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The CD8 antigen is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system. Additionally we are shipping CD8B Proteins (20) and CD8B Kits (7) and many more products for this protein.
Showing 10 out of 346 products:
Human Monoclonal CD8B Primary Antibody for FACS, IP - ABIN118499
DiSanto, Terry, Flomenberg: Generation of anti-human CD8 beta-specific antibodies using transfectants expressing mixed-species CD8 heterodimers. in Journal of immunological methods 1991
Show all 6 references for ABIN118499
Mouse (Murine) Monoclonal CD8B Primary Antibody for CyTox - ABIN114180
Raulet, Gottlieb, Bevan: Fractionation of lymphocyte populations with monoclonal antibodies specific for LYT-2.2 and LYT-3.1. in Journal of immunology (Baltimore, Md. : 1950) 1980
Show all 4 references for ABIN114180
Human Polyclonal CD8B Primary Antibody for EIA, WB - ABIN356930
Nakayama, Kawachi, Tokito, Minami, Yamamoto, Imai, Gachelin, Nakauchi: Recent duplication of the two human CD8 beta-chain genes. in Journal of immunology (Baltimore, Md. : 1950) 1992
Show all 3 references for ABIN356930
Rat (Rattus) Monoclonal CD8B Primary Antibody for FACS - ABIN951407
Torres-Nagel, Kraus, Brown, Tiefenthaler, Mitnacht, Williams, Hünig: Differential thymus dependence of rat CD8 isoform expression. in European journal of immunology 1992
Show all 2 references for ABIN951407
Rat (Rattus) Monoclonal CD8B Primary Antibody for FACS - ABIN951409
Elflein, Rodriguez-Palmero, Kerkau, Hünig: Rapid recovery from T lymphopenia by CD28 superagonist therapy. in Blood 2003
Show all 2 references for ABIN951409
Mouse (Murine) Monoclonal CD8B Primary Antibody for FACS - ABIN114182
Ledbetter, Herzenberg: Xenogeneic monoclonal antibodies to mouse lymphoid differentiation antigens. in Immunological reviews 1980
Dog (Canine) Polyclonal CD8B Primary Antibody for WB - ABIN2775290
Moody, North, Reinhold, Van Dyken, Rogers, Panico, Dell, Morris, Marth, Reinherz: Sialic acid capping of CD8beta core 1-O-glycans controls thymocyte-major histocompatibility complex class I interaction. in The Journal of biological chemistry 2003
Lck (show LCK Antibodies)-CD8 (show CD8A Antibodies) interaction is required for initial CD8 (show CD8A Antibodies) recruitment.
Comparing the sequences of mouse, human, rat and dog Cd8a and Cd8b1 gene loci identified 10 evolutionarily conserved regions (ECR). 6 ECRs overlapped with previously identified Cd8 enhancers. ECR-4 recruits transcription factors to the Cd8ab gene complex.
CREMalpha orchestrates epigenetic remodeling of the CD8A (show CD8A Antibodies),B through the recruitment of DNA methyltransferase (show DNMT1 Antibodies) (DNMT (show DNMT1 Antibodies)) 3a and histone methyltransferase G9a (show EHMT2 Antibodies).
We propose that ADP-ribosylation of CD8 (show CD8A Antibodies)-beta can regulate the coreceptor function of CD8 (show CD8A Antibodies) in the presence of elevated levels of extracellular NAD(+) .
sialylation in a discrete segment of the CD8beta stalk by ST3Gal-1 sialyltransferase creates a molecular developmental switch that affects ligand binding
Data demonstrate that major histocompatibility complex-I-signaled thymocytes appear as CD4 (show CD4 Antibodies)+8lo cells because of transient down-regulation of CD8 (show CD8A Antibodies) gene expression, not because of changes in CD8 (show CD8A Antibodies) surface protein expression or distribution.
The stalk region of CD8 (show CD8A Antibodies) beta is capable of fine-tuning the coreceptor function of CD8 (show CD8A Antibodies) proteins as a coreceptor, possibly due to its distinct protein structure, smaller physical size and the unique glycan adducts associated with this region.
results demonstrate epigenetic control of the Cd8 (show CD8A Antibodies) loci and identify MAZR (show ZNF278 Antibodies) as an important regulator of Cd8 (show CD8A Antibodies) expression
The crystal structure of the CD8alphabeta immunoglobulin-like ectodomains were determined in complex with mAb YTS156.7 Fab (show FANCB Antibodies) at 2.7 A resolution, was elucidated.
The stalk region of CD8beta influences the ability of CD8 (show CD8A Antibodies) to bind class I major histocompatibility complexes and is therefore critical for the correct functioning of CD8alphabeta heterodimers.
transcription factor cAMP-responsive element modulator (show CREM Antibodies) alpha (CREMalpha), which is expressed at increased levels in T cells from systemic lupus erythematosus patients, contributes to transcriptional silencing of CD8A (show CD8A Antibodies) and CD8B.
A clustering of DNase (show DNASE2 Antibodies) hypersensitivity sites and matrix attachment regions capable of binding SATB1 (show SATB1 Antibodies) and GATA-3 (show GATA3 Antibodies), colocalized at the 3' end of the CD8B gene, suggests that this region is an epigenetic regulator of CD8 (show CD8A Antibodies) expression.
RT-PCR, and related methodologies are not useful substitutes for assessment of CD4 (show CD4 Antibodies) and CD8 (show CD8A Antibodies) cell numbers in HIV-infected persons.
study demonstrated differential mRNA expression patterns of CD8beta splice variants in thymocytes and in resting, memory, and activated primary CD8 (show CD8A Antibodies)(+) T cells
Data show that CD8 (show CD8A Antibodies)+LAP+ cells produce IFN-gamma (show IFNG Antibodies), and these cells suppress EAE that is dependent on both TGF-beta (show TGFB1 Antibodies) and IFN-gamma (show IFNG Antibodies).
The CD8 antigen is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system. The CD8 antigen, acting as a coreceptor, and the T-cell receptor on the T lymphocyte recognize antigens displayed by an antigen presenting cell (APC) in the context of class I MHC molecules. The functional coreceptor is either a homodimer composed of two alpha chains, or a heterodimer composed of one alpha and one beta chain. Both alpha and beta chains share significant homology to immunoglobulin variable light chains. This gene encodes the CD8 beta chain isoforms. Multiple alternatively spliced transcript variants encoding distinct membrane associated or secreted isoforms have been described. A pseudogene, also located on chromosome 2, has been identified.
, CD8 beta-2
, T-cell surface glycoprotein CD8 beta chain
, CD8 antigen beta polypeptide
, T-cell membrane glycoprotein Ly-3
, T-cell surface glycoprotein Lyt-3
, lymphocyte antigen 3
, CD8 antigen, beta polypeptide 1 (p37)
, T lymphocyte surface glycoprotein beta chain
, CD8 antigen 37 kDa chain
, CD8 antigen beta-chain
, CD8 antigen, beta chain
, CD8 antigen, beta-chain
, OX-8 membrane antigen
, CD8 beta chain
, CD8 antigen, beta polypeptide
, CD8b antigen