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anti-CREB Regulated Transcription Coactivator 1 (CRTC1) Antibodies

Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Additionally we are shipping CRTC1 Proteins (6) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
CRTC1 23373 Q6UUV9
CRTC1 382056 Q68ED7
CRTC1 684527 Q157S1
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Top anti-CRTC1 Antibodies at antibodies-online.com

Showing 10 out of 71 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated EIA, WB 0.1 mg Log in to see 6 to 8 Days
$500.50
Details
Human Mouse Un-conjugated ICC, FACS, ELISA, WB Figure 1: Flow cytometric analysis of K562 cells using CRTC1 mouse mAb (green) and negative control (purple) . Figure 2: Immunofluorescence analysis of U251 (left) and NTERA2 (right) cells using CRTC1 mAb (green) . Red: Actin filaments have been labeled with DY-554 phalloidin. Blue: DRAQ5 fluorescent DNA dye. 100 μL Log in to see 3 to 4 Days
$393.80
Details
Human Mouse Un-conjugated ICC, FACS, IP, WB Western blot detection of TORC1(N-terminus) antibody in Hela and Jurkat lysates using TORC1(N-terminus) antibody (1: 1000 diluted).  Predicted band size: 69 kDa.  Observed band size: 69 kDa. Immunocytochemistry stain of Hela using TORC1 antibody (1: 300). 100 μL Log in to see 8 to 9 Days
$392.86
Details
Human Rabbit Un-conjugated ELISA, WB Western blot using affinity purified anti-MECT2 antibody shows detection of MECT2 (lower arrowhead) and MECT2:MAML2 fusion protein (top arrowhead) in cell lysates. Lane 1 contains lysate from cells expressing MECT2 only. Lane 2 contains lysate from cells transfected with fusion protein. Lane 3 contains lysate from cells strongly expressing MECT2 and weakly expressing the fusion protein. Lane 4 contains lysate from control cells. After SDS-PAGE and transfer, the membrane was probed with the primary antibody diluted to 1:1,000. 100 μg Log in to see 2 to 3 Days
$369.00
Details
Human Mouse Un-conjugated EIA, FACS, IF, WB 0.1 mL Log in to see 6 to 8 Days
$390.50
Details
Cow Rabbit Un-conjugated EIA, IF, IHC (p), WB 50 μg Log in to see 6 to 8 Days
$500.50
Details
Human Rabbit Un-conjugated WB Lane 3: Recombinant Human CRTC1 Protein 2.5ng 100 μg Log in to see 4 to 6 Days
$200.00
Details
Human Rabbit Un-conjugated IF (p), IHC (p), WB L1 rat brain, L2 human colon carcinoma lysates probed (ABIN746558) at 1:200 in 4 °C. Followed by conjugation to secondary antibody at 1:3000 90min in 37 °C. Predicted band and observed band size: 73kDa HeLa cells probed with Rabbit Anti-Torc1 (Ser151) Polyclonal Antibody . 100 μL Log in to see 3 to 7 Days
$291.50
Details
Human Mouse Un-conjugated ICC, WB 100 μL Log in to see 8 to 9 Days
$392.86
Details
Human Mouse Un-conjugated ICC, FACS, IF, IHC, ELISA, WB Human Liver, Hepatocytes: Formalin-Fixed, Paraffin-Embedded (FFPE) 50 μL Log in to see 8 to 10 Days
$451.00
Details

CRTC1 Antibodies by Reactivity, Application, Clonality and Conjugate

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Top referenced anti-CRTC1 Antibodies

  1. Cow (Bovine) Polyclonal CRTC1 Primary Antibody for EIA, WB - ABIN401346 : Coxon, Rozenblum, Park, Joshi, Tsurutani, Dennis, Kirsch, Kaye: Mect1-Maml2 fusion oncogene linked to the aberrant activation of cyclic AMP/CREB regulated genes. in Cancer research 2005 (PubMed)
    Show all 6 references for ABIN401346

  2. Human Monoclonal CRTC1 Primary Antibody for ICC, FACS - ABIN969066 : Winnes, Mölne, Suurküla, Andrén, Persson, Enlund, Stenman: Frequent fusion of the CRTC1 and MAML2 genes in clear cell variants of cutaneous hidradenomas. in Genes, chromosomes & cancer 2007 (PubMed)
    Show all 3 references for ABIN969066

  3. Human Monoclonal CRTC1 Primary Antibody for EIA, FACS - ABIN1106839 : Heinrich, Böer, Tzvetkov, Oetjen, Knepel: Stimulation by lithium of the interaction between the transcription factor CREB and its co-activator TORC. in Bioscience reports 2009 (PubMed)
    Show all 2 references for ABIN1106839

More Antibodies against CRTC1 Interaction Partners

Human CREB Regulated Transcription Coactivator 1 (CRTC1) interaction partners

  1. Detection of the CRTC1/MAML2 (show MAML2 Antibodies) fusion transcript provides useful information for MEC (show CCL28 Antibodies) diagnosis but is not associated with differences in survival outcomes.

  2. A specific CRTC1-MAMl2 (show MAML2 Antibodies)-induced transcriptional program was identified in mucoepidermoid carcinoma cells.

  3. Translocation t(11;19)(q14-21;p12 (show POLE4 Antibodies)-13) in patients with Salivary mucoepidermoid carcinoma was reported , which results in fusion between exons 1 and 2 of CRTC1 on chromosome 19p13.

  4. This study showed that CREB (show CREB1 Antibodies)-regulated transcriptional coactivator 1 (CRTC1) is required for HBV transcription and replication.

