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CD69 encodes a member of the calcium dependent lectin superfamily of type II transmembrane receptors. Additionally we are shipping CD69 Antibodies (400) and CD69 Kits (19) and many more products for this protein.
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Human CD69 Protein expressed in HEK-293 Cells - ABIN2180825
Natarajan, Sawicki, Margulies, Mariuzza: Crystal structure of human CD69: a C-type lectin-like activation marker of hematopoietic cells. in Biochemistry 2001
Show all 3 references for ABIN2180825
Data show that after tumor necrosis factor alpha-induced protein 8 like-2 (TIPE2 (show TNFAIP8L2 Proteins)) gene was down-regulated, the expression of the CD69 antigen was increased, and the proliferation of T lymphocytes and the secretion of cytokines IL-2 (show IL2 Proteins) and IFN-gamma (show IFNG Proteins) were enhanced.
The generation of cancer-specific CD8 (show CD8A Proteins)(+) CD69(+)-expressing lymphocytes that inhibit colon cancer growth has been described.
Maintenance of immune tolerance by Foxp3 (show FOXP3 Proteins)+ regulatory T cells requires CD69 expression.
AIM(-/-) mice were highly susceptible to steatosis-associated HCC (show FAM126A Proteins) development, whereas no AIM(+/+) mouse developed the disease despite comparable liver inflammation and fibrosis in response to a long-term high-fat diet.
CD69 interference with S1P1 (show S1PR1 Proteins) function regulates peripheral T cell retention.
The NKG2A (show KLRC1 Proteins) expression was increased in hepatic CD69-NK cells.
Report role of ZAP-70 (show ZAP70 Proteins) kinase mutation/deletion on thymocyte-positive selection via CD69 signaling.
The early activation marker CD69 regulates the expression of chemokines and CD4 (show CD4 Proteins) T cell accumulation in intestine.
Data indicate that CD69 is upregulated on endogenous dendritic cells (DC) upon activation.
Intron I acts as an important regulatory element of CD69 expression.
Higher CD69 expression were less sensitive to bendamustine and is associated with chronic lymphocytic leukemia.
In vitro functional assays showed that CD69(+) Treg cells exerted an important suppressive effect on the activation of T effector cells
results demonstrate the functional and mechanistic interplays between CD69 and S100A8 (show S100A8 Proteins)/S100A9 (show S100A9 Proteins) in supporting Treg-cell differentiation
Elevated expression of CD69 and CD161 (show KLRB1 Proteins) on NK cells can be considered as immunological risk markers in RSA and IVF (show SCN5A Proteins) failure.
Human tumor-infiltrating CD4 (show CD4 Proteins)+CD69+ T cells suppress T cell proliferation via membarene -bound TGF-beta1 (show TGFB1 Proteins).
these findings identify CD69 and galectin-1 (show LGALS1 Proteins) to be a novel regulatory receptor-ligand pair that modulates Th17 effector cell differentiation and function.
REVIEW: CD69 exerts a complex immunoregulatory role in humans, and that it could be considered as a target molecule for the therapy of immune-mediated diseases
Following coculture with GTKO/CD46 (show CD46 Proteins) pig mesenchymal stromal cells, it is possible that upregulation of CD69 on human T cells initiates signaling events that would regulate CD4 (show CD4 Proteins)+ and CD8 (show CD8A Proteins)+ T cell activation and differentiation.
In patients with allergic rhinitis CD69 antigen is overexpressed on human peripheral blood natural killer cells reflecting their activation status.
This is the first report of the regulation of CD69 expression by LMP-1 (show PDLIM7 Proteins), and this novel finding may, thus, represent an important link between the EBV oncoprotein LMP-1 (show PDLIM7 Proteins) and its critical role in the development of EBV-associated diseases.
This gene encodes a member of the calcium dependent lectin superfamily of type II transmembrane receptors. Expression of the encoded protein is induced upon activation of T lymphocytes, and may play a role in proliferation. Furthermore, the protein may act to transmit signals in natural killer cells and platelets.
, early activation antigen CD69
, Very Early Activation Antigen
, C-type lectin domain family 2, member C
, CD69 antigen (p60, early T-cell activation antigen)
, activation inducer molecule (AIM/CD69)
, early T-cell activation antigen p60
, early lymphocyte activation antigen
, leukocyte surface antigen Leu-23