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The protein encoded by CDCP1 is a transmembrane protein containing three extracellular CUB domains. Additionally we are shipping CUB Domain Containing Protein 1 Antibodies (141) and CUB Domain Containing Protein 1 Proteins (15) and many more products for this protein.
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Elevated CDCP1 was observed in 77% of HGSC cases. Silencing of CDCP1 reduced migration and non-adherent cell growth in vitro and tumour burden in vivo.
CDCP1 protein plays an important role in the progression of ovarian clear cell carcinoma. Elevated CDCP1 levels correlates with poor patient outcome in ovarian clear cell carcinoma patients.
CDCP1 overexpression enhances HER2 (show ERBB2 ELISA Kits) activity. CDCP1 binds to HER2 (show ERBB2 ELISA Kits), promoting SRC (show SRC ELISA Kits)-HER2 (show ERBB2 ELISA Kits) crosstalk.
Multiple tyrosine phosphorylation sites of CDCP1 are important for the functional regulation of SFKs in several tumor types.
These data suggest CDCP1 expression can be used to identify a subset of marrow fibroblasts functionally distinct from CD146 (show MCAM ELISA Kits)+ fibroblasts.
The aim of this study was to examine whether activation of Trask may be potentially important in brain metastasis of lung cancers, the commonest site of organ spread and producing the deadliest consequences.
decreased CDCP1 expression promoted the invasive and migratory abilities of esophageal cancer cell lines.
CDCP1 protein induced by oncogenic Ras/Erk signaling is essential for Ras-mediated metastatic potential of cancer cells.
CDCP1 modulates cell-substratum adhesion and motility in colon cancer cell lines.
EGF (show EGF ELISA Kits) increases the lifespan of CDCP1 promoting its availability on the cell surface where the data indicate it is available to mediate procancer phenotypes such as cell migration.
Trask loss enhances tumorigenic growth by liberating integrin signaling and growth factor receptor (show RYK ELISA Kits) cross-talk in unanchored cells.
established mechanism for initiation of CDCP1-mediated signaling; demonstrated that processing of surface CDCP1 by extracellular serine proteases is prerequisite for CDCP1-dependent survival of cancer cells during metastasis; preventing cleavage of CDCP1 abrogated survival signaling associated with CDCP1 and induced PARP1 (show PARP1 ELISA Kits) cleavage and PARP1 (show PARP1 ELISA Kits)-mediated apoptosis
CDCP1 may have a role in neoplasm metastasis; targeting it with a monoclonal antibody inhibits metastasis in a prostate cancer model
The protein encoded by this gene is a transmembrane protein containing three extracellular CUB domains. This protein is found to be overexpressed in colon and lung cancers. Its expression level is correlated with the metastatic ability of carcinoma cells. This protein is located on the cell surface. It has been shown to be tyrosine phosphorylated in a cancer cell line. Alternatively spliced transcript variants encoding distinct isoforms have been reported.
CUB domain-containing protein 1
, membrane glycoprotein gp140
, subtractive immunization M plus HEp3-associated 135 kDa protein
, transmembrane and associated with src kinases