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The protein encoded by CD63 is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Additionally we are shipping CD63 Kits (24) and CD63 Proteins (18) and many more products for this protein.
Showing 10 out of 533 products:
Human Monoclonal CD63 Primary Antibody for ICC, FACS - ABIN94215
Cerny, Feng, Yu, Miyake, Borgonovo, Klumperman, Meldolesi, McNeil, Kirchhausen: The small chemical vacuolin-1 inhibits Ca(2+)-dependent lysosomal exocytosis but not cell resealing. in EMBO reports 2004
Show all 7 references for ABIN94215
Human Monoclonal CD63 Primary Antibody for ICC, FACS - ABIN1027697
Mantegazza, Barrio, Moutel, Bover, Weck, Brossart, Teillaud, Mordoh: CD63 tetraspanin slows down cell migration and translocates to the endosomal-lysosomal-MIICs route after extracellular stimuli in human immature dendritic cells. in Blood 2004
Show all 7 references for ABIN1027697
Human Monoclonal CD63 Primary Antibody for FACS - ABIN457392
Lin, Kamsteeg, Zhang, Jin, Sterling, Yue, Roos, Duffield, Spencer, Caplan, Wang: Expression of tetraspan protein CD63 activates protein-tyrosine kinase (PTK) and enhances the PTK-induced inhibition of ROMK channels. in The Journal of biological chemistry 2008
Show all 6 references for ABIN457392
Human Monoclonal CD63 Primary Antibody for FACS - ABIN192268
Israels, McMillan-Ward: CD63 modulates spreading and tyrosine phosphorylation of platelets on immobilized fibrinogen. in Thrombosis and haemostasis 2005
Show all 6 references for ABIN192268
Human Monoclonal CD63 Primary Antibody for ICC, FACS - ABIN94214
Pfistershammer, Majdic, Stöckl, Zlabinger, Kirchberger, Steinberger, Knapp: CD63 as an activation-linked T cell costimulatory element. in Journal of immunology (Baltimore, Md. : 1950) 2004
Show all 5 references for ABIN94214
Human Monoclonal CD63 Primary Antibody for FACS, ICC - ABIN262837
Chow, Zhou, Liu, Fong, Champer, Van Haute, Chin, Ren, Gugiu, Meng, Huang, Ngo, Kortylewski, Wang: Macrophage immunomodulation by breast cancer-derived exosomes requires Toll-like receptor 2-mediated activation of NF-κB. in Scientific reports 2014
Show all 5 references for ABIN262837
Human Monoclonal CD63 Primary Antibody for FACS - ABIN94216
Grützkau, Smorodchenko, Lippert, Kirchhof, Artuc, Henz: LAMP-1 and LAMP-2, but not LAMP-3, are reliable markers for activation-induced secretion of human mast cells. in Cytometry. Part A : the journal of the International Society for Analytical Cytology 2004
Show all 5 references for ABIN94216
Human Monoclonal CD63 Primary Antibody for ICC, FACS - ABIN610177
Birikh, Sklan, Shoham, Soreq: Interaction of "readthrough" acetylcholinesterase with RACK1 and PKCbeta II correlates with intensified fear-induced conflict behavior. in Proceedings of the National Academy of Sciences of the United States of America 2003
Show all 2 references for ABIN610177
Human Monoclonal CD63 Primary Antibody for FACS, IF - ABIN120614
Schmidt, Gelhaus, Nebendahl, Lettau, Lucius, Leippe, Kabelitz, Janssen: Effector granules in human T lymphocytes: the luminal proteome of secretory lysosomes from human T cells. in Cell communication and signaling : CCS 2011
Data show that CD63 is a crucial player in the regulation of the tumor cell-intrinsic metastatic potential by affecting cell plasticity.
These findings identify CD63 as an important component of allergic inflammation.
CD63 serves to bridge between beta1 integrin and VEGFR2 (show KDR Antibodies) because CD63 silencing disrupted VEGFR2 (show KDR Antibodies)-beta1 integrin complex formation identified using proximity ligation assay
Loss of CD63 is associated impairment of amyloidogenesis and downstream melanosome morphogenesis.
Loss of CD63 has a similar phenotype to loss of P-selectin (show SELP Antibodies) itself, thus CD63 is an essential cofactor to P-selectin (show SELP Antibodies).
CXCR4 (show CXCR4 Antibodies) can be downregulated on activated B cells by IL-21 (show IL21 Antibodies)-induced endocytosis and CD63-mediated endosomal recruitment.
The findings identify palmitoylation-dependent association with the tetraspanin CD63 as the mechanism by which Syt VII (show SYT7 Antibodies) is targeted to lysosomes.
CD63, but not RILP (show RILP Antibodies), is recruited to the phagosomes in macrophages expressing the dominant negative form of Rab7 (show RAB7A Antibodies).
CD63 is recruited to already-budded Weibel-Palade bodies by an AP-3-dependent route
Upon phagocytosis of Cryptococcus neoformans and polystyrene beads, CD63 was recruited selectively to C. neoformans-containing phagosomes in a MyD88 (show MYD88 Antibodies)-independent acidification-dependent manner
CD163 (show CD163 Antibodies)(+) TAMs in oral premalignant lesions coexpress CD163 (show CD163 Antibodies) and STAT1 (show STAT1 Antibodies), suggesting that the TAMs in oral premalignant lesions possess an M1 phenotype in a Th1 (show TH1L Antibodies)-dominated micromilieu.
Our findings reveal that elevated levels of TIMP-1 (show TIMP1 Antibodies) impact on neutrophil homeostasis via signaling through CD63.
These findings indicate that rhTIMP-1 promotes clonogenic expansion and survival in human progenitors via the activation of the CD63/PI3K (show PIK3CA Antibodies)/pAkt (show AKT1 Antibodies) signaling pathway
It was shown that treatment of macrophages with anti-CD63 inhibits CCR5 (show CCR5 Antibodies)-mediated virus infection in a cell type-specific manner, but that no inhibition of CXCR4 (show CXCR4 Antibodies)-tropic viruses occurs.
TM4SF5 interacted with CD151 (show CD151 Antibodies), and caused the internalization of CD63 from the cell surface.
Diesel exhaust exposure during exercise induces platelet activation as illustrated by a dose-response increase in the release of CD62P (show SELP Antibodies) and CD63.
CD63 tetraspanin is a negative driver of epithelial-to-mesenchymal transition in human melanoma cells.
these results indicated that high glycosylation of CD63 by RPN2 (show PSMD1 Antibodies) is implicated in clinical outcomes in breast cancer patients
CD9 (show CD9 Antibodies) and CD63 tetraspanins block HIV-1-induced cell-cell fusion at the transition from hemifusion to pore opening.
The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. The encoded protein is a cell surface glycoprotein that is known to complex with integrins. It may function as a blood platelet activation marker. Deficiency of this protein is associated with Hermansky-Pudlak syndrome. Also this gene has been associated with tumor progression. Alternative splicing results in multiple transcript variants encoding different protein isoforms.
melanoma 1 antigen
, CD63 antigen
, CD63 antigen (melanoma 1 antigen)
, lysosomal-associated membrane protein 3
, lysosome-associated membrane glycoprotein 3
, melanoma-associated antigen ME491
, melanoma-associated antigen MLA1
, ocular melanoma-associated antigen
, ME491/CD63 antigen
, mast cell antigen AD1