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Identifies cytotoxic/suppressor T-cells that interact with MHC class I bearing targets.
Mouse (Murine) Monoclonal CD8A Primary Antibody for FACS, IHC - ABIN135122
Lefrançois: Extrathymic differentiation of intraepithelial lymphocytes: generation of a separate and unequal T-cell repertoire? in Immunology today 1992
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Mouse (Murine) Monoclonal CD8A Primary Antibody for FACS, IP - ABIN135118
Ledbetter, Seaman: The Lyt-2, Lyt-3 macromolecules: structural and functional studies. in Immunological reviews 1983
Show all 6 references for ABIN135118
Mouse (Murine) Monoclonal CD8A Primary Antibody for FACS, IHC - ABIN135120
Ledbetter, Rouse, Micklem, Herzenberg: T cell subsets defined by expression of Lyt-1,2,3 and Thy-1 antigens. Two-parameter immunofluorescence and cytotoxicity analysis with monoclonal antibodies modifies current views. in The Journal of experimental medicine 1980
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Mouse (Murine) Monoclonal CD8A Primary Antibody for FACS, IHC - ABIN135123
Lefrancois: Phenotypic complexity of intraepithelial lymphocytes of the small intestine. in Journal of immunology (Baltimore, Md. : 1950) 1991
Show all 5 references for ABIN135123
Mouse (Murine) Monoclonal CD8A Primary Antibody for FACS, IP - ABIN135121
Takahasi, Kondou, Watanabe, Noro, Makiishi, Ishikawa: [Investigation of etching and bonding on the inner surface of free enamel. SEM observation and thermal cycling test for pigment invasion] in Shika gakuho. Dental science reports 1990
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The generation of cancer-specific CD8(+) CD69 (show CD69 Antibodies)(+)-expressing lymphocytes that inhibit colon cancer growth has been described.
TCF-1-deficient CD4+ CD8+ double positive thymocytes fail to undergo TCR alpha Valpha14-Jalpha18 rearrangement and produce significantly fewer Natural killer T cells.
Batf3 (show BATF3 Antibodies) deficiency is not critical for the generation of CD8alpha dendritic cells
Lck (show LCK Antibodies)-CD8 interaction is required for initial CD8 recruitment.
Brd1 (show BRD1 Antibodies)-mediated Hbo1 (show MYST2 Antibodies) activity is crucial for efficient activation of CD8 expression via acetylation at H3K14, which serves as an epigenetic mark that promotes the recruitment of transcription machinery to the CD8 enhancers.
Ly49E is expressed on a high proportion of CD8alphaalpha-positive intestinal intraepithelial lymphocytes.
Comparing the sequences of mouse, human, rat and dog Cd8a and Cd8b1 gene loci identified 10 evolutionarily conserved regions (ECR). 6 ECRs overlapped with previously identified Cd8 enhancers. ECR-4 recruits transcription factors to the Cd8ab gene complex.
Data indicate that orphan G-protein-coupled receptor (show GPRC5C Antibodies) GPR18 (show GPR18 Antibodies) is required for the normal homeostasis of CD8alphaalpha gammadeltaT and alphabetaT and CD8alphabeta intestinal intraepithelial lymphocyte compartment.
CD8alpha DCs, rather than CD8 T cells, are responsible for enhanced viral latency and recurrences.
Downregulation of CD8 during type 2 olarization of murine CD8(+) effector T cells is associated with CpG methylation of several regions of the Cd8a locus.
Identifies cytotoxic/suppressor T-cells that interact with MHC class I bearing targets. CD8 is thought to play a role in the process of T-cell mediated killing. CD8 alpha chains binds to class I MHC molecules alpha-3 domains.
Lyt-2.1 lymphocyte differentiation antigen (AA at 100)
, T-cell surface glycoprotein CD8 alpha chain
, T-cell surface glycoprotein Lyt-2
, CD8 alpha
, CD8 antigen, alpha polypeptide
, T-cell surface glycoprotein CD8 alpha chain-like