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CMTM5 belongs to the chemokine-like factor gene superfamily. Additionally we are shipping CMTM5 Kits (32) and CMTM5 Proteins (3) and many more products for this protein.
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results indicate that CMTM5 is down-regulated in prostate cancer and exhibit tumor suppressor activities in androgen-independent prostate cancer cells
In the OSCC cell lines CAL27 and GNM, the ectopic expression of CMTM5-v1 strongly inhibited cell proliferation and migration and induced apoptosis.
The reduced expression of CMTM5 correlates significantly with poorly differentiated ovarian cancer and high preoperative CA125 (show MUC16 Antibodies) level.
Data suggest that CMTM5 may be involved in the pathomechanism of myeloid leukemias.
The expression level of cmtm5 gene is abnormally lower in the bone marrow cells from the multiple myeloma patients, and are associated with ISS stages.
HER2 (show ERBB2 Antibodies) was up regulated in prostate cancer epithelium while CMTM5 was down regulated. Overexpression of CMTM5 in PC3 (show PCSK1 Antibodies) cells could lower the HER2 (show ERBB2 Antibodies) and Cyclin D1 (show CCND1 Antibodies) protein level.
CMTM5-v1 might be secreted via a different vesicle-mediated secretory pathway, which will be helpful for the studies of vesicle-mediated secretion and MARVEL domain-containing proteins.
Bioinformatics based on CKLF2 (show CKLF Antibodies) cDNA and protein sequences in combination with experimental validation identified CKLFSF1 (show CMTM1 Antibodies)-8 gene clusters, between the SCY (show CELSR1 Antibodies) and the TM4SF (show TSPAN1 Antibodies) gene families. The 8 family members were cloned and characterized.
CMTM5 exhibits tumor suppressor activities, but with frequent epigenetic inactivation in carcinoma cell lines
These findings verify that CMTM5-v1 inhibits the growth of CC cell lines via inducing apoptosis.
This gene belongs to the chemokine-like factor gene superfamily. This family of genes encodes multi-pass membrane proteins that are similar to both the chemokine and the transmembrane 4 superfamilies of signaling molecules. Alternate transcriptional splice variants of this gene, encoding different isoforms, have been characterized.
CKLF-like MARVEL transmembrane domain-containing protein 5
, chemokine-like factor super family 5
, chemokine-like factor superfamily member 5
, chemokine-like factor super family five variant 4
, chemokine-like factor superfamily 5