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COX17 Cytochrome C Oxidase Assembly Homolog (S. Cerevisiae) Proteins (COX17)

Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. Additionally we are shipping COX17 Antibodies (43) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
COX17 10063 Q14061
Rat COX17 COX17 89786  
COX17 12856 P56394
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Top COX17 Proteins at antibodies-online.com

Showing 7 out of 8 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
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Yeast Wild boar His tag   1 mg Log in to see 56 to 66 Days
$2,057.00
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Yeast Dog His tag   1 mg Log in to see 56 to 66 Days
$2,060.67
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Yeast Yeast His tag   1 mg Log in to see 56 to 66 Days
$2,075.33
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Yeast Schizosaccharomyces pombe His tag   1 mg Log in to see 56 to 66 Days
$2,082.67
Details

COX17 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
,
Mouse (Murine)

More Proteins for COX17 Cytochrome C Oxidase Assembly Homolog (S. Cerevisiae) (COX17) Interaction Partners

Human COX17 Cytochrome C Oxidase Assembly Homolog (S. Cerevisiae) (COX17) interaction partners

  1. In addition to Atox1 (show ATOX1 Proteins), the human cytoplasm also contains Cu chaperones for loading of superoxide dismutase 1 (show SOD1 Proteins) (i.e. CCS (show CCS Proteins)) and cytochrome c (show CYCS Proteins) oxidase in mitochondria (i.e. Cox17). [review]

  2. Data show that the redox state of cytochrome c oxidase assembly protein 17 (Cox17), mitochondrial membrane transport protein Mia40 (show CHCHD4 Proteins) and superoxide dismutase 1 (SOD1 (show SOD1 Proteins)) in the cytoplasm were directly observed with in-cell NMR spectroscopy.

  3. Data suggest that Cox17 enhances the reactivity of some platinum/organoplatinum antineoplastic drugs but suppresses the reactivity of at least one platinum antineoplastic drug; glutathione modulates binding of platinum/organoplatinum drugs to Cox17.

  4. CTR1 (show SLC31A1 Proteins) silencing increased the protein levels of copper chaperone ATOX1 (show ATOX1 Proteins) and copper chaperone for superoxide dismutase (show CCS Proteins) 1 (show SOD1 Proteins) (CCS (show CCS Proteins)-1), but decreased copper chaperone for cytochrome c (show CYCS Proteins) oxidase (COX17).

  5. Functional role of two interhelical disulfide bonds in human Cox17 protein from a structural perspective.

  6. Data imply that up-regulation of COX17 function and increased cytochrome c (show CYCS Proteins) oxidase activity are frequent features of lung carcinogenesis.

  7. The binding of copper to Cox17 is needed to activate cytochrome c (show CYCS Proteins) oxidase by Cox17.

  8. Cox17-mediated copper metallation of Sco1, as well as the subsequent failure of Cu(A) site maturation, is the basis for the inefficient assembly of the cytochrome c oxidase complex in SCO1 patients

  9. Cox17 was studied with regard to its expression, purification, and formation of mixed disulfide adducts with sulfhydryl reagents.

  10. Cu(I)HCox17(2S-S), i.e., the copper-loaded form of the protein, can transfer simultaneously copper(I) and two electrons to the human cochaperone Sco1 (HSco1) in the oxidized state, i.e., with its metal-binding cysteines forming a disulfide bond.

Mouse (Murine) COX17 Cytochrome C Oxidase Assembly Homolog (S. Cerevisiae) (COX17) interaction partners

  1. Sp1, NRF-1 and NRF-2 are involved in basal transcription, similar to the transcription mechanism of other CCO-related genes

  2. cox17 has a role in activating cytochrome c (show CYCS Proteins) oxidase in mice

COX17 Protein Profile

Protein Summary

Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes a protein which is not a structural subunit, but may be involved in the recruitment of copper to mitochondria for incorporation into the COX apoenzyme. This protein shares 92% amino acid sequence identity with mouse and rat Cox17 proteins. This gene is no longer considered to be a candidate gene for COX deficiency. A pseudogene COX17P has been found on chromosome 13.

Gene names and symbols associated with COX17

  • cytochrome c oxidase copper chaperone (Tc00.1047053508153.994)
  • cytochrome c oxidase copper chaperone (Tb927.3.2650)
  • cytochrome c oxidase copper chaperone (PVX_111430)
  • COX17 cytochrome c oxidase assembly homolog (S. cerevisiae) (cox17)
  • COX17 cytochrome c oxidase assembly homolog (S. cerevisiae) (COX17)
  • COX17 homolog, cytochrome c oxidase assembly protein (yeast) (COX17)
  • COX17 cytochrome c oxidase assembly homolog (COX17)
  • COX17 cytochrome c oxidase copper chaperone (COX17)
  • COX17 cytochrome c oxidase copper chaperone (Cox17)
  • cytochrome c oxidase assembly protein 17 (Cox17)
  • AI037035 protein
  • COX17 protein
  • DKFZp469A2113 protein
  • Dopuin protein
  • Tb03.48O8.160 protein
  • zgc:103765 protein
  • zgc:191605 protein

Protein level used designations for COX17

cytochrome c oxidase copper chaperone , COX17 homolog, cytochrome c oxidase assembly protein , COX17 cytochrome c oxidase assembly homolog (S. cerevisiae) , COX17 homolog, cytochrome c oxidase assembly protein (yeast) , COX17 cytochrome c oxidase assembly homolog , cytochrome c oxidase 17 copper chaperone , cytochrome c oxidase assembly homolog 17 , human homolog of yeast mitochondrial copper recruitment , cytochrome c oxidase, subunit XVII assembly protein homolog , cytochrome c oxidase subunit XVII assembly protein homolog

GENE ID SPECIES
3555175 Trypanosoma cruzi strain CL Brener
3656200 Trypanosoma brucei brucei strain 927/4 GUTat10.1
5471293 Plasmodium vivax Sal-1
447914 Danio rerio
100172264 Pongo abelii
281708 Bos taurus
100156799 Sus scrofa
10063 Homo sapiens
89786 Rattus norvegicus
503668 Canis lupus familiaris
12856 Mus musculus
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