related Siglecs.
CD33-related Siglec-E recognizes the intact neuron and has neuroprotective function by preventing phagocytosis.
SOCS3 (show SOCS3 Antibodies) inhibited the CD33-induced block on cytokine-induced proliferation. SOCS3 (show SOCS3 Antibodies) and its target protein CD33 are degraded concomitantly concomitantly.
Data suggest that two SNPs in CD33 (rs3865444A, rs12459419T) that are protective of Alzheimer disease result in splice variants (CD33M, CD33m); CD33M localizes predominantly at cell surface in macrophage cell line; CD33m is primary intracellular form in neutrophils and a microglia cell line; intracellular CD33m accumulates in peroxisomes; activation of macrophages/neutrophils does not mobilize CD33m to cell surface.
In cutaneous diffuse large b-cell lymphoma, a considerable proportion of CD33(+) myeloid-derived suppressor cells (MDSCs) with PD-L1 (show CD274 Antibodies) coexpression was admixed. Tumor cells expressed CD33 to variable degrees (2% to 60%). We propose that PD-L1 (show CD274 Antibodies)(+) tumor cells and PD-L1 (show CD274 Antibodies)(+) MDSCs shield the tumor against PD-1 (show PDCD1 Antibodies)(+) tumor-infiltrating lymphocytes, consequently leading to inhibition and diminution of tumor-infiltrating lymphocytes.
CD33-expressing microglia play a central role in the development of leukoencephalopathy in Nasu-Hakola disease brains
There is substantial evidence that rs3865444 (CD33) function is related to AD pathways and pathology, but our data does not support an interaction with rs670139 (MS4A4E) that impacts AD risk.
this study investigated the contribution of the immunoregulatory receptor CD33 to a uniquely human postreproductive disease, Alzheimer's dementia.
the CD33 rs3865444 polymorphism is associated with Alzheimer's disease susceptibility in Chinese, European, and North American populations.
CD33 and MS4A cluster variants are associated with LOAD susceptibility in East Asian populations.
Among those with one or more APOE (show APOE Antibodies) epsilon4 alleles, having one or more copies of the CD33 C (risk) allele may further increase the risk of cognitive decline
decreased TREM2 (show TREM2 Antibodies) expression with CD33 suppression and elevated cortical TREM2 (show TREM2 Antibodies) mRNA expression with amyloid pathology
we propose a model wherein a modest effect on RNA splicing is sufficient to mediate the CD33 association with AD risk and suggest the potential for an anti-CD33 antibody as an AD-relevant pharmacologic agent.
Putative adhesion molecule of myelomonocytic-derived cells that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. Induces apoptosis in acute myeloid leukemia (in vitro).
CD33 antigen (gp67)
, myeloid cell surface antigen CD33
, sialic acid-binding Ig-like lectin 3
, sialic acid binding Ig-like lectin 3