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CD48 encodes a member of the CD2 subfamily of immunoglobulin-like receptors which includes SLAM (signaling lymphocyte activation molecules) proteins. Additionally we are shipping CD48 Antibodies (283) and CD48 Kits (8) and many more products for this protein.
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Human CD48 Protein expressed in Human Cells - ABIN2003398
Wong, Williams, Kingsmore, Seldin et al.: Structure, expression, and genetic linkage of the mouse BCM1 (OX45 or Blast-1) antigen. Evidence for genetic duplication giving rise to the BCM1 region on mouse chromosome 1 and the CD2/LFA3 region ... in The Journal of experimental medicine 1990
Show all 5 references for ABIN2003398
Rat (Rattus) CD48 Protein expressed in Human Cells - ABIN2009434
Ianelli, Edson, Thorley-Lawson: A ligand for human CD48 on epithelial cells. in Journal of immunology (Baltimore, Md. : 1950) 1997
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Mouse (Murine) CD48 Protein expressed in Human Cells - ABIN2007772
Ianelli, DeLellis, Thorley-Lawson: CD48 binds to heparan sulfate on the surface of epithelial cells. in The Journal of biological chemistry 1998
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Human CD48 Protein expressed in Human Cells - ABIN2003400
Loertscher, Lavery: The role of glycosyl phosphatidyl inositol (GPI)-anchored cell surface proteins in T-cell activation. in Transplant immunology 2002
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Mouse (Murine) CD48 Protein expressed in Human Cells - ABIN2007774
Assarsson, Kambayashi, Persson, Chambers, Ljunggren: 2B4/CD48-mediated regulation of lymphocyte activation and function. in Journal of immunology (Baltimore, Md. : 1950) 2005
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Human CD48 Protein expressed in HEK-293 Cells - ABIN2180807
Korínek, Stefanová, Angelisová, Hilgert, Horejsí: The human leucocyte antigen CD48 (MEM-102) is closely related to the activation marker Blast-1. in Immunogenetics 1991
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Molecular dynamic simulation explains unbinding and unfolding of CD48-2B4 (show CD244 Proteins) protein complexes.
These data demonstrate the important role of CD48 in SA/exotoxins-eosinophil activating interactions that can take place during allergic responses and indicate CD48 as a novel therapeutic target for allergy and especially of AD.
ORMDL3 (show ORMDL3 Proteins) promotes eosinophil trafficking and activation via regulation of CD18 (show ITGB2 Proteins), CD49d, and CD48.
Ox-LDL significantly promoted the interaction of natural killer cells and dendritic cells via CD48-2B4 (show CD244 Proteins) contact-dependent mechanisms.
B6-specific background genes modulate the effect of CD48 on lupus nephritis in a recessive manner
CD48 plays a vital role as an environmental sensor for regulating hematopoietic stem cells and progenitor cell numbers and inhibiting tumor development
CD48 on surrounding NK or non-NK cells serves primarily as a ligand to stimulate 2B4 (show CD244 Proteins) on the adjacent NK cells in mice
CD137 (show TNFRSF9 Proteins) and CD28 (show CD28 Proteins) can promote bcl-2 (show BCL2 Proteins) expression at both mRNA and protein level in T cells.
molecular mechanism of heterophilic adhesion between the murine T-cell adhesion glycoprotein (show CD226 Proteins) CD2 (show CCND2 Proteins) and its ligand CD48
CD48 interactions with NK cell receptor 2B4 (show CD244 Proteins) among neighboring T cells during T cell priming augment CTL lysis of their specific targets.
CD48 expression was increased in patients with a short disease duration compared to both controls and patients with longer disease duration. In patients with short disease duration, increased CD48 expression was associated with alveolar inflammation.
Blockade of 2B4 (show CD244 Proteins)/CD48 interaction resulted in improvement in function via perforin (show PRF1 Proteins) expression and degranulation as measured by CD107a (show LAMP1 Proteins) surface mobilization on HTLV-1 specific CD8 (show CD8A Proteins)+ T cells.
we propose that SLAMF2 engagement regulates adaptive immune responses
Monocyte-induced natural killer cell dysfunction was markedly attenuated by blocking CD48 receptor 2B4 (show CD244 Proteins) on NK cells, but not by blockade of NKG2D (show KLRK1 Proteins) and NKp30 (show NCR3 Proteins).
replication study of association of 2 SNPs in HERV-K18 (show KRT18 Proteins) and 19 tagSNPs in CD48 with schizophrenia (SZ)and type 2 diabetes (T2D) in patients with SZ in 2 Danish samples; no association was found with SZ or with T2D among individuals with SZ for any of the SNPs
Stimulation of CD48 induces rearrangement of signaling factors in lipid rafts, Lck (show LCK Proteins)-kinase activity, and tyrosine phosphorylation.
The ligand (CD48) of the 2B4 (show CD244 Proteins) receptor can exert both activating and inhibiting signals; natural killer (NK) cells might be at risk for self-killing were it not for the inhibiting signals generated by the 2B4 (show CD244 Proteins)-CD48 interaction.
CM1-induced apoptosis is achieved via different initiation pathways, which are cell-type dependent
Signal-dependent adhesion of resting NK cells initiated by expression of ICAM-1 (show ICAM1 Proteins) is greatly enhanced by coexpression of CD48, even in the absence of cytokines.
This gene encodes a member of the CD2 subfamily of immunoglobulin-like receptors which includes SLAM (signaling lymphocyte activation molecules) proteins. The encoded protein is found on the surface of lymphocytes and other immune cells, dendritic cells and endothelial cells, and participates in activation and differentiation pathways in these cells. The encoded protein does not have a transmembrane domain, however, but is held at the cell surface by a GPI anchor via a C-terminal domain which maybe cleaved to yield a soluble form of the receptor. Multiple transcript variants encoding different isoforms have been found for this gene.
BCM1 surface antigen
, MRC OX-45 surface antigen
, SLAM family member 2
, signaling lymphocytic activation molecule 2
, CD48 antigen
, B-lymphocyte activation marker BLAST-1
, CD48 antigen (B-cell membrane protein)
, leukocyte antigen MEM-102