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CDK5 Regulatory Subunit Associated Protein 2 (CDK5RAP2) ELISA Kits

CDK5RAP2 encodes a regulator of CDK5 (cyclin-dependent kinase 5) activity. Additionally we are shipping CDK5RAP2 Antibodies (26) and and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
CDK5RAP2 55755 Q96SN8
Anti-Mouse CDK5RAP2 CDK5RAP2 214444 Q8K389
Anti-Rat CDK5RAP2 CDK5RAP2 286919  
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Top CDK5RAP2 ELISA Kits at antibodies-online.com

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Catalog No. Reactivity Sensitivity Range Quantity Supplier Delivery Price Details
Human 4.68 pg/mL 18.75-1200 pg/mL 96 Tests Log in to see 11 to 13 Days
$910.56
Details

More ELISA Kits for CDK5RAP2 Interaction Partners

Human CDK5 Regulatory Subunit Associated Protein 2 (CDK5RAP2) interaction partners

  1. stabilization of the centrosome-spindle pole interface by the CEP215-HSET (show KIFC1 ELISA Kits) complex could promote survival of cancer cells containing supernumerary centrosomes.

  2. mouse expresses only one form of CDK5RAP2 that is equivalent to the human and rat alternatively spliced variant forms

  3. These results show that Cep169 targets microtubule tips and regulates stability of microtubules with CDK5RAP2.

  4. Cep68 degradation allows Cep215 removal from peripheral pericentriolar material (PCM (show PCMT1 ELISA Kits)) preventing centriole separation following disengagement, PCNT (show PCNT ELISA Kits) cleavage mediates Cep215 removal from core of the PCM (show PCMT1 ELISA Kits) to inhibit centriole disengagement and duplication

  5. LRRK1 regulates mitotic spindle orientation downstream of PLK1 (show PLK1 ELISA Kits) through CDK5RAP2-dependent centrosome maturation.

  6. The CEP215-pericentrin (show PCNT ELISA Kits) interaction is required for centrosome maturation and subsequent bipolar spindle formation during mitosis.

  7. DPP4, CDK5RAP2, and CCR6 are risk loci for rheumatoid arthritis in Han Chinese and congruence with risk variants in Europeans.

  8. results reveal a key role of the dynein-dynactin (show DCTN1 ELISA Kits) complex in the dynamic recruitment of CDK5RAP2 to centrosomes

  9. Human expression pattern of CDK5RAP2 is similar to that seen in mice and is in concordance with pathology suggested by neuroimaging studies in humans and mouse

  10. Sequencing of the coding exons and exon/intron splice junctions of the CDK5RAP2 gene identified homozygosity for the novel nonsense mutation, c.4441C > T (p.Arg1481*), in both affected sons

Mouse (Murine) CDK5 Regulatory Subunit Associated Protein 2 (CDK5RAP2) interaction partners

  1. mouse expresses only one form of CDK5RAP2 that is equivalent to the human and rat alternatively spliced variant forms

  2. this study revealed the presence of previously unknown splice variants of the Cdk5rap2 gene that are at least in part accountable for the lack of microcephaly in the mice.

  3. In Cdk5rap2-depleted neural embryonic stem cells there is an increase in cell death in differentiating cells.

  4. Mouse expression pattern of CDK5RAP2 is similar to that seen in humans and is in concordance with pathology suggested by neuroimaging studies in humans and mouse

  5. This study demonistrated that CDK5RAP2 is a key molecule that mediates functional interaction and is essential for centrosomal targeting of Aurora-A (show AURKA ELISA Kits).

  6. These results indicate that CDK5RAP2 is required to maintain centriole engagement and cohesion, thereby restricting centriole replication.

  7. Cdk5rap2 is highly expressed in the neural progenitor pool and its loss results in a depletion of apical progenitors and increased cell-cycle exit leading to premature neuronal differentiation

  8. The an mutation is a genomic inversion of exon 4 of Cdk5rap2, resulting in an in-frame deletion of exon 4 from the mRNA. Cdk5rap2(an/an) neuronal precursors exit the cell cycle prematurely and many undergo apoptosis.

CDK5RAP2 Antigen Profile

Antigen Summary

This gene encodes a regulator of CDK5 (cyclin-dependent kinase 5) activity. The protein encoded by this gene is localized to the centrosome and Golgi complex, interacts with CDK5R1 and pericentrin (PCNT), plays a role in centriole engagement and microtubule nucleation, and has been linked to primary microcephaly and Alzheimer's disease. Alternative splicing results in multiple transcript variants.

Gene names and symbols associated with CDK5RAP2

  • CDK5 regulatory subunit associated protein 2 (CDK5RAP2) antibody
  • CDK5 regulatory subunit associated protein 2 (cdk5rap2) antibody
  • CDK5 regulatory subunit associated protein 2 (Cdk5rap2) antibody
  • 2900018K03Rik antibody
  • an antibody
  • C48 antibody
  • Cep215 antibody
  • EGFL5 antibody
  • MCPH3 antibody
  • mKIAA1633 antibody

Protein level used designations for CDK5RAP2

CDK5 regulatory subunit-associated protein 2 , EGF-like-domain, multiple 5 , CDK5 regulatory subunit associated protein 2 , CDK5 regulatory subunit-associated protein 2-like , CDK5 activator-binding protein C48 , centrosomal protein 215 kDa

GENE ID SPECIES
508100 Bos taurus
612705 Canis lupus familiaris
771445 Gallus gallus
100156240 Sus scrofa
733952 Xenopus (Silurana) tropicalis
100071839 Equus caballus
100459050 Pongo abelii
55755 Homo sapiens
214444 Mus musculus
286919 Rattus norvegicus
464695 Pan troglodytes
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