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CTC1 encodes a component of the CST complex. Additionally we are shipping and many more products for this protein.
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POT1a promotes an extendable telomere state via contacts with the telomerase RNP as well as STN1 and CTC1, while TEN1 opposes these functions.
findings indicate that ATR and CST (CTC1/STN1/TEN1) act synergistically to maintain genome integrity and telomere length homeostasis
CTC1 participates in telomere maintenance in diverse species and that a CST (show GAL3ST1 Antibodies)-like complex is required for telomere integrity in multicellular organisms. [CTC1]
HBV DNAPTP1 (show FAM120A Antibodies) downregulated the expression of SWI5 and CTC1 at translation level.
Coats plus syndrome also known as cerebroretinal microangiopathy with calcifications and cysts, is an autosomal recessive pleomorphic disorder caused by the CTS telomere maintenance complex component 1 gene.
CTC1 gene screening confirmed the diagnosis of cerebro-retinal microangiopathy with calcifications and cysts with the identification of heterozygous deleterious mutations
we explored two SNPs in genes associated either with telomere biology (OBFC1 (show OBFC1 Antibodies)) or with LTL (OBCF1 and CTC1). Interestingly, we observed that genetic variation does not account for LTL at birth
an Indian family links Coats plus syndrome and dextrocardia with a homozygous novel CTC1 and a rare HES7 (show HES7 Antibodies) variation
The mammalian CST (show GAL3ST1 Antibodies) (CTC1-STN1 (show STON1 Antibodies)-TEN1) complex is directly involved at several stages of telomere end formation and CST (show GAL3ST1 Antibodies) seems to play critical roles in coordinating telomerase elongation and fill-in synthesis to complete telomere replication.
CTC1 mutations promote telomere dysfunction by decreasing the stability of STN1 to reduce its ability to interact with DNA Polalpha, thus highlighting a previously unknown mechanism to induce telomere dysfunction.
identify CTC1 disease mutations that disrupt CST complex formation, the physical interaction with DNA polymerase alpha-primase (polalpha-primase), telomeric ssDNA binding in vitro, accumulation in the nucleus, and/or telomere association in vivo
Genome-wide meta-analysis points to CTC1 and ZNF676 (show ZNF676 Antibodies) as genes regulating telomere homeostasis in humans.
CTC1-STN1-TEN1 complex rescues stalled replication forks during conditions of replication stress, such as those found at natural replication barriers, likely by facilitating dormant origin firing
These data demonstrate an essential role for CTC1 in promoting efficient replication and length maintenance of telomeres.
This gene encodes a component of the CST complex. This complex plays an essential role in protecting telomeres from degradation. This protein also forms a heterodimer with the CST complex subunit STN1 to form the enzyme alpha accessory factor. This enzyme regulates DNA replication. Mutations in this gene are the cause of cerebroretinal microangiopathy with calcifications and cysts. Alternate splicing results in both coding and non-coding variants.
CST complex subunit CTC1
, HBV DNAPTP1-transactivated protein B
, alpha accessory factor 132
, conserved telomere capping protein 1
, alpha-accessory factor of 132 kDa
, conserved telomere maintenance component 1