C-Type Lectin Domain Family 4, Member E Proteins (CLEC4E)

CLEC4E encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Additionally we are shipping CLEC4E Antibodies (63) and CLEC4E Kits (16) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
CLEC4E 26253 Q9ULY5
CLEC4E 56619 Q9R0Q8
Rat CLEC4E CLEC4E 450223 Q67EQ1
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Top CLEC4E Proteins at antibodies-online.com

Showing 8 out of 11 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
$5,442.50
Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 50 to 55 Days
$4,244.78
Details
HOST_Human Cells Rhesus Monkey Fc Tag,ECD 50 μg Log in to see 20 to 21 Days
$547.80
Details
HOST_HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see 10 to 12 Days
$785.40
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HOST_Mammalian Cells Human His tag   50 μg Log in to see 4 Days
$385.00
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HOST_Human Human His tag   10 μg Log in to see 15 to 16 Days
$225.00
Details
HOST_Escherichia coli (E. coli) Human His tag   100 μg Log in to see 2 to 3 Days
$418.88
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$405.71
Details

CLEC4E Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , , , ,
, , ,
Mouse (Murine)
,

Top referenced CLEC4E Proteins

  1. Human CLEC4E Protein expressed in HEK-293 Cells - ABIN2712869 : Wevers, Kaptein, Zijlstra-Willems, Theelen, Boekhout, Geijtenbeek, Gringhuis: Fungal engagement of the C-type lectin mincle suppresses dectin-1-induced antifungal immunity. in Cell host & microbe 2014 (PubMed)

More Proteins for C-Type Lectin Domain Family 4, Member E (CLEC4E) Interaction Partners

Human C-Type Lectin Domain Family 4, Member E (CLEC4E) interaction partners

  1. combination adjuvant systems demonstrate markedly different immune activation with age, with combined DC activation via Macrophage-inducible C-type lectin and TLR7 (show TLR7 Proteins)/8 representing a novel approach to enhance the efficacy of early-life vaccines.

  2. We here show that Mincle gene expression was induced in alveolar macrophages and neutrophils in bronchoalveolar lavage fluids of mice and patients with pneumococcal pneumonia

  3. a nonredundant role for Clec4e in coordinating major biological pathways involved in atherosclerosis

  4. CLEC4E expression is significantly upregulated in human masticatory mucosa during wound healing

  5. The expression of Mincle increases significantly during the early period of Aspergillus fumigatus infection, while expression of eight corresponding cytokines changes. Mincle, as a pattern recognition receptor, may play a role in the early innate immune response of the corneal resistance against fungus.

  6. Induction of Mincle by Helicobacter pylori and consequent anti-inflammatory signaling denote a bacterial survival strategy.

  7. our findings identify mincle as a contributor to the inflammatory response after traumatic brain injury

  8. Data indicate that MINCLE receptor is able to mediate the response to trehalose-6,6-dimycolate (TDM) dependent on SYK (show SYK Proteins) kinase and CARD9 (show CARD9 Proteins) protein.

  9. mincle is a fungal receptor that can suppress antifungal immunity and, as such, is a potential therapeutic target.

  10. These results demonstrated that GroMM is a unique ligand for human Mincle that is not recognized by mouse Mincle.

Mouse (Murine) C-Type Lectin Domain Family 4, Member E (CLEC4E) interaction partners

  1. Mincle is induced specifically on M1 macrophages, where Mincle-Syk (show SYK Proteins) signaling promotes and maintains inflammatory phenotypes of M1 macrophages in acute renal inflammation.

  2. work implicates a novel innate immune driver of Con (show KITLG Proteins) A hepatitis and, more broadly, suggests a potential role for Mincle in diseases governed by sterile inflammation.

  3. Mincle deletion results in TLR4 (show TLR4 Proteins)-mediated inflammation.

  4. Priming by Mincle-deficient dendritic cells (DCs).

  5. Thus, macrophage activation by the corynebacterial cell wall relies on TLR2-driven robust Mincle expression and the cooperative action of both receptors.

  6. this study shows that immune activation in vitro and in vivo by trehalose esters of simple fatty acids requires two acyl chains of length and involves Mincle

  7. Attenuated neutrophil extracellular trap formation in Mincle-/- neutrophils correlates with impaired autophagy activation in vitro and in vivo, whereas reactive oxygen species formation in these neutrophils remained intact.

  8. We here show that Mincle gene expression was induced in alveolar macrophages and neutrophils in bronchoalveolar lavage fluids of mice and patients with pneumococcal pneumonia

  9. this study shows a significant role for Mincle in Pneumocystis modulating host defense during infection

  10. The authors report that microbial stimulation triggers Mincle (Clec4e) expression through the myeloid differentiation primary response gene 88 (MyD88 (show MYD88 Proteins)) pathway; a process that does not require MCL (Clecsf8 (show CLEC4D Proteins), Clec4d (show CLEC4D Proteins)). Conversely, they show that MCL (show CLEC4D Proteins) is constitutively expressed but retained intracellularly until Mincle is induced, whereupon the receptors form heterodimers which are translocated to the cell surface.

Cow (Bovine) C-Type Lectin Domain Family 4, Member E (CLEC4E) interaction partners

  1. The structure of an extended portion of the extracellular domain of mincle, beyond the minimal C-type carbohydrate recognition domain, also constrains the way the binding domains may interact on the surface of macrophages.

  2. The data demonstrate how mincle bridges between the surfaces of the macrophage and the mycobacterium.

Guinea Pig C-Type Lectin Domain Family 4, Member E (CLEC4E) interaction partners

  1. the function of the guinea pig homologue of Mincle (gpMincle) and MCL (show CLEC4D Proteins) (gpMCL). gpMincle directly bound to trehalose-6,6'-dimycolate

CLEC4E Protein Profile

Protein Summary

This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response. The encoded type II transmembrane protein is a downstream target of CCAAT/enhancer binding protein (C/EBP), beta (CEBPB) and may play a role in inflammation. Alternative splice variants have been described but their full-length sequence has not been determined. This gene is closely linked to other CTL/CTLD superfamily members on chromosome 12p13 in the natural killer gene complex region.

Gene names and symbols associated with CLEC4E

  • C-type lectin domain family 4, member E (CLEC4E)
  • C-type lectin domain family 4, member e (Clec4e)
  • C-type lectin domain family 4, member E (Clec4e)
  • C-type lectin domain family 4, member E (LOC100350649)
  • C86253 protein
  • CLEC4E protein
  • Clecsf9 protein
  • Mincle protein

Protein level used designations for CLEC4E

C-type lectin domain family 4, member E , C-type (calcium dependent, carbohydrate-recognition domain) lectin, superfamily member 9 , C-type lectin domain family 4 member E , C-type lectin superfamily member 9 , macrophage-inducible C-type lectin , C-type (calcium dependent, carbohydrate recognition domain) lectin, superfamily member 9 , C-type lectin, superfamily member 9 , immunoreceptor

GENE ID SPECIES
611538 Canis lupus familiaris
722250 Macaca mulatta
735637 Pan troglodytes
100135686 Ovis aries
26253 Homo sapiens
56619 Mus musculus
450223 Rattus norvegicus
514797 Bos taurus
100350649 Oryctolagus cuniculus
100726838 Cavia porcellus
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