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Controls PGR and ESR1 protein levels through their targeting for ubiquitination and subsequent proteasomal degradation (By similarity).. Additionally we are shipping CUEDC2 Antibodies (78) and CUEDC2 Proteins (8) and many more products for this protein.
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Results suggest that decreased expression of CUEDC2 contributes to tumor growth in lung adenocarcinoma, leading to a poor clinical outcome.
CUEDC2 plays a crucial role in modulating macrophage function and is associated with both colitis and colon tumorigenesis.
High CUEDC2 sensitizes chronic myeloid leukemic cells to imatinib treatment.
In response to UV irradiation, CUEDC2 undergoes ERK1/2 (show MAPK1/3 ELISA Kits)-dependent phosphorylation and ubiquitin-dependent degradation, leading to APC (show APC ELISA Kits)/C(Cdh1 (show CDH1 ELISA Kits))-mediated cyclin A (show CCNA2 ELISA Kits) destruction, cyclin-dependent kinase 2 (show KKIAMRE ELISA Kits) inactivation, and G1 arrest.
a new biological activity for CUEDC2 as the regulator of JAK1 (show JAK1 ELISA Kits)/STAT3 (show STAT3 ELISA Kits) signaling and the mechanism by which SOCS3 (show SOCS3 ELISA Kits) has been linked to suppression of the JAK (show JAK3 ELISA Kits)/STAT (show STAT1 ELISA Kits) pathway
CUEDC2 is a cell-cycle regulator that promotes spindle checkpoint inactivation and releases APC (show APC ELISA Kits)/C from checkpoint inhibition. CUEDC2 is phosphorylated by Cdk1 (show CDK1 ELISA Kits) during mitosis.
These results identify a key post-translational mechanism that controls progesterone receptor (show PGR ELISA Kits) protein levels and for the first time provide an important insight into the function of CUEDC2 in breast cancer proliferation.
Notably, CUEDC2 promoted E3 ubiquitin ligases tripartite motif-containing 33 (TRIM33 (show TRIM33 ELISA Kits))-mediated the antioxidant enzyme, glutathione peroxidase 1 (GPX1 (show GPX1 ELISA Kits)) ubiquitination, and proteasome-dependent degradation.
These findings demonstrate that CUEDC2 plays an important role in protection from colonic inflammation, primarily by inhibiting the NF-kappaB (show NFKB1 ELISA Kits) and STAT3 (show STAT3 ELISA Kits) signaling pathways and preventing excessive proliferation of the inflammatory epithelial cell.
Controls PGR and ESR1 protein levels through their targeting for ubiquitination and subsequent proteasomal degradation (By similarity).
CUE domain-containing protein 2-A
, mitotic phosphoprotein 38
, CUE domain containing 2
, CUE domain-containing protein 2-B
, CUE domain-containing protein 2