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Natural killer (NK) cells express multiple calcium-dependent (C-type) lectin-like receptors, such as CD94 (KLRD1; MIM 602894) and NKG2D (KLRC4; MIM 602893), that interact with major histocompatibility complex class I molecules and either inhibit or activa. Additionally we are shipping C-Type Lectin Domain Family 1, Member B Proteins (10) and C-Type Lectin Domain Family 1, Member B Kits (1) and many more products for this protein.
Showing 10 out of 124 products:
Mouse (Murine) Monoclonal CLEC1B Primary Antibody for ICFC - ABIN2662694
Acton, Astarita, Malhotra, Lukacs-Kornek, Franz, Hess, Jakus, Kuligowski, Fletcher, Elpek, Bellemare-Pelletier, Sceats, Reynoso, Gonzalez, Graham, Chang, Peters, Woodruff, Kim, Swat, Morita, Kuchroo et al.: Podoplanin-rich stromal networks induce dendritic cell motility via activation of the C-type lectin receptor CLEC-2. ... in Immunity 2012
Show all 6 references for 2662694
Mouse (Murine) Monoclonal CLEC1B Primary Antibody for FACS - ABIN2473005
de Lacey, McCabe, Constant, Welch, Spinks, McNally: Testing a policy for skull radiography (and admission) following mild head injury. in The British journal of radiology 1990
Show all 3 references for 2473005
Human Polyclonal CLEC1B Primary Antibody for ELISA, WB - ABIN408714
Suzuki-Inoue, Kato, Inoue, Kaneko, Mishima, Yatomi, Yamazaki, Narimatsu, Ozaki: Involvement of the snake toxin receptor CLEC-2, in podoplanin-mediated platelet activation, by cancer cells. in The Journal of biological chemistry 2007
Human Monoclonal CLEC1B Primary Antibody for IP, ELISA - ABIN526588
Manne, Badolia, Dangelmaier, Kunapuli: C-type lectin like receptor 2 (CLEC-2) signals independently of lipid raft microdomains in platelets. in Biochemical pharmacology 2015
NZ-1 inhibits the hPDPN-CLEC-2 interaction and is also useful for anti-PA tag MAb.The minimum epitope of LpMab-13 was identified as Ala42-Asp49 of hPDPN using Western blot and flow cytometry. The combination of different epitope-possessing MAbs could be advantageous for the hPDPN-targeting diagnosis and therapy
CLEC2 prevents expression of PI3K (show PIK3CA Antibodies) subunits, in a SYK (show SYK Antibodies)-dependent manner, to suppress the invasive activities of gastric cancer cells.
CLEC-2 regulates Akt and MAPK downstream of PI3K and PKC, leading to phosphorylation and inhibition of GSK3alpha/beta, and enhanced platelet aggregation and secretion.
Data (including data from studies using recombinant proteins) suggest that a diverse range of ligands activate platelets through activation/phosphorylation (show CD36 Antibodies) of C (show GP6 Antibodies)D36/GPVI (glycoprotein VI) and/or CLEC-2 (C-type lectin-like receptor-2).
PI3K (show PIK3CA Antibodies) and Tec (show NR4A3 Antibodies) family kinases play a crucial role in the regulation of platelet activation and Syk (show SYK Antibodies) phosphorylation downstream of the CLEC-2 receptor
fucoidan is a novel CLEC-2 receptor agonist that activates platelets through a SFK-dependent signaling pathway
Dimerization of two phosphorylated CLEC-2 molecules leads to recruitment of the tyrosine kinase Syk via its tandem SH2 domains and initiation of a downstream signaling cascade
A differential proteomic analysis of basal and rhodocytin-activated platelets with the aim of providing novel clues on CLEC-2 signaling regulation.
The glycosylation sites (N120 and N134) are necessary for the surface expression of CLEC-2.
Shedding of CLEC-2 from the cell surface may reflect increased expression of this membrane protein and serve as a marker of disease activity.
a novel mechanism of Deep vein thrombosis, whereby CLEC-2 and upregulation of podoplanin (show PDPN Antibodies) expression in the venous wall trigger thrombus formation
A reciprocal interaction between CLEC-2 on megakaryocytes and PDPN (show PDPN Antibodies) on Bone marrow (BM) Fibroblastic reticular cell-like cells contributes to the periarteriolar megakaryopoietic microenvironment in mouse BM.
A role for CLEC2 as a regulator of macrophage polarity and Kupffer cell polarity, lipid and glucose homeostasis
Data indicate that C-type lectin-like receptor-2 (CLEC-2) is highly expressed on bone marrow megakaryocytes (Mks (show MKKS Antibodies)).
Data (including data from studies in transgenic mice) suggest that a diverse range of ligands activate platelets through activation/phosphorylation of Cd36 (show CD36 Antibodies)/GPVI (show GP6 Antibodies) (glycoprotein VI) and/or Clec-2 (C-type lectin-like receptor-2).
Podoplanin (show PDPN Antibodies) and CLEC-2 critically drive the formation and integrity of developing cerebral blood vessels.
PI3K and Tec (show NR4A3 Antibodies) family kinases play a crucial role in the regulation of platelet activation and Syk (show SYK Antibodies) phosphorylation downstream of the CLEC-2 receptor
CLEC-2 signaling promotes adhesion to Podoplanin (show PDPN Antibodies) and regulation of Podoplanin (show PDPN Antibodies) signaling, thereby contributing to lymphatic vasculature development.
Under resting conditions, when FRCs are unlikely to encounter mature DCs expressing the PDPN (show PDPN Antibodies) receptor CLEC-2, PDPN (show PDPN Antibodies) endowed FRCs with contractile function and exerted tension within the reticulum.
Functional studies of platelets from Ceacam2 (show CEACAM2 Antibodies)(-/-)-deficient mice (Cc2 (show TSG101 Antibodies)(-/-)) revealed that CEACAM2 (show CEACAM2 Antibodies) serves to negatively regulate collagen glycoprotein VI (platelet) (GPVI (show GP6 Antibodies))-FcRgamma (show FCER1G Antibodies)-chain and the C-type lectinlike receptor 2 (CLEC-2) signaling
Natural killer (NK) cells express multiple calcium-dependent (C-type) lectin-like receptors, such as CD94 (KLRD1\; MIM 602894) and NKG2D (KLRC4\; MIM 602893), that interact with major histocompatibility complex class I molecules and either inhibit or activate cytotoxicity and cytokine secretion. CLEC2 is a C-type lectin-like receptor expressed in myeloid cells and NK cells (Colonna et al., 2000
C-type lectin domain family 1, member B
, C-type lectin domain family 1 member B
, c-type lectin domain family 1 member B-like
, C-type lectin-like receptor 2
, C-type lectin-like receptor-2