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Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Additionally we are shipping CRTC1 Proteins (6) and many more products for this protein.
Showing 10 out of 67 products:
Cow (Bovine) Polyclonal CRTC1 Primary Antibody for EIA, WB - ABIN401346
Coxon, Rozenblum, Park, Joshi, Tsurutani, Dennis, Kirsch, Kaye: Mect1-Maml2 fusion oncogene linked to the aberrant activation of cyclic AMP/CREB regulated genes. in Cancer research 2005
Show all 6 references for ABIN401346
Human Monoclonal CRTC1 Primary Antibody for ICC, FACS - ABIN969066
Winnes, Mölne, Suurküla, Andrén, Persson, Enlund, Stenman: Frequent fusion of the CRTC1 and MAML2 genes in clear cell variants of cutaneous hidradenomas. in Genes, chromosomes & cancer 2007
Show all 3 references for ABIN969066
Human Monoclonal CRTC1 Primary Antibody for EIA, FACS - ABIN1106839
Heinrich, Böer, Tzvetkov, Oetjen, Knepel: Stimulation by lithium of the interaction between the transcription factor CREB and its co-activator TORC. in Bioscience reports 2009
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Detection of the CRTC1/MAML2 (show MAML2 Antibodies) fusion transcript provides useful information for MEC (show CCL28 Antibodies) diagnosis but is not associated with differences in survival outcomes.
A specific CRTC1-MAMl2 (show MAML2 Antibodies)-induced transcriptional program was identified in mucoepidermoid carcinoma cells.
Translocation t(11;19)(q14-21;p12 (show POLE4 Antibodies)-13) in patients with Salivary mucoepidermoid carcinoma was reported , which results in fusion between exons 1 and 2 of CRTC1 on chromosome 19p13.
This study showed that CREB (show CREB1 Antibodies)-regulated transcriptional coactivator 1 (CRTC1) is required for HBV transcription and replication.
CRTC1 activation is a key event that drives the LKB1 (show STK11 Antibodies)-null mRNA signature in lung cancer. We also identified a positive feedback LKB1 (show STK11 Antibodies)/CRTC1 signaling loop for COX-2 (show COX2 Antibodies)/PGE2 regulation.
describe fundamental metabolic requirements of senescent primary human CD8 (show CD8A Antibodies)+ T cells and demonstrate that p38 MAPK (show MAPK14 Antibodies) blockade reverses senescence via an mTOR (show FRAP1 Antibodies)-independent pathway
Malignant mucoepidermoid salivary gland tumors can arise from a recurrent t (11, 19)(q21;p13.1) translocation that generates an unusual chimeric CRTC1/MAML2 (show MAML2 Antibodies) oncoprotein.
aberrantly activated AREG (show AREG Antibodies)-EGFR (show EGFR Antibodies) signaling is required for CRTC1-MAML2 (show MAML2 Antibodies)-positive MEC (show CCL28 Antibodies) cell growth and survival, suggesting that EGFR (show EGFR Antibodies)-targeted therapies will benefit patients with advanced, unresectable CRTC1-MAML2 (show MAML2 Antibodies)-positive MEC (show CCL28 Antibodies).
Lacrimal and salivary gland PAs and Ca-ex-PAs have similar genomic profiles and frequently overexpress the PLAG1 oncoprotein. Copy number gains involving 9p23-p22.3 (NFIB) and 22q12-qter (PDGFB) may be of importance for disease progression.
findings suggest that CRTC1 contributes to the genetics of human obesity in psychiatric patients and the general population.
This study demonstrates that TSC1 (show TSC1 Antibodies)- mechanistic target of rapamycin (show FRAP1 Antibodies) complex 1 (mTORC1) signaling contributes to the brown-to-white adipocyte phenotypic switch.[mTORC1]
These data identify Notch (show NOTCH1 Antibodies) as a therapeutically actionable branch point of metabolic signaling at which Akt (show AKT1 Antibodies) activation in the liver can be uncoupled from hepatosteatosis.[mTORC1]
aberrant mTORC1 signaling and impaired autophagy are consequences of the loss of Mtm1 (show MTM1 Antibodies) [mTORC1]
CRTC1 has a wide impact on CREB (show CREB1 Antibodies)-dpendent memory processes and fine-tunes CREB (show CREB1 Antibodies) output in a region-specific manner.
Translational activation of CREB (show CREB1 Antibodies) is caused by elevated phospho-elF2alpha (show EIF2S1 Antibodies).
PDK4 (show PDK4 Antibodies) promotes tumorigenesis through activation of the CREB (show CREB1 Antibodies)-RHEB (show RHEB Antibodies)-mTORC1 signaling cascade.
Our results reveal a critical role of Crtc1-dependent transcription on spatial memory formation and provide the first evidence that targeting brain transcriptome reverses memory loss in Alzheimer Disease.
Fisetin inhibits Akt (show AKT1 Antibodies)-mTORC1 signaling in 3T3-L1 preadipocytes and white adipose tissue in HFD-fed mice.
Report dose-dependent suppression of mTOR (show FRAP1 Antibodies) activity by IL-6 (show IL6 Antibodies) and suppressed mTOR (show FRAP1 Antibodies) responsiveness to glucose administration in Apc (show APC Antibodies)(Min/+) mice. IL-6 (show IL6 Antibodies) suppression of mTOR (show FRAP1 Antibodies) activity was dependent on AMPK (show PRKAA1 Antibodies) activation and independent of STAT (show STAT1 Antibodies) signaling in myotubes.
impaired expression and function of TORC1, which results in a reduction in PGC-1alpha (show PPARGC1A Antibodies), plays an important role in mitochondrial dysfunction in HD
Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR. Potent coactivator of PGC1alpha and inducer of mitochondrial biogenesis in muscle cells (By similarity). In the hippocampus, involved in late-phase long-term potentiation (L-LTP) maintenance at the Schaffer collateral-CA1 synapses. May be required for dendritic growth of developing cortical neurons.
CREB-regulated transcription coactivator 1
, mucoepidermoid carcinoma translocated 1
, CREB regulated transcription coactivator 1
, CREB-regulated transcription coactivator 1-like
, mucoepidermoid carcinoma translocated protein 1
, transducer of regulated cAMP response element-binding protein (CREB) 1
, mucoepidermoid carcinoma translocated protein 1 homolog
, transducer of CREB protein 1
, transducer of regulated cAMP response element-binding protein 1