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Potent inhibitor of the complement membrane attack complex (MAC) action. Additionally we are shipping CD59a Antigen Antibodies (7) and and many more products for this protein.
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Mouse (Murine) CD59A Protein expressed in Human Cells - ABIN2008240
Turnberg, Botto, Lewis, Zhou, Sacks, Morgan, Walport, Cook: CD59a deficiency exacerbates ischemia-reperfusion injury in mice. in The American journal of pathology 2004
Varicella-zoster virus infection upregulates host CD59 (show CD59 Proteins) expression in a tissue-specific manner.
This study support a role of Cd59a (show CD59 Proteins) in controlling the innate immune status of the RPE (show RPE Proteins)-choroidal complex and emphasizes the particular vulnerability of this ocular compartment to the dysregulation of alternative complement pathway during aging
results implicate CD59 (show CD59 Proteins) as an important modulator of the immune response in NMO, and provide a novel animal model of NMO that closely recapitulates human NMO pathology.
Soluble forms of CD59 (show CD59 Proteins) (sCD59) have been investigated in mouse laser-induced choroidal neovascularization, a model for "wet" age related macular degeneration.
both CD59 (show CD59 Proteins) and C-PC could inhibit the progress of atherosclerosis, and the anti-atherosclerotic effects of C-PC might be fulfilled by promoting CD59 (show CD59 Proteins) expression, preventing smooth muscle cell proliferation and the apoptosis of endothelial cells
CD59a (show CD59 Proteins) inhibits systemic autoimmunity in MRL/lpr (show FAS Proteins) mice through a complement-independent mechanism.
While the connection between CFH (show CFH Proteins) deficiency and failure to upregulate CD59a (show CD59 Proteins) remains unknown, these results suggest that expression of CD59 (show CD59 Proteins) is tissue-specific and that neuroretinal regulation depends on CFH (show CFH Proteins).
Actively immunized experimental autoimmune myasthenia gravis mice deficient in either CD55 or CD59 showed significant differences in adaptive immune responses and worsened disease outcome associated with increased levels of serum cytokines, modified production of acetylcholine receptor antibodies, and more complement deposition at the neuromuscular junction.
HBx can up-regulate CD59 (show CD59 Proteins) and Crry (show CR1L Proteins) expression in podocytes through activating the P38 (show CRK Proteins) pathway.
CD59 (show CD59 Proteins) has a role in growth of the choroidal neovascular complex in mice
Potent inhibitor of the complement membrane attack complex (MAC) action. Acts by binding to the C8 and/or C9 complements of the assembling MAC, thereby preventing incorporation of the multiple copies of C9 required for complete formation of the osmolytic pore (By similarity).
, CD59A glycoprotein
, MAC-inhibitory protein
, membrane attack complex inhibition factor