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CREB Regulated Transcription Coactivator 1 Proteins (CRTC1)

Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Additionally we are shipping CRTC1 Antibodies (67) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
CRTC1 23373 Q6UUV9
CRTC1 382056 Q68ED7
CRTC1 684527 Q157S1
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Top CRTC1 Proteins at antibodies-online.com

Showing 5 out of 6 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$3,822.50
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

CRTC1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
,
Mouse (Murine)

Rat (Rattus)

More Proteins for CREB Regulated Transcription Coactivator 1 (CRTC1) Interaction Partners

Human CREB Regulated Transcription Coactivator 1 (CRTC1) interaction partners

  1. Detection of the CRTC1/MAML2 fusion transcript provides useful information for MEC (show CCL28 Proteins) diagnosis but is not associated with differences in survival outcomes.

  2. A specific CRTC1-MAMl2-induced transcriptional program was identified in mucoepidermoid carcinoma cells.

  3. Translocation t(11;19)(q14-21;p12 (show POLE4 Proteins)-13) in patients with Salivary mucoepidermoid carcinoma was reported , which results in fusion between exons 1 and 2 of CRTC1 on chromosome 19p13.

  4. This study showed that CREB (show CREB1 Proteins)-regulated transcriptional coactivator 1 (CRTC1) is required for HBV transcription and replication.

  5. CRTC1 activation is a key event that drives the LKB1 (show STK11 Proteins)-null mRNA signature in lung cancer. We also identified a positive feedback LKB1 (show STK11 Proteins)/CRTC1 signaling loop for COX-2/PGE2 regulation.

  6. describe fundamental metabolic requirements of senescent primary human CD8 (show CD8A Proteins)+ T cells and demonstrate that p38 MAPK (show MAPK14 Proteins) blockade reverses senescence via an mTOR (show FRAP1 Proteins)-independent pathway

  7. Malignant mucoepidermoid salivary gland tumors can arise from a recurrent t (11, 19)(q21;p13.1) translocation that generates an unusual chimeric CRTC1/MAML2 oncoprotein.

  8. aberrantly activated AREG (show AREG Proteins)-EGFR (show EGFR Proteins) signaling is required for CRTC1-MAML2-positive MEC (show CCL28 Proteins) cell growth and survival, suggesting that EGFR (show EGFR Proteins)-targeted therapies will benefit patients with advanced, unresectable CRTC1-MAML2-positive MEC (show CCL28 Proteins).

  9. Lacrimal and salivary gland PAs and Ca-ex-PAs have similar genomic profiles and frequently overexpress the PLAG1 oncoprotein. Copy number gains involving 9p23-p22.3 (NFIB) and 22q12-qter (PDGFB) may be of importance for disease progression.

  10. findings suggest that CRTC1 contributes to the genetics of human obesity in psychiatric patients and the general population.

Mouse (Murine) CREB Regulated Transcription Coactivator 1 (CRTC1) interaction partners

  1. This study demonstrates that TSC1 (show TSC1 Proteins)- mechanistic target of rapamycin (show FRAP1 Proteins) complex 1 (mTORC1) signaling contributes to the brown-to-white adipocyte phenotypic switch.[mTORC1]

  2. These data identify Notch (show NOTCH1 Proteins) as a therapeutically actionable branch point of metabolic signaling at which Akt (show AKT1 Proteins) activation in the liver can be uncoupled from hepatosteatosis.[mTORC1]

  3. aberrant mTORC1 signaling and impaired autophagy are consequences of the loss of Mtm1 (show MTM1 Proteins) [mTORC1]

  4. CRTC1 has a wide impact on CREB (show CREB1 Proteins)-dpendent memory processes and fine-tunes CREB (show CREB1 Proteins) output in a region-specific manner.

  5. Translational activation of CREB (show CREB1 Proteins) is caused by elevated phospho-elF2alpha (show EIF2S1 Proteins).

  6. PDK4 (show PDK4 Proteins) promotes tumorigenesis through activation of the CREB (show CREB1 Proteins)-RHEB (show RHEB Proteins)-mTORC1 signaling cascade.

  7. Our results reveal a critical role of Crtc1-dependent transcription on spatial memory formation and provide the first evidence that targeting brain transcriptome reverses memory loss in Alzheimer Disease.

  8. Fisetin inhibits Akt (show AKT1 Proteins)-mTORC1 signaling in 3T3-L1 preadipocytes and white adipose tissue in HFD-fed mice.

  9. Report dose-dependent suppression of mTOR (show FRAP1 Proteins) activity by IL-6 (show IL6 Proteins) and suppressed mTOR (show FRAP1 Proteins) responsiveness to glucose administration in Apc (show APC Proteins)(Min/+) mice. IL-6 (show IL6 Proteins) suppression of mTOR (show FRAP1 Proteins) activity was dependent on AMPK (show PRKAA1 Proteins) activation and independent of STAT (show STAT1 Proteins) signaling in myotubes.

  10. impaired expression and function of TORC1, which results in a reduction in PGC-1alpha, plays an important role in mitochondrial dysfunction in HD

CRTC1 Protein Profile

Protein Summary

Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR. Potent coactivator of PGC1alpha and inducer of mitochondrial biogenesis in muscle cells (By similarity). In the hippocampus, involved in late-phase long-term potentiation (L-LTP) maintenance at the Schaffer collateral-CA1 synapses. May be required for dendritic growth of developing cortical neurons.

Gene names and symbols associated with CRTC1

  • CREB regulated transcription coactivator 1 (CRTC1)
  • CREB regulated transcription coactivator 1 (crtc1)
  • CREB regulated transcription coactivator 1 (Crtc1)
  • AI413414 protein
  • CRTC1 protein
  • Mect1 protein
  • mKIAA0616 protein
  • R74955 protein
  • TORC-1 protein
  • TORC1 protein
  • WAMTP1 protein

Protein level used designations for CRTC1

CREB-regulated transcription coactivator 1 , mucoepidermoid carcinoma translocated 1 , CREB regulated transcription coactivator 1 , CREB-regulated transcription coactivator 1-like , mucoepidermoid carcinoma translocated protein 1 , transducer of regulated cAMP response element-binding protein (CREB) 1 , TORC-1 , mucoepidermoid carcinoma translocated protein 1 homolog , transducer of CREB protein 1 , transducer of regulated cAMP response element-binding protein 1

GENE ID SPECIES
100523662 Sus scrofa
510465 Bos taurus
720274 Macaca mulatta
735806 Pan troglodytes
771015 Gallus gallus
100036611 Xenopus (Silurana) tropicalis
100385682 Callithrix jacchus
100479645 Ailuropoda melanoleuca
100548464 Meleagris gallopavo
23373 Homo sapiens
382056 Mus musculus
684527 Rattus norvegicus
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