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Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Additionally we are shipping CRTC1 Antibodies (67) and many more products for this protein.
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Detection of the CRTC1/MAML2 fusion transcript provides useful information for MEC (show CCL28 Proteins) diagnosis but is not associated with differences in survival outcomes.
A specific CRTC1-MAMl2-induced transcriptional program was identified in mucoepidermoid carcinoma cells.
Translocation t(11;19)(q14-21;p12 (show POLE4 Proteins)-13) in patients with Salivary mucoepidermoid carcinoma was reported , which results in fusion between exons 1 and 2 of CRTC1 on chromosome 19p13.
This study showed that CREB (show CREB1 Proteins)-regulated transcriptional coactivator 1 (CRTC1) is required for HBV transcription and replication.
CRTC1 activation is a key event that drives the LKB1 (show STK11 Proteins)-null mRNA signature in lung cancer. We also identified a positive feedback LKB1 (show STK11 Proteins)/CRTC1 signaling loop for COX-2/PGE2 regulation.
describe fundamental metabolic requirements of senescent primary human CD8 (show CD8A Proteins)+ T cells and demonstrate that p38 MAPK (show MAPK14 Proteins) blockade reverses senescence via an mTOR (show FRAP1 Proteins)-independent pathway
Malignant mucoepidermoid salivary gland tumors can arise from a recurrent t (11, 19)(q21;p13.1) translocation that generates an unusual chimeric CRTC1/MAML2 oncoprotein.
aberrantly activated AREG (show AREG Proteins)-EGFR (show EGFR Proteins) signaling is required for CRTC1-MAML2-positive MEC (show CCL28 Proteins) cell growth and survival, suggesting that EGFR (show EGFR Proteins)-targeted therapies will benefit patients with advanced, unresectable CRTC1-MAML2-positive MEC (show CCL28 Proteins).
Lacrimal and salivary gland PAs and Ca-ex-PAs have similar genomic profiles and frequently overexpress the PLAG1 oncoprotein. Copy number gains involving 9p23-p22.3 (NFIB) and 22q12-qter (PDGFB) may be of importance for disease progression.
findings suggest that CRTC1 contributes to the genetics of human obesity in psychiatric patients and the general population.
This study demonstrates that TSC1 (show TSC1 Proteins)- mechanistic target of rapamycin (show FRAP1 Proteins) complex 1 (mTORC1) signaling contributes to the brown-to-white adipocyte phenotypic switch.[mTORC1]
These data identify Notch (show NOTCH1 Proteins) as a therapeutically actionable branch point of metabolic signaling at which Akt (show AKT1 Proteins) activation in the liver can be uncoupled from hepatosteatosis.[mTORC1]
aberrant mTORC1 signaling and impaired autophagy are consequences of the loss of Mtm1 (show MTM1 Proteins) [mTORC1]
CRTC1 has a wide impact on CREB (show CREB1 Proteins)-dpendent memory processes and fine-tunes CREB (show CREB1 Proteins) output in a region-specific manner.
Translational activation of CREB (show CREB1 Proteins) is caused by elevated phospho-elF2alpha (show EIF2S1 Proteins).
PDK4 (show PDK4 Proteins) promotes tumorigenesis through activation of the CREB (show CREB1 Proteins)-RHEB (show RHEB Proteins)-mTORC1 signaling cascade.
Our results reveal a critical role of Crtc1-dependent transcription on spatial memory formation and provide the first evidence that targeting brain transcriptome reverses memory loss in Alzheimer Disease.
Fisetin inhibits Akt (show AKT1 Proteins)-mTORC1 signaling in 3T3-L1 preadipocytes and white adipose tissue in HFD-fed mice.
Report dose-dependent suppression of mTOR (show FRAP1 Proteins) activity by IL-6 (show IL6 Proteins) and suppressed mTOR (show FRAP1 Proteins) responsiveness to glucose administration in Apc (show APC Proteins)(Min/+) mice. IL-6 (show IL6 Proteins) suppression of mTOR (show FRAP1 Proteins) activity was dependent on AMPK (show PRKAA1 Proteins) activation and independent of STAT (show STAT1 Proteins) signaling in myotubes.
impaired expression and function of TORC1, which results in a reduction in PGC-1alpha, plays an important role in mitochondrial dysfunction in HD
Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR. Potent coactivator of PGC1alpha and inducer of mitochondrial biogenesis in muscle cells (By similarity). In the hippocampus, involved in late-phase long-term potentiation (L-LTP) maintenance at the Schaffer collateral-CA1 synapses. May be required for dendritic growth of developing cortical neurons.
CREB-regulated transcription coactivator 1
, mucoepidermoid carcinoma translocated 1
, CREB regulated transcription coactivator 1
, CREB-regulated transcription coactivator 1-like
, mucoepidermoid carcinoma translocated protein 1
, transducer of regulated cAMP response element-binding protein (CREB) 1
, mucoepidermoid carcinoma translocated protein 1 homolog
, transducer of CREB protein 1
, transducer of regulated cAMP response element-binding protein 1