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CD6 encodes a protein found on the outer membrane of T-lymphocytes as well as some other immune cells. Additionally we are shipping CD6 Antibodies (410) and CD6 Proteins (15) and many more products for this protein.
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these data indicate that CD6 modulates the threshold for thymocyte selection and the generation and/or function of several peripheral T cell subpopulations, including T reg (show KCNH2 ELISA Kits) cells
results reveal an unexpected role of CD6 in the pathogenesis of intestinal IR-induced injury by regulating the self-renewal of B1a cells.
this analysis identified 65 proteins not associated before with the Zap70 (show ZAP70 ELISA Kits)-Lat (show LAT ELISA Kits)-SLP-76 (show LCP2 ELISA Kits) network and thus should provide cues for future functional experiments.
These data are consistent with a model in which bivalent recruitment of a GADS (show GRAP2 ELISA Kits)/SLP-76 (show LCP2 ELISA Kits) complex is required for costimulation by CD6.
Data indicate that the T cell-specific adaptor protein (TSAd) SH2 domain interacts with CD6 antigen and linker for activation of T cells (show LAT ELISA Kits) protein (LAT (show ORC3 ELISA Kits)) phosphotyrosine (pTyr) peptides.
Results from recent genetic association studies provide evidence for a role of CD6 in multiple sclerosis and in rheumatoid arthritis pathogenesis. [review]
Study provides evidence on the role of CD6, a lymphocyte-specific surface receptor from to the ancient and highly conserved Scavenger Receptor Cysteine-Rich (SRCR) superfamily, as a pattern recognition receptor, and the functional consequences this may have on T cell activation and differentiation. [review]
Data show the multiple aspects that determine the nature of the signals transmitted via CD6 and the context that may define a dual role for this important T cell surface molecule (show CD8A ELISA Kits). [review]
Data show a role for extracellular and intracellular interactions of CD6 in lateral movement in response to T cell activation. [review]
The binding sites on CD6 and CD166 (show ALCAM ELISA Kits) have been characterized to show that a SNP in CD6 causes glycosylation that hinders the CD6/CD166 (show ALCAM ELISA Kits) interaction.
CD6 regulatory T cells are characterized by CD6 expression and FOXP3 (show FOXP3 ELISA Kits) expression.
interaction of Galectin-1 (show LGALS1 ELISA Kits) and -3 with CD6
upon T cell activation, SRSF1 (show SRSF1 ELISA Kits) becomes limiting, and its function in CD6 exon 5 splicing is countered by an increase in CD6 transcription, dependent on chromatin acetylation.
This gene encodes a protein found on the outer membrane of T-lymphocytes as well as some other immune cells. The encoded protein contains three scavenger receptor cysteine-rich (SRCR) domains and a binding site for an activated leukocyte cell adhesion molecule. The gene product is important for continuation of T cell activation. This gene may be associated with susceptibility to multiple sclerosis (PMID: 19525953, 21849685). Multiple transcript variants encoding different isoforms have been found for this gene.
T-cell differentiation antigen CD6
, CD6 antigen
, CD6 antigen, Tp120