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Controls PGR and ESR1 protein levels through their targeting for ubiquitination and subsequent proteasomal degradation (By similarity).. Additionally we are shipping CUEDC2 Proteins (8) and CUEDC2 Kits (4) and many more products for this protein.
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Human Polyclonal CUEDC2 Primary Antibody for EIA, IF - ABIN499688
Ponting: Proteins of the endoplasmic-reticulum-associated degradation pathway: domain detection and function prediction. in The Biochemical journal 2001
Show all 4 references for ABIN499688
Human Polyclonal CUEDC2 Primary Antibody for ICC, ELISA - ABIN1030352
Chen, Wang, Mu, Luo, Liu, Liang, Zhuo, Hao, Wang, Fang, Bai, Wang, Wang, Jin, Gong, Zhou, Zhang, Xia, Li: Dysregulation of the MiR-324-5p-CUEDC2 Axis Leads to Macrophage Dysfunction and Is Associated with Colon Cancer. in Cell reports 2014
Human Polyclonal CUEDC2 Primary Antibody for EIA, WB - ABIN452895
Grupe, Li, Rowland, Nowotny, Hinrichs, Smemo, Kauwe, Maxwell, Cherny, Doil, Tacey, van Luchene, Myers, Wavrant-De Vrièze, Kaleem, Hollingworth, Jehu, Foy, Archer, Hamilton, Holmans, Morris, Catanese et al.: A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. ... in American journal of human genetics 2005
Human Polyclonal CUEDC2 Primary Antibody for WB - ABIN871773
Zhang, Zhao, Li, Man, He, Zhou, Pan, Li, Gong, Jin, Xia, Yu, Shen, Zhang: CUE domain containing 2 regulates degradation of progesterone receptor by ubiquitin-proteasome. in The EMBO journal 2007
Results suggest that decreased expression of CUEDC2 contributes to tumor growth in lung adenocarcinoma, leading to a poor clinical outcome.
CUEDC2 plays a crucial role in modulating macrophage function and is associated with both colitis and colon tumorigenesis.
High CUEDC2 sensitizes chronic myeloid leukemic cells to imatinib treatment.
In response to UV irradiation, CUEDC2 undergoes ERK1/2 (show MAPK1/3 Antibodies)-dependent phosphorylation and ubiquitin-dependent degradation, leading to APC (show APC Antibodies)/C(Cdh1 (show CDH1 Antibodies))-mediated cyclin A (show CCNA2 Antibodies) destruction, cyclin-dependent kinase 2 (show KKIAMRE Antibodies) inactivation, and G1 arrest.
a new biological activity for CUEDC2 as the regulator of JAK1 (show JAK1 Antibodies)/STAT3 (show STAT3 Antibodies) signaling and the mechanism by which SOCS3 (show SOCS3 Antibodies) has been linked to suppression of the JAK (show JAK3 Antibodies)/STAT (show STAT1 Antibodies) pathway
CUEDC2 is a cell-cycle regulator (show CDKN2A Antibodies) that promotes spindle checkpoint inactivation and releases APC (show APC Antibodies)/C from checkpoint inhibition. CUEDC2 is phosphorylated by Cdk1 (show CDK1 Antibodies) during mitosis.
These results identify a key post-translational mechanism that controls progesterone receptor (show PGR Antibodies) protein levels and for the first time provide an important insight into the function of CUEDC2 in breast cancer proliferation.
These findings demonstrate that CUEDC2 plays an important role in protection from colonic inflammation, primarily by inhibiting the NF-kappaB (show NFKB1 Antibodies) and STAT3 (show STAT3 Antibodies) signaling pathways and preventing excessive proliferation of the inflammatory epithelial cell.
Controls PGR and ESR1 protein levels through their targeting for ubiquitination and subsequent proteasomal degradation (By similarity).
CUE domain-containing protein 2-A
, mitotic phosphoprotein 38
, CUE domain containing 2
, CUE domain-containing protein 2-B
, CUE domain-containing protein 2