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CMTM3 belongs to the chemokine-like factor gene superfamily, a novel family that is similar to the chemokine and the transmembrane 4 superfamilies of signaling molecules. Additionally we are shipping CMTM3 Proteins (3) and many more products for this protein.
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Reduced expression of CMTM3 is associated with prostate cancer.
CMTM1 (show CMTM1 Antibodies) and 3 are priority targets in glioblastomas. First insights into signalling of these two genes that might be conveyed by growth factor receptor (show RYK Antibodies), Src (show SRC Antibodies) family kinase and WNT (show WNT2 Antibodies) activation was presented.
Low expression of CMTM3 was associated with metastasis and recurrence of oral squamous cell carcinoma.
CMTM3 is significantly down-regulated in clear cell renal cell carcinoma (show MOK Antibodies) and exerts remarkable tumor-suppressive functions
Peritoneal disseminated metastases were significantly suppressed by CMTM3.
Bioinformatics based on CKLF2 (show CKLF Antibodies) cDNA and protein sequences in combination with experimental validation identified CKLFSF1 (show CMTM1 Antibodies)-8 gene clusters, between the SCY (show CELSR1 Antibodies) and the TM4SF (show TSPAN1 Antibodies) gene families. The 8 family members were cloned and characterized.
CMTM3/CKLFSF3 is an evolutionarily conserved gene that may have important roles in the male reproductive system and immune system.
CMTM3 inhibits prostate-specific antigen (show KLK3 Antibodies) expression at both mRNA and protein levels with no obvious influence on androgen receptor (show AR Antibodies) expression.
This gene belongs to the chemokine-like factor gene superfamily, a novel family that is similar to the chemokine and the transmembrane 4 superfamilies of signaling molecules. This gene is one of several chemokine-like factor genes located in a cluster on chromosome 16. Alternatively spliced transcript variants containing different 5' UTRs, but encoding the same protein, have been identified.
CKLF-like MARVEL transmembrane domain-containing protein 3
, chemokine-like factor super family 3
, CKLF-like MARVEL transmembrane domain containing 3
, chemokine-like factor superfamily member 3