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CD97 encodes a member of the EGF-TM7 subfamily of adhesion G protein-coupled receptors, which mediate cell-cell interactions. Additionally we are shipping CD97 Antibodies (231) and CD97 Kits (14) and many more products for this protein.
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We conclude that CD97 is located in the SR and at the peripheral sarcolemma of human and murine skeletal muscle, where its absence affects the structure of the SR without impairing skeletal muscle function
Intestinal enlargement by CD97 requires its seven-span transmembrane/cytoplasmic C-terminal fragment.
CD55 (show CD55 Proteins) downregulates CD97 surface expression on circulating leukocytes by a process that requires physical forces.
Insight into a role for CD55 (show CD55 Proteins) interaction with CD97 in the pathogenesis of rheumatoid arthritis suggest that therapeutic strategies that disrupt CD55 (show CD55 Proteins)/CD97 may be clinically beneficial.
In vivo findings in experimental colitis and pneumococcal pneumonia indicate an essential role for CD97 in the migration of neutrophils.
CD97 plays a role in peripheral granulocyte homeostasis by functioning in an adhesive capacity.
Mobilization was absent and neutrophils were reduced in mice receiving CD97 mAb plus interleukin-8 (show IL8 Proteins), while granulocyte-colony stimulating factor (show CSF3 Proteins)-induced mobilization remained unaltered by anti-CD97. CD97 has a role in IL-8 (show IL8 Proteins) induced HSC (show FUT1 Proteins)/HPC mobilization.
In BALB/c mice, CD97 expression can be applied to almost completely separate colony-forming cells and cells exhibiting radioprotective capacity.
Despite the broad expression pattern of wild-type murine CD97, the successfully deleted gene Cd97-deficient mouse that is created has no overt phenotype, except for a mild granulocytosis that is normal in the absence of CD97.
Knock down of CD97 led to an altered mechanical phenotype, reduced adhesion to a stromal layer and lower wildtype FLT3 (show FLT3 Proteins) expression.
present study suggested that the expressions of CD97 antigen and decay accelerating factor(DAF (show CD55 Proteins)) were both upregulated in human cervical squamous cell carcinoma
CD97 promotes gastric cancer cell proliferation and invasion in vitro through exosome-mediated MAPK (show MAPK1 Proteins) signaling pathway, and exosomal miRNAs are probably involved in activation of the CD97-associated pathway.
we identify the specific isoforms of CD97, a novel pro-invasive glioma antigen, across histologic grades of glioma and within BTICs. We also demonstrate a trend towards increased CD97 expression among the classical and mesenchymal GBM subtypes.
CD97 enhanced TIMP-2 (show TIMP2 Proteins) secretion, leading to reduced MT-MMP-1 (show MMP14 Proteins) and -2 activities, impairing cell migration/invasion in vitro and lung macrometastasis in vivo and upregulating integrins. Both the NTF (show RHBDL2 Proteins) and the CTF (show NFIA Proteins) of CD97 were required.
These results provide the first experimental evidence that cd97 is a direct target of miR (show MLXIP Proteins)-126.
study reports gene expression in skeletal muscle tissue of women with metabolic syndrome is enriched in inflammatory response-related genes; IL6R (show IL6R Proteins), HDAC9 (show HDAC9 Proteins) and CD97 expression correlated negatively with insulin (show INS Proteins) sensitivity; suggests a role for these 3 inflammatory genes in development of skeletal muscle insulin (show INS Proteins) resistance in women
Lysophosphatidylethanolamine utilizes LPA(1 (show LPAR1 Proteins)) and CD97 in a breast cancer cell line.
CD97 expression promotes invasion and migration in glioblastoma multiforme, but has no effect on tumor proliferation.
This gene encodes a member of the EGF-TM7 subfamily of adhesion G protein-coupled receptors, which mediate cell-cell interactions. These proteins are cleaved by self-catalytic proteolysis into a large extracellular subunit and seven-span transmembrane subunit, which associate at the cell surface as a receptor complex. The encoded protein may play a role in cell adhesion as well as leukocyte recruitment, activation and migration, and contains multiple extracellular EGF-like repeats which mediate binding to chondroitin sulfate and the cell surface complement regulatory protein CD55. Expression of this gene may play a role in the progression of several types of cancer. Alternatively spliced transcript variants encoding multiple isoforms with 3 to 5 EGF-like repeats have been observed for this gene. This gene is found in a cluster with other EGF-TM7 genes on the short arm of chromosome 19.
, CD97 antigen
, leukocyte antigen CD97
, seven transmembrane helix receptor
, seven-span transmembrane protein
, seven-transmembrane, heterodimeric receptor associated with inflammation
, CD97 large isoform