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negatively regulates Wnt signaling by binding to the PDZ domain. Additionally we are shipping CXXC Finger Protein 4 Proteins (6) and many more products for this protein.
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Human Polyclonal CXXC4 Primary Antibody for EIA, FACS - ABIN951745
Kojima, Shimazui, Hinotsu, Joraku, Oikawa, Kawai, Horie, Suzuki, Nagashima, Yoshikawa, Michiue, Asashima, Akaza, Uchida: Decreased expression of CXXC4 promotes a malignant phenotype in renal cell carcinoma by activating Wnt signaling. in Oncogene 2009
Show all 2 references for ABIN951745
Human Polyclonal CXXC4 Primary Antibody for EIA, WB - ABIN783773
Hino, Kishida, Michiue, Fukui, Sakamoto, Takada, Asashima, Kikuchi: Inhibition of the Wnt signaling pathway by Idax, a novel Dvl-binding protein. in Molecular and cellular biology 2001
IDAX depletion prevents TET2 downr (show CASP3 Antibodies)egulation in differe (show TET2 Antibodies)ntiating mouse embryonic stem cells
Age of patients and levels of CXXC4 mRNA, hemoglobin, and marrow blast associated with survival of Myelodysplastic syndrome patients.
EZH2 (show EZH2 Antibodies) can activate MAPK (show MAPK1 Antibodies) signaling by inhibiting CXXC4 expression.
CXXC4 is a novel potential tumor suppressor directly regulated by EZH2 (show EZH2 Antibodies), and its expression is a significant prognosis factor for patients with early stages of gastric cancer.
IDAX expression results in caspase (show CASP3 Antibodies) activation and TET2 (show TET2 Antibodies) protein downregulation, in a manner that depends on DNA binding through the IDAX CXXC domain, suggesting that IDAX recruits TET2 (show TET2 Antibodies) to DNA before degradation
Decreased CXXC4 was associated with kidney cancer metastasis, poor survival, beta-catenin (show CTNNB1 Antibodies) translocation, cell proliferation, reduced apoptosis in response to cancer drugs, and upregulation of genes involed in proliferation, invasion, and cell survival.
Idax functions are dependent on the canonical Wnt (show WNT2 Antibodies) pathway and are crucial for the anterior neural development
negatively regulates Wnt signaling by binding to the PDZ domain
CXXC-type zinc finger protein 4
, inhibition of the Dvl and axin complex protein
, CXXC finger 4
, Dvl-binding protein IDAX (inhibition of the Dvl and Axin complex)
, inhibitor of the Dvl and Axin complex