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The protein encoded by CDC14A is a member of the dual specificity protein tyrosine phosphatase family. Additionally we are shipping CDC14A Antibodies (84) and many more products for this protein.
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We demonstrate that XCdc14A upregulation prevents targeting of exocyst and SNARE (show NAPA Proteins) complexes to the midbody, both essential for abscission to occur.
Cdc14B (show CDC14B Proteins) knockout (Cdc14B (show CDC14B Proteins)(-/-)) mouse embryonic fibroblasts showed defects in repairing ionizing radiation-induced DNA double-strand breaks, which occurred only at late passages when Cdc14A levels were low.
CDC14A regulates oocyte maturation and functions to promote the meiosis I-to-meiosis II transition as its homolog does in budding yeast.
These findings indicated that ZIPK (show DAPK3 Proteins) may also be involved in the regulation of the cell cycle in human cells, by interacting with HsCdc14A.
These data support the hypothesis that Cdc14A counteracts Cdk1 (show CDK1 Proteins)-cyclin B1 (show CCNB1 Proteins) activity through Wee1 (show WEE1 Proteins) dephosphorylation.
CDC (show CDK1 Proteins) (cell division cycle) 14A/B phosphatases associate with KIBRA (show WWC1 Proteins), and CDK1 (show CDK1 Proteins)-non-phosphorylatable KIBRA (show WWC1 Proteins) has greatly reduced interaction with CDC14B (show CDC14B Proteins).
Cdc14 phosphatase plays a role in cell cycle control in higher eukaryotes.
Cdc14A phosphatase prevents premature activation of Cdk1 (show CDK1 Proteins) regulating Cdc25A (show CDC25A Proteins) and Cdc25B (show CDC25B Proteins) at the entry into mitosis.
human HCT116, and human telomerase reverse transcription-immortalized retinal pigment epithelial cells deleted for Cdc14A are DNA damage checkpoint proficient and arrest efficiently in G2 in response to irradiation.
human Cdc14A phosphatase disrupts centrosome separation
hCdc14A and hCdc14B have functional homology to S. pombe Cdc25 and flp1
analysis of iron-responsive elements in the 3'UTR of CDC14a protein
hCdc14A is differentially expressed in human cancer cells and can interact with both p53 (show TP53 Proteins) and the Cdk1 (show CDK1 Proteins)/cyclin B complex; it may play a role in carcinogenesis
The protein encoded by this gene is a member of the dual specificity protein tyrosine phosphatase family. It is highly similar to Saccharomyces cerevisiae Cdc14, a protein tyrosine phosphatase involved in the exit of cell mitosis and initiation of DNA replication, suggesting a role in cell cycle control. This protein has been shown to interact with, and dephosphorylate tumor suppressor protein p53, and is thought to regulate the function of p53. Alternative splicing of this gene results in several transcript variants encoding distinct isoforms.
Dual specificity protein phosphatase CDC14A
, dual specificity protein phosphatase CDC14A
, CDC14 cell division cycle 14 homolog A
, cell division cycle 14 homolog A
, CDC14 homolog A
, CDC14 cell division cycle 14 homolog A (S. cerevisiae)
, dual specificity protein phosphatase CDC14A-like
, CDC10 (cell division cycle 10, S. cerevisiae, homolog)