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Members of the CELF/BRUNOL protein family contain two N-terminal RNA recognition motif (RRM) domains, one C-terminal RRM domain, and a divergent segment of 160-230 aa between the second and third RRM domains. Additionally we are shipping CELF1 Kits (20) and CELF1 Proteins (9) and many more products for this protein.
Showing 10 out of 82 products:
Cow (Bovine) Monoclonal CELF1 Primary Antibody for FACS, GS - ABIN152357
Kress, Gautier-Courteille, Osborne, Babinet, Paillard: Inactivation of CUG-BP1/CELF1 causes growth, viability, and spermatogenesis defects in mice. in Molecular and cellular biology 2007
Show all 11 references for ABIN152357
Human Polyclonal CELF1 Primary Antibody for IHC (p), WB - ABIN657957
Le Tonquèze, Gschloessl, Namanda-Vanderbeken, Legagneux, Paillard, Audic: Chromosome wide analysis of CUGBP1 binding sites identifies the tetraspanin CD9 mRNA as a target for CUGBP1-mediated down-regulation. in Biochemical and biophysical research communications 2010
Show all 3 references for ABIN657957
CUG-BP1 affected the calcium release activity in single myofibers and the extent of atrophy was significantly reduced upon gene silencing of CUG-BP1 in atrophic muscle.
these data provided a comprehensive view of the CELF1 mRNA regulatory network in oral cancer
forced expression of miR (show MLXIP Antibodies)-214-3p enhances the sensitivity of esophageal cancer cells to cisplatin-induced apoptosis. This effect is abrogated with rescue expression of survivin (show BIRC5 Antibodies) or CUG-BP1
Expression of several genes within the CELF1 locus, including MTCH2 (show MTCH2 Antibodies), were highly correlated with one another and were associated with Alzheimer's disease status.
CUGBP1 and HuR (show ELAVL1 Antibodies) negate each other's effects in regulating E-cadherin (show CDH1 Antibodies) translation by altering the recruitment of E-cadherin (show CDH1 Antibodies) mRNA to PBs (show TSPO Antibodies) and play important roles in the regulation of intestinal barrier integrity.
CUGBP1 promotes cell proliferation and suppresses apoptosis via down-regulating C-EBPalpha (show CEBPA Antibodies) in human non-small cell lung cancers.
The results indicate that the cellular level of miR (show MLXIP Antibodies)-122 is determined by the balance between the opposing effects of GLD-2 (show PAPD4 Antibodies) and PARN (show PARN Antibodies)/CUGBP1 on the metabolism of its 3'-terminus.
CELF1 dysfunction in malignant T cells led to the up-regulation of a subset of GRE-containing transcripts that promote cell growth and down-regulation of another subset that suppress cell growth
Celf1 has a role in vegetal RNA localization during Xenopus oogenesis
These results demonstrate the importance of CUGBP1 in the biological and pathological functions of NSCLC and indicate its potential as a therapeutic target for NSCLC.
CELF1 downregulates Cyp19a1 (Aromatase (show CYP19A1 Antibodies)) posttranscriptionally to achieve high concentrations of testosterone compatible with spermiogenesis completion.
developmental stage-specific compatibility of CELF (show CEBPD Antibodies)-dependent splice variants dictates their effects on cardiac health and function
Differential expression of CELF1 in development plays a role in alternative splicing of vesicular trafficking genes in postnatal heart development.
Celf1 plays a distinctive and negative role in terminal myocyte differentiation, which partially contribute to DM1 RNA toxicity.
These results indicate that JNK2 (show MAPK9 Antibodies) is essential for maintenance of normal intestinal epithelial homeostasis and maturation under biological conditions by differentially modulating HuR (show ELAVL1 Antibodies) and CUGBP1.
CELF1 and CELF2 (show CELF2 Antibodies) may underlie conserved, developmentally regulated, tissue-specific processes in vertebrate embryos
Mitochondrial biogenesis occurs in the presence of increased CUG-BP1 and AUF1 (show HNRNPD Antibodies), suggesting that reductions in known mRNA destabilizing proteins likely does not contribute to exercise-induced mitochondrial biogenesis.
these results strongly support a role for -mediated alternative splicing in the regulation of contractile gene expression, achieved in part through modulating the activity of SRF, a key cardiac transcription factor.
This review is focused on the role of a conserved, multifunctional RNA-binding protein, CUGBP1, in the development of aging phenotype in the liver.
disruption of Celf1 gene is also responsible for a fully penetrant delayed first wave of spermatogenesis, and a delay of steroidogenesis may be the cause for the delay of germ cells differentiation
Results therefore suggest that Celf1 regulates proper organogenesis of endoderm-derived tissues by regulating the expression of such targets.
Celf1-dependent fine-tuning of dmrt2a (show DMRT2 Antibodies) expression is essential for generating bilateral symmetry of somites and left-right asymmetric patterning during zebrafish development.
not only mRNA but also protein of brul is localized to the zebrafish germ plasm at the ends of the cleavage furrows
This "target protector and rescue assay" demonstrates that the phenotypic defects associated with CUGBP1 inactivation in Xenopus are essentially due to the deregulation of Su(H (show RBPJ Antibodies)) mRNA.
Members of the CELF/BRUNOL protein family contain two N-terminal RNA recognition motif (RRM) domains, one C-terminal RRM domain, and a divergent segment of 160-230 aa between the second and third RRM domains. Members of this protein family regulate pre-mRNA alternative splicing and may also be involved in mRNA editing, and translation. This gene may play a role in myotonic dystrophy type 1 (DM1) via interactions with the dystrophia myotonica-protein kinase (DMPK) gene. Alternative splicing results in multiple transcript variants encoding different isoforms.
CUG triplet repeat, RNA binding protein 1
, CUGBP Elav-like family member 1
, 50 kDa nuclear polyadenylated RNA-binding protein
, CUG RNA-binding protein
, CUG triplet repeat RNA-binding protein 1
, CUG triplet repeat, RNA-binding protein 1
, CUG-BP- and ETR-3-like factor 1
, EDEN-BP homolog
, RNA-binding protein BRUNOL-2
, bruno-like 2
, bruno-like protein 2
, deadenylation factor CUG-BP
, embryo deadenylation element binding protein
, embryo deadenylation element-binding protein homolog
, nuclear polyadenylated RNA-binding protein, 50-kD
, brain protein F41
, deadenylation factor EDEN-BP
, EDEN-BP/Bruno-like protein
, CUG triplet repeat RNA-binding protein 1-A
, CUG-BP- and ETR-3-like factor 1-A
, CUGBP Elav-like family member 1-A
, RNA-binding protein BRUNOL-2-A
, bruno-like protein 2-A
, embryo deadenylation element-binding protein A