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CTD (Carboxy-terminal Domain, RNA Polymerase II, Polypeptide A) Phosphatase, Subunit 1 Proteins (CTDP1)

CTDP1 encodes a protein which interacts with the carboxy-terminus of the RAP74 subunit of transcription initiation factor TFIIF, and functions as a phosphatase that processively dephosphorylates the C-terminus of POLR2A (a subunit of RNA polymerase II), making it available for initiation of gene expression. Additionally we are shipping CTDP1 Antibodies (36) and CTDP1 Kits (2) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
Rat CTDP1 CTDP1 291414  
CTDP1 9150 Q9Y5B0
CTDP1 67655 Q7TSG2
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Top CTDP1 Proteins at antibodies-online.com

Showing 4 out of 4 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Encephalitozoon cuniculi His tag   1 mg Log in to see 56 to 66 Days
$3,142.33
Details

CTDP1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
,
Mouse (Murine)

More Proteins for CTD (Carboxy-terminal Domain, RNA Polymerase II, Polypeptide A) Phosphatase, Subunit 1 (CTDP1) Interaction Partners

Human CTD (Carboxy-terminal Domain, RNA Polymerase II, Polypeptide A) Phosphatase, Subunit 1 (CTDP1) interaction partners

  1. results demonstrated that CTDP1 was upregulated in human lung cancer tissues. In addition, it implied that CTDP1 played an important role in cell proliferation and may be a useful therapeutic target in human lung cancer.

  2. Data propose that Fcp1 has a crucial role in the liaison between dephosphorylation and ubiquitination that drives mitosis exit.

  3. although FCP1 is intrinsically disordered, the above 16 residues composing the RAP74 (show GTF2F1 Proteins) binding surface form nascent alpha-helical structure in the unbound state.

  4. FCP1 augments tat (show TAT Proteins) transactivation of the HIV-1 long-terminal repeat

  5. FCP1 is important for transcription elongation along with TFIIF (show GTF2F1 Proteins)

  6. FCP1 binds to a groove of RAP74 (show GTF2F1 Proteins) between alpha-helices H2 and H3, without affecting the secondary structure of RAP74 (show GTF2F1 Proteins) C-terminal domain; FCP1 binds also to a groove of TFIIB (show GTF2B Proteins) core domain beween alpha helices D1 and E1 in the first cyclin (show PCNA Proteins) repeat.

  7. FCP1 kinase from HeLa cells is phosphorylated and affects transcription elongation

  8. cocrystal structure of the winged-helix domain of human RNA polymerase II-associating protein 74 bound to the alpha-helical C terminus of human FCP1

  9. Congenital cataracts facial dysmorphism neuropathy is caused by a single-nucleotide substitution in an antisense Alu element in intron 6 of CTDP1, resulting in a rare mechanism of aberrant splicing and an Alu insertion in the processed mRNA

  10. found that FCP1 is a genuine substrate of PRMT5 (show PRMT5 Proteins)-methylation both in vivo and in vitro, and FCP1-associated PRMT5 (show PRMT5 Proteins) can methylate histones H4 in vitro

CTDP1 Protein Profile

Protein Summary

This gene encodes a protein which interacts with the carboxy-terminus of the RAP74 subunit of transcription initiation factor TFIIF, and functions as a phosphatase that processively dephosphorylates the C-terminus of POLR2A (a subunit of RNA polymerase II), making it available for initiation of gene expression. Mutations in this gene are associated with congenital cataracts, facial dysmorphism and neuropathy syndrome (CCFDN). Alternatively spliced transcript variants encoding different isoforms have been described for this gene.

Gene names and symbols associated with CTDP1

  • CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1 (Ctdp1)
  • CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1 (CTDP1)
  • CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1 (ctdp1)
  • RNA polymerase II subunit A C-terminal domain phosphatase (ANI_1_2668024)
  • RNA polymerase II subunit A C-terminal domain phosphatase (AOR_1_1228154)
  • RNA polymerase II subunit A C-terminal domain phosphatase (CpipJ_CPIJ004583)
  • RNA polymerase II subunit A C-terminal domain phosphatase (PTRG_11566)
  • RNA polymerase II subunit A C-terminal domain phosphatase (SJAG_01286)
  • RNA polymerase II subunit A C-terminal domain phosphatase (MCYG_05528)
  • RNA polymerase II subunit A C-terminal domain phosphatase (VDBG_09811)
  • CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1 (LOC100222208)
  • 4930563P03Rik protein
  • AW553592 protein
  • CCFDN protein
  • CTDP1 protein
  • FCP1 protein

Protein level used designations for CTDP1

RNA polymerase II subunit A C-terminal domain phosphatase , CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1 , RNA polymerase II subunit A C-terminal domain phosphatase-like , CTD of POLR2A, phosphatase of, subunit 1 , TFIIF-associating CTD phosphatase 1 , serine phosphatase FCP1a , transcription factor IIF-associating CTD phosphatase 1 , CTD (carboxy-terminal domina, RNA polymerase II, polypeptide A) phosphatase, subunit 1 , TFIIF-associating CTD phosphatase

GENE ID SPECIES
291414 Rattus norvegicus
420813 Gallus gallus
442930 Danio rerio
468592 Pan troglodytes
476158 Canis lupus familiaris
519011 Bos taurus
698467 Macaca mulatta
4979212 Aspergillus niger CBS 513.88
5991827 Aspergillus oryzae RIB40
6036281 Culex quinquefasciatus
6349883 Pyrenophora tritici-repentis Pt-1C-BFP
7052361 Schizosaccharomyces japonicus yFS275
9224666 Arthroderma otae CBS 113480
9528922 Verticillium alfalfae VaMs.102
100065422 Equus caballus
100158188 Sus scrofa
100222208 Taeniopygia guttata
100405913 Callithrix jacchus
9150 Homo sapiens
67655 Mus musculus
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