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The protein encoded by CD99 is a cell surface glycoprotein involved in leukocyte migration, T-cell adhesion, ganglioside GM1 and transmembrane protein transport, and T-cell death by a caspase-independent pathway. Additionally we are shipping CD99 Antibodies (408) and CD99 Kits (28) and many more products for this protein.
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Human CD99 Protein expressed in HEK-293 Cells - ABIN2180861
Gelin, Aubrit, Phalipon, Raynal, Cole, Kaczorek, Bernard: The E2 antigen, a 32 kd glycoprotein involved in T-cell adhesion processes, is the MIC2 gene product. in The EMBO journal 1989
endothelial CD99 promotes leukocyte attachment to endothelium in inflamed vessels by a heterophilic ligand. In addition, CD99 binds to PILRs on neutrophils, an interaction that leads to increased shear resistance of the neutrophil attachment to ICAM-1 (show ICAM1 Proteins).
Endothelial CD99 signals through soluble adenylyl cyclase (show ADCY10 Proteins) and PKA to regulate leukocyte transendothelial migration.
role in membrane trafficking of CD99L2 (show CD99L2 Proteins) and in controlling transendothelial migration of leukocytes
CD99 plays a crucial role in the attenuation of graft-versus-host disease by regulating the expansion of myeloid-derived suppressor cells.
CD99L2 (show CD99L2 Proteins) and CD99 are involved in transendothelial migration of neutrophils in vitro and in the recruitment of neutrophils into inflamed peritoneum
These findings indicate that sialylated O-linked sugar structures on CD99 play an important role in the recognition of PILR.
Vaccination against CD99 inhibits atherogenesis in low-density lipoprotein receptor (show LDLR Proteins)-deficient mice.
Mouse CD99 is expressed on mouse leukocytes as well as enriched at the endothelial cell borders.
CD99 expression is increased in patients with active Inflammatory bowel disease, and positively correlated with disease activity.
CD99 counteracts EWS (show EWSR1 Proteins)-FLI1 (show FLI1 Proteins) in controlling NF-kappaB (show NFKB1 Proteins) signaling through the miR (show MLXIP Proteins)-34a, which is increased and secreted into exosomes released by CD99-silenced Ewing sarcoma cells.
these observations suggest that CD99 is involved in the regulation of CD1a (show CD1A Proteins) transcription and expression by increasing ATF-2 (show ATF2 Proteins).
CD99 was also paranuclear positive in 4 of 11 (36%) small cell lung carcinomas
Data show that CD99 antigen expression increased during in vitro differentiation of germinal center B cells and was highest in plasma cells (PCs).
Our results suggest that the CD34 (show CD34 Proteins)/CD25 (show IL2RA Proteins)/CD123 (show IL3RA Proteins)/CD99(+) LAIP is strictly associated with FLT3 (show FLT3 Proteins)-ITD-positive cells.
These results suggest that SEPTIN2-mediated cytoskeletal rearrangement and STATHMIN (show STMN1 Proteins)-mediated differentiation may contribute to changes in cell morphology and differentiation of H/RS cells with CD99 upregulation in Hodgkin lymphoma.
The results highlight an important role of CD99 in the differentiation and activity of human osteoblasts in physiological and pathological conditions.
CD99 can suppress CD98-mediated assembly of pro-tumorigenic signaling complexes through its ability to dephosphorylate focal adhesion kinase.
CD99 expression in astrocytomas of different malignant grades might contribute to the infiltrative ability and support the importance of CD99 as a potential target to reduce infiltrative astrocytoma capacity in migration and invasion.
The protein encoded by this gene is a cell surface glycoprotein involved in leukocyte migration, T-cell adhesion, ganglioside GM1 and transmembrane protein transport, and T-cell death by a caspase-independent pathway. In addition, the encoded protein may have the ability to rearrange the actin cytoskeleton and may also act as an oncosuppressor in osteosarcoma. Cyclophilin A binds to CD99 and may act as a signaling regulator of CD99. This gene is found in the pseudoautosomal region of chromosomes X and Y and escapes X-chromosome inactivation. Three transcript variants encoding different isoforms have been found for this gene.
paired immunoglobin-like type 2 receptor-ligand
, CD99 antigen
, E2 antigen
, MIC2 (monoclonal antibody 12E7)
, T-cell surface glycoprotein E2
, antigen identified by monoclonal 12E7, Y homolog
, antigen identified by monoclonal antibodies 12E7, F21 and O13
, surface antigen MIC2