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CD46 Molecule, Complement Regulatory Protein Proteins (CD46)

The protein encoded by CD46 is a type I membrane protein and is a regulatory part of the complement system. Additionally we are shipping CD46 Molecule, Complement Regulatory Protein Antibodies (354) and CD46 Molecule, Complement Regulatory Protein Kits (20) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
CD46 822 P40121
CD46 17221 O88174
CD46 29333 Q9Z0M4
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Top CD46 Molecule, Complement Regulatory Protein Proteins at antibodies-online.com

Showing 10 out of 28 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_HEK-293 Cells Human His tag 50 μg Log in to see 21 to 31 Days
$346.50
Details
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 7 to 8 Days
$319.00
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 49 to 54 Days
$6,041.49
Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 49 to 54 Days
$4,244.78
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag 50 μg Log in to see 21 to 26 Days
$341.00
Details
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 11 to 13 Days
$756.80
Details
HOST_Escherichia coli (E. coli) Mouse His tag,GST tag 100 μg Log in to see 11 to 13 Days
$774.40
Details
HOST_Escherichia coli (E. coli) Rat His tag,GST tag 100 μg Log in to see 11 to 13 Days
$816.20
Details

CD46 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , , , , , ,
, ,
Mouse (Murine) ,
, ,
Rat (Rattus)

Top referenced CD46 Molecule, Complement Regulatory Protein Proteins

  1. Human CD46 Protein expressed in HEK-293 Cells - ABIN2180802 : Noris, Brioschi, Caprioli, Todeschini, Bresin, Porrati, Gamba, Remuzzi: Familial haemolytic uraemic syndrome and an MCP mutation. in Lancet 2003 (PubMed)
    Show all 5 references for ABIN2180802

  2. Human CD46 Protein expressed in Escherichia coli (E. coli) - ABIN1098582 : Riley, Kemper, Leung, Atkinson: Characterization of human membrane cofactor protein (MCP; CD46) on spermatozoa. in Molecular reproduction and development 2002 (PubMed)
    Show all 2 references for ABIN1098582

More Proteins for CD46 Molecule, Complement Regulatory Protein (CD46) Interaction Partners

Human CD46 Molecule, Complement Regulatory Protein (CD46) interaction partners

  1. On the basis of these results, we propose a model in which dynamic vimentin filaments target CARMIL2 to critical membrane-associated locations, where CARMIL2 regulates CP, and thus actin assembly, to create cell protrusions

  2. CD46 controls both Th1 (show TH1L Proteins) activation and regulation via a miR (show MLXIP Proteins)-150-dependent mechanism.

  3. The composite biomarker, CAPG and GIPC1 (show GIPC1 Proteins) in primary breast tumors, predicted disease outcomes and benefit from zoledronate and may facilitate patient selection for adjuvant bisphosphonate treatment.

  4. Data show that CD28 antigen (show CD28 Proteins) costimulation modulates CD46 antigen surface expression on activated T cells.

  5. This review summarizes our current knowledge of disease-associated mutations in this complement inhibitor(CD46).

  6. It was not discover any association between A304V or other CD46 SNPs and preeclampsia.

  7. gene deficiency results in defective Th1 (show TH1L Proteins) cell induction due to failure in metabolic reprogramming

  8. Each mutant C3b bound MCP at reduced affinity, providing a molecular basis for its reduced cofactor activity in atypical hemolytic uremic syndrome.

  9. The mutations in the regulators CFH (show CFH Proteins), CFI (show CFI Proteins) and MCP involve loss-of-function, whereas those for C3 involve gain-of-function.

  10. Results suggest a possible role for multidrug resistance genes ABCA10 and ABCA6 (show ABCA6 Proteins) in follicular lymphoma survival and add to the evidence that genetic variation in CD46 and IL8 (show IL8 Proteins) may have prognostic implications follicular lymphoma.

Mouse (Murine) CD46 Molecule, Complement Regulatory Protein (CD46) interaction partners

  1. Changes in CD46 expression may lead to changes in VEGF and play a pathologic role in the development of age-related macular degeneration.

  2. Our findings provide evidence for expression of CD46 in the mouse eye and a role for CD46 in protection against laser-induced choroidal neovascularization

  3. This fusion is mediated by the interaction between viral glycoproteins expressed on the membrane of the infected cells and CD46 on the glial targets, and is also observed using cells expressing recombinant MV glycoproteins.

  4. CD46 isoforms function as receptors for human herpesvirus 6 and measles virus

  5. Disruption of mouse CD46 causes an accelerated spontaneous acrosome reaction in sperm and increased male fertility

  6. CD46 has a role as a receptor for fusion and entry of human herpesvirus 6 into target cells

Cow (Bovine) CD46 Molecule, Complement Regulatory Protein (CD46) interaction partners

  1. Study shows the existence of 10 distinct allelic versions of the CCP1 (show AGTPBP1 Proteins) module of CD46; ectopic expression of the 10 bovine CD46 isoforms rendered the PK15 cells permissive to bovine viral diarrhea virus.

  2. localization of CD46 on bovine sperm membrane

Pig (Porcine) CD46 Molecule, Complement Regulatory Protein (CD46) interaction partners

  1. The results obtained in this study showed that both porcine CD46 and heparan sulfates play a major role in the initial steps of classical swine fever virus infection.

CD46 Molecule, Complement Regulatory Protein (CD46) Protein Profile

Protein Summary

The protein encoded by this gene is a type I membrane protein and is a regulatory part of the complement system. The encoded protein has cofactor activity for inactivation of complement components C3b and C4b by serum factor I, which protects the host cell from damage by complement. In addition, the encoded protein can act as a receptor for the Edmonston strain of measles virus, human herpesvirus-6, and type IV pili of pathogenic Neisseria. Finally, the protein encoded by this gene may be involved in the fusion of the spermatozoa with the oocyte during fertilization. Mutations at this locus have been associated with susceptibility to hemolytic uremic syndrome. Alternatively spliced transcript variants encoding different isoforms have been described.

Gene names and symbols associated with CD46

  • capping protein (actin filament), gelsolin-like (CAPG)
  • CD46 antigen, complement regulatory protein (Cd46)
  • CD46 molecule, complement regulatory protein (CD46)
  • CD46 molecule, complement regulatory protein (Cd46)
  • Membrane cofactor protein-like (LOC100341359)
  • AFCP protein
  • AHUS2 protein
  • Mcp protein
  • MIC10 protein
  • TLX protein
  • TRA2.10 protein

Protein level used designations for CD46

actin regulatory protein CAP-G , actin-regulatory protein CAP-G , gelsolin-like capping protein , macrophage capping protein , macrophage-capping protein , membrane cofactor protein , membrane cofactor protein(GMP1-full) , CD46 antigen, complement regulatory protein , antigen identified by monoclonal antibody TRA-2-10 , complement membrane cofactor protein , measles virus receptor , membrane cofactor protein (CD46, trophoblast-lymphocyte cross-reactive antigen) , trophoblast leucocyte common antigen , trophoblast leukocyte common antigen , trophoblast-lymphocyte cross-reactive antigen , brain microvascular membrane cofactor

GENE ID SPECIES
822 Homo sapiens
17221 Mus musculus
100135498 Cavia porcellus
4179 Homo sapiens
616002 Bos taurus
280851 Bos taurus
396922 Sus scrofa
29333 Rattus norvegicus
100341359 Oryctolagus cuniculus
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