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May act as a receptor in regulating T-cell proliferation..
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Mouse (Murine) Monoclonal CD5 Primary Antibody for FACS - ABIN135108
Bikah, Carey, Ciallella, Tarakhovsky, Bondada: CD5-mediated negative regulation of antigen receptor-induced growth signals in B-1 B cells. in Science (New York, N.Y.) 1997
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Mouse (Murine) Monoclonal CD5 Primary Antibody for FACS - ABIN135111
Ledbetter, Herzenberg: Xenogeneic monoclonal antibodies to mouse lymphoid differentiation antigens. in Immunological reviews 1980
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Mouse (Murine) Monoclonal CD5 Primary Antibody for FACS - ABIN135106
Stanton, Stevens, Ledbetter, Wofsy: Anti-Ly-1 antibody induces interleukin 2 release from T cells. in Journal of immunology (Baltimore, Md. : 1950) 1986
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In mice lacking functional KDELR1, surviving naive T cells expressed significantly higher levels of CD5, a surrogate marker of TCR self-reactivity.
In mouse tumor models, CD5(+) but not CD5(-) B cells promoted tumor growth. The results demonstrate a critical role of CD5(+) B cells in promoting cancer.
CD5 and CD72 (show CD72 Antibodies) play a critical role in maintaining regulatory T and B cell homeostasis
CD5 promoted Treg cell induction in response to self and tolerizing antigens by blocking mTOR (show FRAP1 Antibodies) activation.
Data indicate that CD5-casein kinase 2 (CK2 (show CSNK2A1 Antibodies)) signaling is necessary for efficient nuclear localization of orphan nuclear receptor (show NR1D1 Antibodies) ROR (show RORB Antibodies)-gammaT (RORgammat).
These results support the notion that the distal cytoplasmic domain of CD5, including Y463, plays a relevant role in the downmodulation of TCR signals in thymocytes via c-Cbl (show CBL Antibodies).
Although the percentage of CD1d (show CD1D Antibodies)(hi)CD5+ subset in splenic B cells does not change significantly, percent IL-10 (show IL10 Antibodies)-expressing cells among total splenic B cells or the CD1dhiCD5+ population significantly increases 3-7 days after rCRT/39-272 administration
Different CD5 expression levels influence the proliferation dynamics of activated naive CD4 (show CD4 Antibodies)+ T cells while leaving the conversion rate of those cells into memory cells unaffected.
Data show several homologies across human, rat and mouse in the kinetic of loss of several LAgs such as CD5, CD4 (show CD4 Antibodies) and CD28 (show CD28 Antibodies).
CD5 glycoprotein-mediated T cell inhibition dependent on inhibitory phosphorylation of Fyn (show FYN Antibodies) kinase
May act as a receptor in regulating T-cell proliferation.
T-cell surface glycoprotein CD5
, lymphocyte antigen 1