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May act as a receptor in regulating T-cell proliferation.. Additionally we are shipping CD5 Antibodies (1297) and CD5 Kits (16) and many more products for this protein.
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Human CD5 Protein expressed in HEK-293 Cells - ABIN2180809
Van de Velde, von Hoegen, Luo, Parnes, Thielemans: The B-cell surface protein CD72/Lyb-2 is the ligand for CD5. in Nature 1991
Show all 4 references for ABIN2180809
In mice lacking functional KDELR1, surviving naive T cells expressed significantly higher levels of CD5, a surrogate marker of TCR self-reactivity.
In mouse tumor models, CD5(+) but not CD5(-) B cells promoted tumor growth. The results demonstrate a critical role of CD5(+) B cells in promoting cancer.
CD5 and CD72 (show CD72 Proteins) play a critical role in maintaining regulatory T and B cell homeostasis
CD5 promoted Treg cell induction in response to self and tolerizing antigens by blocking mTOR (show FRAP1 Proteins) activation.
Data indicate that CD5-casein kinase 2 (CK2 (show CSNK2A1 Proteins)) signaling is necessary for efficient nuclear localization of orphan nuclear receptor (show NR1D1 Proteins) ROR (show RORB Proteins)-gammaT (RORgammat).
These results support the notion that the distal cytoplasmic domain of CD5, including Y463, plays a relevant role in the downmodulation of TCR signals in thymocytes via c-Cbl (show CBL Proteins).
Although the percentage of CD1d (show CD1D Proteins)(hi)CD5+ subset in splenic B cells does not change significantly, percent IL-10 (show IL10 Proteins)-expressing cells among total splenic B cells or the CD1dhiCD5+ population significantly increases 3-7 days after rCRT/39-272 administration
Different CD5 expression levels influence the proliferation dynamics of activated naive CD4 (show CD4 Proteins)+ T cells while leaving the conversion rate of those cells into memory cells unaffected.
Data show several homologies across human, rat and mouse in the kinetic of loss of several LAgs such as CD5, CD4 (show CD4 Proteins) and CD28 (show CD28 Proteins).
CD5 glycoprotein-mediated T cell inhibition dependent on inhibitory phosphorylation of Fyn (show FYN Proteins) kinase
CD5+B lymphocytes were increased and activated in autoimmune hemolytic anemia patients.
This study confirms the poor prognosis of de novo CD5+ DLBCL in a large multi-center cohort despite initial rituximab-containing chemotherapy and suggests that stem cell transplantation fails to salvage the majority of these patients.
5.2 % were positive for CD5 and 5.7 % positive for epstein-Barr virus encoded RNA
CD5 polymorphisms are associated with systemic lupus erythematosus.
three tyrosine-based domains within CD5 cytoplasmic tail promote T-cell survival through non-overlapping mechanisms
A case of mantle cell lymphoma with a unique pattern of CD5 negative to positive expression switching in relapse.
Data show that the proportion of CD5+ B cells at 1 mo of age is inversely correlated to total IgG levels at 18 and 36 mo of age.
down-regulation of CD5 on activated CD8 (show CD8A Proteins)(+) T cells may serve as a useful marker of dysregulated T cell activation and proliferation in FHL2 (show FHL2 Proteins).
CD5 expression in nodal marginal zone lymphoma correlates with a higher frequency of dissemination, but patients have an indolent clinical course and excellent overall survival.
Our results indicate that CD5(+) B cell subsets might be associated with pathogenesis of SPMS.
Findings suggest that development, selection and function of different B- and T-cell subsets may be directly or indirectly dependent on different glycan structures associated with CD5 or CD5-like (show CD5L Proteins) molecules expressed on T cells compared to B (show TDO2 Proteins) cells.
May act as a receptor in regulating T-cell proliferation.
, t-cell surface glycoprotein CD5-like
, T-cell surface glycoprotein CD5
, lymphocyte antigen 1
, CD5 antigen (p56-62)
, lymphocyte antigen T1/Leu-1
, CD5 antigen
, Lymphocyte antigen CD5
, CD74 antigen, invariant polypeptide of major
, lymphocyte receptor CD5