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Plays a role in B-cell proliferation and differentiation..
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CD72 negatively regulates mouse mast cell functions and down-regulates the expression of KIT and FcepsilonRIalpha.
CD5 (show CD5 Antibodies) and CD72 play a critical role in maintaining regulatory T and B cell homeostasis
These results strongly suggest that the Cd72(c) is a crucial modifier gene that regulates Fas(lpr (show FAS Antibodies))-induced autoimmune disease due to its reduced activity of B cell signal regulation.
Cd72 polymorphism affects susceptibility to lupus phenotypes.
Inhibitory coreceptors CD72 and CD22 (show CD22 Antibodies) are responsible for setting the requirement of CD40 (show CD40 Antibodies) signaling for survival and proliferation of antigen-stimulated spleen B cells.
results strongly suggest that the apoptosis preventing signal evoked by CD72 ligation is delivered through the pathway of NF-kappaB (show NFKB1 Antibodies), c-Myc (show MYC Antibodies), p27(Kip1 (show CDKN1B Antibodies)) and cyclin (show PCNA Antibodies)
Strength of B-cell antigen receptor signals is strictly tuned by the interaction of CD100 (show SEMA4D Antibodies) with CD72; this interaction is essential for maintaining immunological homeostasis as well as generating a proper immune response.
CD72 plays a dominant role as a negative regulator of BCR (show BCR Antibodies) signaling in primary mature B lymphocytes.
CD72 is required to maintain B cell anergy and functions as a regulator of peripheral B cell tolerance
CD72 is an inhibitory receptor on NK cells regulating cytokine production.
Plays a role in B-cell proliferation and differentiation.
B-cell differentiation antigen CD72
, lymphocyte antigen 32