  5. CRTC1 activation is a key event that drives the LKB1 (show STK11 Antibodies)-null mRNA signature in lung cancer. We also identified a positive feedback LKB1 (show STK11 Antibodies)/CRTC1 signaling loop for COX-2 (show COX2 Antibodies)/PGE2 regulation.

  6. describe fundamental metabolic requirements of senescent primary human CD8 (show CD8A Antibodies)+ T cells and demonstrate that p38 MAPK (show MAPK14 Antibodies) blockade reverses senescence via an mTOR (show FRAP1 Antibodies)-independent pathway

  7. Malignant mucoepidermoid salivary gland tumors can arise from a recurrent t (11, 19)(q21;p13.1) translocation that generates an unusual chimeric CRTC1/MAML2 (show MAML2 Antibodies) oncoprotein.

  8. aberrantly activated AREG (show AREG Antibodies)-EGFR (show EGFR Antibodies) signaling is required for CRTC1-MAML2 (show MAML2 Antibodies)-positive MEC (show CCL28 Antibodies) cell growth and survival, suggesting that EGFR (show EGFR Antibodies)-targeted therapies will benefit patients with advanced, unresectable CRTC1-MAML2 (show MAML2 Antibodies)-positive MEC (show CCL28 Antibodies).

  9. Lacrimal and salivary gland PAs and Ca-ex-PAs have similar genomic profiles and frequently overexpress the PLAG1 oncoprotein. Copy number gains involving 9p23-p22.3 (NFIB) and 22q12-qter (PDGFB) may be of importance for disease progression.

  10. findings suggest that CRTC1 contributes to the genetics of human obesity in psychiatric patients and the general population.

Mouse (Murine) CREB Regulated Transcription Coactivator 1 (CRTC1) interaction partners

  1. This study demonstrates that TSC1 (show TSC1 Antibodies)- mechanistic target of rapamycin (show FRAP1 Antibodies) complex 1 (mTORC1) signaling contributes to the brown-to-white adipocyte phenotypic switch.[mTORC1]

  2. These data identify Notch (show NOTCH1 Antibodies) as a therapeutically actionable branch point of metabolic signaling at which Akt (show AKT1 Antibodies) activation in the liver can be uncoupled from hepatosteatosis.[mTORC1]

  3. aberrant mTORC1 signaling and impaired autophagy are consequences of the loss of Mtm1 (show MTM1 Antibodies) [mTORC1]

  4. CRTC1 has a wide impact on CREB (show CREB1 Antibodies)-dpendent memory processes and fine-tunes CREB (show CREB1 Antibodies) output in a region-specific manner.

  5. Translational activation of CREB (show CREB1 Antibodies) is caused by elevated phospho-elF2alpha (show EIF2S1 Antibodies).

  6. PDK4 (show PDK4 Antibodies) promotes tumorigenesis through activation of the CREB (show CREB1 Antibodies)-RHEB (show RHEB Antibodies)-mTORC1 signaling cascade.

  7. Our results reveal a critical role of Crtc1-dependent transcription on spatial memory formation and provide the first evidence that targeting brain transcriptome reverses memory loss in Alzheimer Disease.

  8. Fisetin inhibits Akt (show AKT1 Antibodies)-mTORC1 signaling in 3T3-L1 preadipocytes and white adipose tissue in HFD-fed mice.

  9. Report dose-dependent suppression of mTOR (show FRAP1 Antibodies) activity by IL-6 (show IL6 Antibodies) and suppressed mTOR (show FRAP1 Antibodies) responsiveness to glucose administration in Apc (show APC Antibodies)(Min/+) mice. IL-6 (show IL6 Antibodies) suppression of mTOR (show FRAP1 Antibodies) activity was dependent on AMPK (show PRKAA1 Antibodies) activation and independent of STAT (show STAT1 Antibodies) signaling in myotubes.

  10. impaired expression and function of TORC1, which results in a reduction in PGC-1alpha (show PPARGC1A Antibodies), plays an important role in mitochondrial dysfunction in HD

CRTC1 Antigen Profile

Protein Summary

Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR. Potent coactivator of PGC1alpha and inducer of mitochondrial biogenesis in muscle cells (By similarity). In the hippocampus, involved in late-phase long-term potentiation (L-LTP) maintenance at the Schaffer collateral-CA1 synapses. May be required for dendritic growth of developing cortical neurons.

Gene names and symbols associated with CRTC1

  • CREB regulated transcription coactivator 1 (CRTC1) antibody
  • CREB regulated transcription coactivator 1 (crtc1) antibody
  • CREB regulated transcription coactivator 1 (Crtc1) antibody
  • AI413414 antibody
  • CRTC1 antibody
  • Mect1 antibody
  • mKIAA0616 antibody
  • R74955 antibody
  • TORC-1 antibody
  • TORC1 antibody
  • WAMTP1 antibody

Protein level used designations for CRTC1

CREB-regulated transcription coactivator 1 , mucoepidermoid carcinoma translocated 1 , CREB regulated transcription coactivator 1 , CREB-regulated transcription coactivator 1-like , mucoepidermoid carcinoma translocated protein 1 , transducer of regulated cAMP response element-binding protein (CREB) 1 , TORC-1 , mucoepidermoid carcinoma translocated protein 1 homolog , transducer of CREB protein 1 , transducer of regulated cAMP response element-binding protein 1

GENE ID SPECIES
100523662 Sus scrofa
510465 Bos taurus
720274 Macaca mulatta
735806 Pan troglodytes
771015 Gallus gallus
100036611 Xenopus (Silurana) tropicalis
100385682 Callithrix jacchus
100479645 Ailuropoda melanoleuca
100548464 Meleagris gallopavo
23373 Homo sapiens
382056 Mus musculus
684527 Rattus norvegicus
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